Jason L Rengo1, Damien M Callahan2,3, Patrick D Savage1, Philip A Ades1,2, Michael J Toth2,3. 1. Department of Cardiology, University of Vermont Medical Center, Burlington, Vermont, USA. 2. Department of Medicine, University of Vermont, College of Medicine, Burlington, Vermont, USA. 3. Department of Molecular Physiology and Biophysics, University of Vermont, College of Medicine, Burlington, Vermont, USA.
Abstract
INTRODUCTION: Statins have well-known benefits on cardiovascular mortality, though up to 15% of patients experience side effects. With guidelines from the American Heart Association, American College of Cardiology, and American Diabetes Association expected to double the number of statin users, the overall incidence of myalgia and myopathy will increase. METHODS: We evaluated skeletal muscle structure and contractile function at the molecular, cellular, and whole tissue levels in 12 statin tolerant and 12 control subjects. RESULTS: Myosin isoform expression, fiber type distributions, single fiber maximal Ca(2+) -activated tension, and whole muscle contractile force were similar between groups. No differences were observed in myosin-actin cross-bridge kinetics in myosin heavy chain I or IIA fibers. CONCLUSIONS: We found no evidence for statin-induced changes in muscle morphology at the molecular, cellular, or whole tissue levels. Collectively, our data show that chronic statin therapy in healthy asymptomatic individuals does not promote deleterious myofilament structural or functional adaptations.
INTRODUCTION: Statins have well-known benefits on cardiovascular mortality, though up to 15% of patients experience side effects. With guidelines from the American Heart Association, American College of Cardiology, and American Diabetes Association expected to double the number of statin users, the overall incidence of myalgia and myopathy will increase. METHODS: We evaluated skeletal muscle structure and contractile function at the molecular, cellular, and whole tissue levels in 12 statin tolerant and 12 control subjects. RESULTS:Myosin isoform expression, fiber type distributions, single fiber maximal Ca(2+) -activated tension, and whole muscle contractile force were similar between groups. No differences were observed in myosin-actin cross-bridge kinetics in myosin heavy chain I or IIA fibers. CONCLUSIONS: We found no evidence for statin-induced changes in muscle morphology at the molecular, cellular, or whole tissue levels. Collectively, our data show that chronic statin therapy in healthy asymptomatic individuals does not promote deleterious myofilament structural or functional adaptations.
Authors: Kathryn E Ferrier; Michael H Muhlmann; Jean Philippe Baguet; James D Cameron; Garry L Jennings; Anthony M Dart; Bronwyn A Kingwell Journal: J Am Coll Cardiol Date: 2002-03-20 Impact factor: 24.094
Authors: David J Graham; Judy A Staffa; Deborah Shatin; Susan E Andrade; Stephanie D Schech; Lois La Grenade; Jerry H Gurwitz; K Arnold Chan; Michael J Goodman; Richard Platt Journal: JAMA Date: 2004-11-22 Impact factor: 56.272
Authors: Catherine R Mikus; Leryn J Boyle; Sarah J Borengasser; Douglas J Oberlin; Scott P Naples; Justin Fletcher; Grace M Meers; Meghan Ruebel; M Harold Laughlin; Kevin C Dellsperger; Paul J Fadel; John P Thyfault Journal: J Am Coll Cardiol Date: 2013-04-10 Impact factor: 24.094
Authors: Mark S Miller; Damien M Callahan; Timothy W Tourville; James R Slauterbeck; Anna Kaplan; Brad R Fiske; Patrick D Savage; Philip A Ades; Bruce D Beynnon; Michael J Toth Journal: J Appl Physiol (1985) Date: 2017-01-12
Authors: Michael J Toth; Patrick D Savage; Thomas B Voigt; Bradley M Anair; Janice Y Bunn; Isaac B Smith; Timothy W Tourville; Michael Blankstein; Jennifer Stevens-Lapsley; Nathaniel J Nelms Journal: J Appl Physiol (1985) Date: 2022-07-28
Authors: Laurette van Boheemen; Susan E Tett; Evelien Sohl; Jacqueline G Hugtenburg; Natasja M van Schoor; G M E E Peeters Journal: Drugs Aging Date: 2016-06 Impact factor: 3.923
Authors: William M Southern; Anna S Nichenko; Daniel D Shill; Corey C Spencer; Nathan T Jenkins; Kevin K McCully; Jarrod A Call Journal: PLoS One Date: 2017-02-16 Impact factor: 3.240
Authors: Blas A Guigni; Damien M Callahan; Timothy W Tourville; Mark S Miller; Brad Fiske; Thomas Voigt; Bethany Korwin-Mihavics; Vikas Anathy; Kim Dittus; Michael J Toth Journal: Am J Physiol Cell Physiol Date: 2018-09-12 Impact factor: 4.249