Literature DB >> 2606475

Increased detectability of somatic changes in the DNA from human tumours after probing with "synthetic" and "genome-derived" hypervariable multilocus probes.

P J Lagoda1, G Seitz, J T Epplen, O G Issinger.   

Abstract

DNA fingerprinting with two minisatellite (33.15, M13) and two simple repeat probes [(GACA)4, (CAC)5/(GTG)s] was performed to screen for somatic changes in the DNA from various solid human tumours in comparison with constitutional DNA from the same patient. Loss of bands or changes in band intensities were observed. Together the probes 33.15 and (CAC)5/(GTG)5 detected deviating fingerprint patterns in 63% of the colorectal carcinomas investigated. In mammary and stomach carcinomas, only 1/11 and 2/11 tumours, respectively, showed differences with either of the three probes, 33.15, (GACA)4 and (CAC)5/(GTG)5.

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Year:  1989        PMID： 2606475     DOI： 10.1007/bf00210667

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  34 in total

1.  Fingerprinting cell lines: use of human hypervariable DNA probes to characterize mammalian cell cultures.

Authors:  J Thacker; M B Webb; P G Debenham
Journal:  Somat Cell Mol Genet       Date:  1988-11

2.  Localization of the genetic defect in familial adenomatous polyposis within a small region of chromosome 5.

Authors:  Y Nakamura; M Lathrop; M Leppert; M Dobbs; J Wasmuth; E Wolff; M Carlson; E Fujimoto; K Krapcho; T Sears
Journal:  Am J Hum Genet       Date:  1988-11       Impact factor: 11.025

3.  Individual-specific 'fingerprints' of human DNA.

Authors:  A J Jeffreys; V Wilson; S L Thein
Journal:  Nature       Date:  1985 Jul 4-10       Impact factor: 49.962

4.  Clustering of hypervariable minisatellites in the proterminal regions of human autosomes.

Authors:  N J Royle; R E Clarkson; Z Wong; A J Jeffreys
Journal:  Genomics       Date:  1988-11       Impact factor: 5.736

5.  DNA fingerprinting and 'scientific' whaling.

Authors:  A R Hoelzel; W Amos
Journal:  Nature       Date:  1988-05-26       Impact factor: 49.962

6.  Hypervariable 'minisatellite' regions in human DNA.

Authors:  A J Jeffreys; V Wilson; S L Thein
Journal:  Nature       Date:  1985 Mar 7-13       Impact factor: 49.962

7.  Differences in DNA-fingerprints between remission and relapse in childhood acute lymphoblastic leukemia.

Authors:  S Pakkala; P Helminen; U M Saarinen; R Alitalo; L Peltonen
Journal:  Leuk Res       Date:  1988       Impact factor: 3.156

Review 8.  Gene amplification in cultured animal cells.

Authors:  R T Schimke
Journal:  Cell       Date:  1984-07       Impact factor: 41.582

9.  DNA finger printing by oligonucleotide probes specific for simple repeats.

Authors:  S Ali; C R Müller; J T Epplen
Journal:  Hum Genet       Date:  1986-11       Impact factor: 4.132

10.  Somatic changes in B-lymphoproliferative disorders (B-LPD) detected by DNA-fingerprinting.

Authors:  D de Jong; B M Voetdijk; J C Kluin-Nelemans; G J van Ommen; P M Kluin
Journal:  Br J Cancer       Date:  1988-12       Impact factor: 7.640
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  6 in total

1.  Non-radioactive in situ hybridization pattern of the M13 minisatellite sequences on human metaphase chromosomes.

Authors:  A Christmann; P J Lagoda; K D Zang
Journal:  Hum Genet       Date:  1991-03       Impact factor: 4.132

2.  Hypervariable individual-specific DNA band patterns revealed by a 22mer promoter-specific oligonucleotide probe containing an SP1 site.

Authors:  A Menzel; P J Lagoda; O G Issinger
Journal:  Nucleic Acids Res       Date:  1990-07-25       Impact factor: 16.971

3.  DNA fingerprint analysis for the detection of induced mutations in mammalian cells in culture.

Authors:  P Vagnarelli; E Raimondi; C Coelli; P Fattorini; E Dorigo; L De Carli
Journal:  Cytotechnology       Date:  1995-06       Impact factor: 2.058

4.  DNA fingerprinting with the oligonucleotide probe (CAC)5/(GTG)5: somatic stability and germline mutations.

Authors:  P Nürnberg; L Roewer; H Neitzel; K Sperling; A Pöpperl; J Hundrieser; H Pöche; C Epplen; H Zischler; J T Epplen
Journal:  Hum Genet       Date:  1989-12       Impact factor: 4.132

5.  Detection by DNA fingerprinting of somatic changes during the establishment of a new prostate cell line.

Authors:  P D van Helden; I J Wiid; E G Hoal-van Helden; E Bey; R Cohen
Journal:  Br J Cancer       Date:  1994-08       Impact factor: 7.640

6.  Frequent and multiple mutations at minisatellite loci in sporadic human colorectal and gastric cancers--possible mechanistic differences from microsatellite instability in cancer cells.

Authors:  Hideaki Inamori; Sachiyo Takagi; Rie Tajima; Masako Ochiai; Tsuneyuki Ubagai; Takashi Sugimura; Minako Nagao; Hitoshi Nakagama
Journal:  Jpn J Cancer Res       Date:  2002-04
  6 in total

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