Yan Li1, Lei Liu, Bin Wang, Dongfeng Chen, Jun Wang. 1. aDepartment of Gastroenterology, Institute of Surgery Research, Daping Hospital bDepartment of Natural Medicinal Chemistry, Biowave Center, College of Pharmacy, Third Military Medical University, Chongqing, China.
Abstract
OBJECTIVES: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the world. Some reports have shown that NAFLD may cause multisystem damage, but its influence on male reproductive function has rarely been studied. AIM: To evaluate the influence of NAFLD on sperm quality and reproductive hormones in Chinese men. MATERIALS AND METHODS: A total of 102 NAFLD men and 94 healthy men without fatty liver (control) were enrolled in this study. All participants underwent a physical examination, and were subjected to lifestyle questionnaires and abdominal ultrasound examination. The semen quality (volume, concentration, motility, and morphology) and serum hormonal levels (testosterone, estradiol, follicle-stimulating hormone, inhibin B, sex hormone-binding globulin, and luteinizing hormone) were examined and compared between the two groups. RESULTS: The levels of serum testosterone and sex hormone-binding globulin were significantly lower in the NAFLD patients compared with the control group. Sperm concentration (P=0.04), sperm count (P=0.01), and total motility (P=0.03) in the NAFLD patients were significantly decreased compared with the control group. However, no significant differences were observed in semen volume and morphology. Multivariate analysis showed that sperm concentration, sperm count, and motility were significantly associated with NAFLD and abstinence (P<0.05 or P<0.001). CONCLUSION: These results suggest that NAFLD could significantly affect sperm quality and reproductive hormones.
OBJECTIVES:Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the world. Some reports have shown that NAFLD may cause multisystem damage, but its influence on male reproductive function has rarely been studied. AIM: To evaluate the influence of NAFLD on sperm quality and reproductive hormones in Chinese men. MATERIALS AND METHODS: A total of 102 NAFLD men and 94 healthy men without fatty liver (control) were enrolled in this study. All participants underwent a physical examination, and were subjected to lifestyle questionnaires and abdominal ultrasound examination. The semen quality (volume, concentration, motility, and morphology) and serum hormonal levels (testosterone, estradiol, follicle-stimulating hormone, inhibin B, sex hormone-binding globulin, and luteinizing hormone) were examined and compared between the two groups. RESULTS: The levels of serum testosterone and sex hormone-binding globulin were significantly lower in the NAFLD patients compared with the control group. Sperm concentration (P=0.04), sperm count (P=0.01), and total motility (P=0.03) in the NAFLD patients were significantly decreased compared with the control group. However, no significant differences were observed in semen volume and morphology. Multivariate analysis showed that sperm concentration, sperm count, and motility were significantly associated with NAFLD and abstinence (P<0.05 or P<0.001). CONCLUSION: These results suggest that NAFLD could significantly affect sperm quality and reproductive hormones.
Authors: Frederique Van de Velde; Marlies Bekaert; Anne Hoorens; Anja Geerts; Guy T'Sjoen; Tom Fiers; Jean-Marc Kaufman; Yves Van Nieuwenhove; Bruno Lapauw Journal: Asian J Androl Date: 2020 May-Jun Impact factor: 3.285