Tao Liu1, Li Jiang2, Xiaoxing Lv2, Jinqing Li2, Yuejun Li2, Wangzhou Li2, Xueyong Li2, Jing Li2. 1. Department of Dermatology, Tangdu Hospital, Fourth Military Medical University 569 Xinsi Road, Xi'an 710038, China. 2. Department of Burns and Plastic Surgery, Tangdu Hospital, Fourth Military Medical University 569 Xinsi Road, Xi'an 710038, China.
Abstract
BACKGROUND: Published studies have generated inconsistent results related to the contribution of CRR9 rs401681 C allele to the risk of developing non-melanoma skin cancer (NMSC), and it is the inconsistency that promoted us to undertake a meta-analysis to identify the degree of impact the C allele has on NMSC. METHOD: The PubMed, Science Direct, Embase and Cochrane Library were thoroughly searched from the start of November 2013 to the end of April 2014 by using CRR9, polymorphism, skin cancer and their synonyms. Based on a total of 44,036 subjects, we calculated ORs and 95% CIs to measure the influence of the C allele on NMSC predisposition. RESULTS: Overall, individuals carrying the risk C allele at rs401681 had 1.16 times (OR = 1.16, 95% CI: 1.10-1.21, heterogeneity: P = 0.298 and I2 = 0.166, Figure 2) greater risk of NMSC compared to the common T allele. In the further stratified analyses, we found a significant association between the C allele and BCC, Icelanders, and non-Icelanders. CONCLUSION: The results of this meta-analysis suggest that the C allele at rs401681 is likely to modify the genetic predisposition to NMSC.
BACKGROUND: Published studies have generated inconsistent results related to the contribution of CRR9rs401681 C allele to the risk of developing non-melanoma skin cancer (NMSC), and it is the inconsistency that promoted us to undertake a meta-analysis to identify the degree of impact the C allele has on NMSC. METHOD: The PubMed, Science Direct, Embase and Cochrane Library were thoroughly searched from the start of November 2013 to the end of April 2014 by using CRR9, polymorphism, skin cancer and their synonyms. Based on a total of 44,036 subjects, we calculated ORs and 95% CIs to measure the influence of the C allele on NMSC predisposition. RESULTS: Overall, individuals carrying the risk C allele at rs401681 had 1.16 times (OR = 1.16, 95% CI: 1.10-1.21, heterogeneity: P = 0.298 and I2 = 0.166, Figure 2) greater risk of NMSC compared to the common T allele. In the further stratified analyses, we found a significant association between the C allele and BCC, Icelanders, and non-Icelanders. CONCLUSION: The results of this meta-analysis suggest that the C allele at rs401681 is likely to modify the genetic predisposition to NMSC.
Entities:
Keywords:
CRR9; Genetic risk; non-melanoma skin cancer
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