Literature DB >> 2606094

Biotransformation of pteroylmonoglutamic acid during absorption: implications of Michaelis-Menten kinetics.

M Lucock1, J Wild, R Smithells, R Hartley.   

Abstract

Previously reported work from this laboratory has shown that, in man, the formation of plasma 5-methyltetrahydrofolic acid (5MeTHF) from orally administered pteroylmonoglutamic acid (PGA) obeys Michaelis-Menten kinetics. The regression equation obtained from a plot of the reciprocal amount of 5MeTHF formed (micrograms per litre plasma/min) as a function of reciprocal amount of PGA administered (micrograms/kg body weight) provides a useful means of calculating the improved efficiency of 5MeTHF formation by dividing the total dose of PGA into smaller doses.

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Year:  1989        PMID： 2606094

Source DB:  PubMed          Journal:  Eur J Clin Nutr        ISSN： 0954-3007            Impact factor:   4.016


  8 in total

1.  Plasma folate levels in preterm infants, with and without a 1 mg daily folate supplement.

Authors:  N J Fuller; C J Bates; T J Cole; A Lucas
Journal:  Eur J Pediatr       Date:  1992-01       Impact factor: 3.183

2.  Unmetabolized serum folic acid and its relation to folic acid intake from diet and supplements in a nationally representative sample of adults aged > or =60 y in the United States.

Authors:  Regan L Bailey; James L Mills; Elizabeth A Yetley; Jaime J Gahche; Christine M Pfeiffer; Johanna T Dwyer; Kevin W Dodd; Christopher T Sempos; Joseph M Betz; Mary Frances Picciano
Journal:  Am J Clin Nutr       Date:  2010-06-23       Impact factor: 7.045

Review 3.  Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics.

Authors:  Klaus Pietrzik; Lynn Bailey; Barry Shane
Journal:  Clin Pharmacokinet       Date:  2010-08       Impact factor: 6.447

4.  Folate, vitamin B12, vitamin B6 and homocysteine: impact on pregnancy outcome.

Authors:  Denise Furness; Michael Fenech; Gustaaf Dekker; T Yee Khong; Claire Roberts; William Hague
Journal:  Matern Child Nutr       Date:  2011-10-24       Impact factor: 3.092

5.  Circulating folic acid in plasma: relation to folic acid fortification.

Authors:  Renee D Kalmbach; Silvina F Choumenkovitch; Aron M Troen; Ralph D'Agostino; Paul F Jacques; Jacob Selhub
Journal:  Am J Clin Nutr       Date:  2008-09       Impact factor: 7.045

6.  Serum unmetabolized folic acid in a nationally representative sample of adults ≥60 years in the United States, 2001-2002.

Authors:  Regan L Bailey; James L Mills; Elizabeth A Yetley; Jaime J Gahche; Christine M Pfeiffer; Johanna T Dwyer; Kevin W Dodd; Christopher T Sempos; Joseph M Betz; Mary Frances Picciano
Journal:  Food Nutr Res       Date:  2012-04-02       Impact factor: 3.894

Review 7.  Safety and benefits of interventions to increase folate status in malaria-endemic areas.

Authors:  Hans Verhoef; Jacobien Veenemans; Martin N Mwangi; Andrew M Prentice
Journal:  Br J Haematol       Date:  2017-03-29       Impact factor: 6.998

8.  Randomized control trial evaluation of a modified Paleolithic dietary intervention in the treatment of relapsing-remitting multiple sclerosis: a pilot study.

Authors:  Amanda K Irish; Constance M Erickson; Terry L Wahls; Linda G Snetselaar; Warren G Darling
Journal:  Degener Neurol Neuromuscul Dis       Date:  2017-01-04
  8 in total

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