Atilla Karateke1, Dilek Benk Silfeler2, Arif Güngören2, Raziye Keskin Kurt2, Ayşe Güler Okyay2, Recep Dokuyucu3, Turker Ulutas4, Burak Un5, Hacer Paksoy6, Ali Ulvi Hakverdi2. 1. Antakya State Hospital, Obstetrics and Gynecology Clinic Hatay, Turkey. 2. Department of Obstetrics and Gynecology, Mustafa Kemal University, Faculty of Medicine Hatay, Turkey. 3. Department of Medical Physiology, Medical Faculty, Mustafa Kemal University Hatay, Turkey. 4. Kadirli State Hospital, Biochemistry Clinic Osmaniye, Turkey. 5. Kadirli State Hospital, Obstetrics and Gynecology Clinic Osmaniye, Turkey. 6. Department of Physical Medicine and Rehabilitation, Mustafa Kemal University, Faculty of Medicine Hatay, Turkey.
Abstract
OBJECTIVE: The aim of our study was to investigate the ductus venosus doppler between 11-13+6 (week-day) in pregnant women with hemoglobinopaties and its relation with fetal outcomes. MATERIAL AND METHODS: A total of 100 pregnant women with hemoglobinopathies and 100 healthy pregnant women were included in our study. Ultrasonography (USG) was performed to all pregnant women and the ductus venosus doppler (DVD) flows were evaluated. The results were statistically analyzed. RESULTS: The mean hemoglobin level was significantly lower in hemoglobinopathy group (9.7 ± 0.7) than control group (10.67 ± 0.82) (P<0.001). There was a significant relationship between Vmax, Vmin, S/D and reverse 'a' wave in fetuses with hemoglobinopathies. Vmax, Vmin and S/D parameters were higher in the group of hemoglobinopathies (respectively mean value, 31.3 ± 1.66, 8.90 ± 0.81, 2.97 ± 0.49). Reverse 'a' wave was detected especially in all fetuses with sickle cell anemia. There was no significantly relationship between the groups in terms of PI, RI and HR. In a logistic regression analyses, fetal hemoglobinopathy was independently associated with Vmin (β = 1.07, P = 0.001), S/D (β = 2.61, P = 0.001) and reverse 'a' wave (β = 2.46, P = 0.004). CONCLUSION: Pregnant women with hemoglobinopathies had changed ductus venosus doppler values in compared to normal pregnant women. Maternal anemia may cause this doppler changes. Furthermore all fetuses with sickle cell anemia (n = 5) had abnormal ductus venosus doppler findings. Further studies are needed to investigate the relationship between abnormal ductus venosus doppler findings and fetuses diagnosed with sickle cell anemia.
OBJECTIVE: The aim of our study was to investigate the ductus venosus doppler between 11-13+6 (week-day) in pregnant women with hemoglobinopaties and its relation with fetal outcomes. MATERIAL AND METHODS: A total of 100 pregnant women with hemoglobinopathies and 100 healthy pregnant women were included in our study. Ultrasonography (USG) was performed to all pregnant women and the ductus venosus doppler (DVD) flows were evaluated. The results were statistically analyzed. RESULTS: The mean hemoglobin level was significantly lower in hemoglobinopathy group (9.7 ± 0.7) than control group (10.67 ± 0.82) (P<0.001). There was a significant relationship between Vmax, Vmin, S/D and reverse 'a' wave in fetuses with hemoglobinopathies. Vmax, Vmin and S/D parameters were higher in the group of hemoglobinopathies (respectively mean value, 31.3 ± 1.66, 8.90 ± 0.81, 2.97 ± 0.49). Reverse 'a' wave was detected especially in all fetuses with sickle cell anemia. There was no significantly relationship between the groups in terms of PI, RI and HR. In a logistic regression analyses, fetal hemoglobinopathy was independently associated with Vmin (β = 1.07, P = 0.001), S/D (β = 2.61, P = 0.001) and reverse 'a' wave (β = 2.46, P = 0.004). CONCLUSION: Pregnant women with hemoglobinopathies had changed ductus venosus doppler values in compared to normal pregnant women. Maternal anemia may cause this doppler changes. Furthermore all fetuses with sickle cell anemia (n = 5) had abnormal ductus venosus doppler findings. Further studies are needed to investigate the relationship between abnormal ductus venosus doppler findings and fetuses diagnosed with sickle cell anemia.
Authors: A Matias; N Montenegro; T Loureiro; M Cunha; S Duarte; D Freitas; M Severo Journal: Ultrasound Obstet Gynecol Date: 2010-02 Impact factor: 7.299