Comparative antiulcer and antisecretory effects of various calcium antagonists.

1. The antiulcer activity (ethanol or indomethacin-induced ulcers) and the antisecretory effects (pylorus-ligated rats) of various selective and non selective calcium antagonists were studied. 2. Flunarizine and pirenzepine reduce the ethanol-ulcer length whereas diltiazem and cimetidine are weakly active and verapamil, nifedipine and nicardipine are ineffective. 3. All tested compounds except verapamil prevent the development of indomethacin-induced ulceration. 4. All substances, except flunarizine decrease the total H+ output in Shay rats. 5. The activities of the different compounds are discussed in terms of their mode of action.