Shaoyan Zhang1, Weihua Jiang2, Xiuming Tang3, Quanchen Xu4, Jingli Wang5, Rui Gui6, Xinhua Zhang2, Shiguo Liu7. 1. Clinical Laboratory, The Affiliated Hospital of Qingdao University Qingdao 266003, China. 2. Department of Psychiatry, Medical College, Qingdao University Qingdao, 266021, China. 3. Reproductive Medicine Centre, The Affiliated Hospital of Qingdao University Qingdao 266003, China. 4. The Affiliated Hospital of Qingdao University Qingdao 266003, China. 5. Prenatal Diagnosis Center, The Affiliated Hospital of Qingdao University Qingdao, 266003, China. 6. Clinical Laboratory, Pingyi Hospital Chinese Medicine Shandong, China. 7. Prenatal Diagnosis Center, The Affiliated Hospital of Qingdao University Qingdao, 266003, China ; Genetic Laboratory, The Affiliated Hospital of Qingdao University Qingdao 266003, China.
Abstract
OBJECTIVE: Multiple evidence suggests an involvement of the dopamine neurotransmitter system in Obsessive-compulsive disorder (OCD). Therefore, we explore the association of 3'UTR region of 40 bp variable tandem repeat (VNTR) polymorphism in Dopamine Transporter Gene (DAT1) in Chinese Han population. METHODS: A total of 305 OCD patients and 435 healthy individuals were recruited for the study. OCD was diagnosed with the Forth Edition (DSM-IV) diagnostic criteria. After polymerase chain reaction of VNTR was used to evaluate the 40 bp VNTR polymorphism in DAT1, a case-control association analysis was performed by the χ(2) test. RESULTS: The results showed that no association was found between OCD patients and controls for the genotype distribution (X(2) =0.743, P=0.690, df=2) as well as allelic (X(2)=0.172, P=0.678, OR=0.928, 95% Cl=0.885-1.224) distribution. CONCLUSIONS: Our data suggest that the 40 bp VNTR polymorphism in DAT1 may not be associated with susceptibility to OCD in the Chinese Han population studied. However, this result needed to be replicated from different populations.
OBJECTIVE: Multiple evidence suggests an involvement of the dopamine neurotransmitter system in Obsessive-compulsive disorder (OCD). Therefore, we explore the association of 3'UTR region of 40 bp variable tandem repeat (VNTR) polymorphism in Dopamine Transporter Gene (DAT1) in Chinese Han population. METHODS: A total of 305 OCDpatients and 435 healthy individuals were recruited for the study. OCD was diagnosed with the Forth Edition (DSM-IV) diagnostic criteria. After polymerase chain reaction of VNTR was used to evaluate the 40 bp VNTR polymorphism in DAT1, a case-control association analysis was performed by the χ(2) test. RESULTS: The results showed that no association was found between OCDpatients and controls for the genotype distribution (X(2) =0.743, P=0.690, df=2) as well as allelic (X(2)=0.172, P=0.678, OR=0.928, 95% Cl=0.885-1.224) distribution. CONCLUSIONS: Our data suggest that the 40 bp VNTR polymorphism in DAT1 may not be associated with susceptibility to OCD in the Chinese Han population studied. However, this result needed to be replicated from different populations.
Entities:
Keywords:
40 bp VNTR; DAT1; OCD; association analysis; susceptibility
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