Literature DB >> 26064789

The COP9 signalosome and cullin-RING ligases in the heart.

Xuejun Wang1, Douglas S Martin1.   

Abstract

Alteration of ubiquitin-proteasome system (UPS) mediated protein degradation has been implicated in the progression from a large subset of heart disease to congestive heart failure, rendering it extremely important to elucidate the cellular and molecular mechanism by which the UPS is regulated. Cullin-RING ligases (CRLs) represent the largest family of ubiquitin ligases crucial for UPS-dependent proteolysis. Serving as a cullin deneddylase, the COP9 signalosome (CSN) regulates the activity and assembly of CRLs. In the past several years, emerging studies have begun to unveil the role of the CSN and some of the CRLs in cardiomyocytes or the heart under physiological and pathological conditions. This review article will highlight and analyze these recent progresses and provide the author's perspective on the future directions for this research field.

Entities:  

Keywords:  F-box proteins; The COP9 signalosome; autophagy; cullin-RING ligases; proteasome; ubiquitination

Year:  2015        PMID： 26064789      PMCID： PMC4447073     

Source DB:  PubMed          Journal:  Am J Cardiovasc Dis        ISSN： 2160-200X


  99 in total

1.  Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response.

Authors:  C Schwechheimer; G Serino; J Callis; W L Crosby; S Lyapina; R J Deshaies; W M Gray; M Estelle; X W Deng
Journal:  Science       Date:  2001-05-03       Impact factor: 47.728

Review 2.  Moonlighting and pleiotropy within two regulators of the degradation machinery: the proteasome lid and the CSN.

Authors:  Elah Pick; Laylan Bramasole
Journal:  Biochem Soc Trans       Date:  2014-12       Impact factor: 5.407

3.  The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2.

Authors:  T Kamura; M N Conrad; Q Yan; R C Conaway; J W Conaway
Journal:  Genes Dev       Date:  1999-11-15       Impact factor: 11.361

Review 4.  The COP9 signalosome.

Authors:  Ning Wei; Xing Wang Deng
Journal:  Annu Rev Cell Dev Biol       Date:  2003       Impact factor: 13.827

5.  Expression of a transgene encoding mutant p193/CUL7 preserves cardiac function and limits infarct expansion after myocardial infarction.

Authors:  R J Hassink; H Nakajima; H O Nakajima; P A Doevendans; L J Field
Journal:  Heart       Date:  2009-05-11       Impact factor: 5.994

6.  An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer.

Authors:  Teresa A Soucy; Peter G Smith; Michael A Milhollen; Allison J Berger; James M Gavin; Sharmila Adhikari; James E Brownell; Kristine E Burke; David P Cardin; Stephen Critchley; Courtney A Cullis; Amanda Doucette; James J Garnsey; Jeffrey L Gaulin; Rachel E Gershman; Anna R Lublinsky; Alice McDonald; Hirotake Mizutani; Usha Narayanan; Edward J Olhava; Stephane Peluso; Mansoureh Rezaei; Michael D Sintchak; Tina Talreja; Michael P Thomas; Tary Traore; Stepan Vyskocil; Gabriel S Weatherhead; Jie Yu; Julie Zhang; Lawrence R Dick; Christopher F Claiborne; Mark Rolfe; Joseph B Bolen; Steven P Langston
Journal:  Nature       Date:  2009-04-09       Impact factor: 49.962

7.  Role of the Arabidopsis RING-H2 protein RBX1 in RUB modification and SCF function.

Authors:  William M Gray; Hanjo Hellmann; Sunethra Dharmasiri; Mark Estelle
Journal:  Plant Cell       Date:  2002-09       Impact factor: 11.277

Review 8.  MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy.

Authors:  Steffan T Nawrocki; Patrick Griffin; Kevin R Kelly; Jennifer S Carew
Journal:  Expert Opin Investig Drugs       Date:  2012-07-16       Impact factor: 6.206

9.  Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface.

Authors:  David M Duda; Jennifer L Olszewski; Adriana E Tron; Michal Hammel; Lester J Lambert; M Brett Waddell; Tanja Mittag; James A DeCaprio; Brenda A Schulman
Journal:  Mol Cell       Date:  2012-06-28       Impact factor: 17.970

10.  Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins.

Authors:  Hui-Hua Li; Monte S Willis; Pamela Lockyer; Nathaniel Miller; Holly McDonough; David J Glass; Cam Patterson
Journal:  J Clin Invest       Date:  2007-11       Impact factor: 14.808
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  8 in total

Review 1.  The COP9 signalosome and vascular function: intriguing possibilities?

Authors:  Douglas S Martin; Xuejun Wang
Journal:  Am J Cardiovasc Dis       Date:  2015-03-20

2.  COP9 signalosome controls the degradation of cytosolic misfolded proteins and protects against cardiac proteotoxicity.

Authors:  Huabo Su; Jie Li; Hanming Zhang; Wenxia Ma; Ning Wei; Jinbao Liu; Xuejun Wang
Journal:  Circ Res       Date:  2015-09-17       Impact factor: 17.367

3.  Breaking down the COP9 Signalsome in the heart: how inactivating a protein ubiquitin ligase increases protein ubiquitylation and protects the heart.

Authors:  Christopher C Glembotski
Journal:  Circ Res       Date:  2015-11-06       Impact factor: 17.367

4.  Renal COP9 Signalosome Deficiency Alters CUL3-KLHL3-WNK Signaling Pathway.

Authors:  Ryan J Cornelius; Jinge Si; Catherina A Cuevas; Jonathan W Nelson; Brittany D K Gratreak; Ruggero Pardi; Chao-Ling Yang; David H Ellison
Journal:  J Am Soc Nephrol       Date:  2018-10-09       Impact factor: 10.121

5.  Mapping Keratoconus Molecular Substrates by Multiplexed High-Resolution Proteomics of Unpooled Corneas.

Authors:  Vishal Shinde; Nan Hu; Santosh Renuse; Alka Mahale; Akhilesh Pandey; Charles Eberhart; Donald Stone; Samar A Al-Swailem; Azza Maktabi; Shukti Chakravarti
Journal:  OMICS       Date:  2019-10-25

Review 6.  Role of the COP9 Signalosome (CSN) in Cardiovascular Diseases.

Authors:  Jelena Milic; Yuan Tian; Jürgen Bernhagen
Journal:  Biomolecules       Date:  2019-06-05

7.  Murine Myocardial Transcriptome Analysis Reveals a Critical Role of COPS8 in the Gene Expression of Cullin-RING Ligase Substrate Receptors and Redox and Vesicle Trafficking Pathways.

Authors:  Ammara Abdullah; Kathleen M Eyster; Travis Bjordahl; Peng Xiao; Erliang Zeng; Xuejun Wang
Journal:  Front Physiol       Date:  2017-08-17       Impact factor: 4.566

Review 8.  Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases.

Authors:  Stephanie Diaz; Kankan Wang; Benita Sjögren; Xing Liu
Journal:  Biomolecules       Date:  2022-03-08
  8 in total

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