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Literature DB >> 26064211

Resveratrol alleviates nerve injury after cerebral ischemia and reperfusion in mice by inhibiting inflammation and apoptosis.

Liqun Fang¹, Hongmei Gao¹, Weina Zhang¹, Wenjie Zhang¹, Yanan Wang¹.

Abstract

The role of resveratrol in cerebral ischemia/reperfusion injury is not well understood. The aim of this study was to investigate whether resveratrol modulates inflammation and oxidative stress in cerebral ischemia/reperfusion injury in mice. Rats were subjected to 2 h of transient middle cerebral artery occlusion (MCAO), followed by 24 h of reperfusion. Rats were randomly exposed to sham operation group, MCAO group and MCAO+ resveratrol group. The results demonstrated that compared to I/R, resveratrol reduced cerebral infarction area, brain water content, neuronal apoptosis, myeloperoxidase (MPO) levels, and cerebral TNF-α production. Our results suggested that resveratrol has protective effects against cerebral I/R injury in rats, which may be attributed to attenuating inflammation and apoptosis induced by cerebral ischemia reperfusion.

Entities: Chemical Disease Gene Species

Keywords: Resveratrol; TNF-α; apoptosis; cerebral ischemia; inflammation; stroke

Year: 2015 PMID： 26064211 PMCID： PMC4443045

Source DB: PubMed Journal: Int J Clin Exp Med ISSN： 1940-5901

26 in total

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Review 2. Therapeutic strategies for the treatment of stroke.

Authors: A Richard Green; Ashfaq Shuaib
Journal: Drug Discov Today Date: 2006-08 Impact factor: 7.851

3. State and metropolitan-area estimates of disability in the United States, 2001.

Authors: Catherine A Okoro; Lina S Balluz; Vincent A Campbell; James B Holt; Ali H Mokdad
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Review 5. Reactive oxygen radicals in signaling and damage in the ischemic brain.

Authors: P H Chan
Journal: J Cereb Blood Flow Metab Date: 2001-01 Impact factor: 6.200

Review 6. The cost of cerebral ischaemia.

Authors: R W V Flynn; R S M MacWalter; A S F Doney
Journal: Neuropharmacology Date: 2008-06-05 Impact factor: 5.250

Review 7. Impact of oxidative stress on neuronal survival.

Authors: Juliet M Taylor; Peter J Crack
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8. Reversible middle cerebral artery occlusion without craniectomy in rats.

Authors: E Z Longa; P R Weinstein; S Carlson; R Cummins
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Review 9. Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia.

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