Literature DB >> 2605686

A cytotoxic constituent of Lysimachia japonica THUNB. (Primulaceae) and the structure-activity relationships of related compounds.

M Arisawa, K Ohmura, A Kobayashi, N Morita.   

Abstract

A cytotoxic alkylresorcinol was isolated from Lysimachia japonica THUNB. (Primulaceae) and identified as grevillol (2). It was tested for cytotoxicity against KB, B-16, PC-13, L-5178Y, P-388, and HEp-2 cells in vitro. Synthetic related compounds were also tested for cytotoxicity against the KB cell line, and the structure-activity relationships are discussed.

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Year:  1989        PMID： 2605686     DOI： 10.1248/cpb.37.2431

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  6 in total

Review 1.  Biological activity of phenolic lipids.

Authors:  Maria Stasiuk; A Kozubek
Journal:  Cell Mol Life Sci       Date:  2010-03       Impact factor: 9.261

2.  Potential Anticancer Agents Characterized from Selected Tropical Plants.

Authors:  Yulin Ren; Esperanza J Carcache de Blanco; James R Fuchs; Djaja D Soejarto; Joanna E Burdette; Steven M Swanson; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2019-03-04       Impact factor: 4.050

3.  Induction of apoptosis on human hepatocarcinoma cell lines by an alkyl resorcinol isolated from Lithraea molleoides.

Authors:  Luciana Barbini; Paula Lopez; Julieta Ruffa; Virginia Martino; Graciela Ferraro; Rodolfo Campos; Lucia Cavallaro
Journal:  World J Gastroenterol       Date:  2006-10-07       Impact factor: 5.742

Review 4.  Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades.

Authors:  Cheng-Shi Jiang; Lin-fu Liang; Yue-wei Guo
Journal:  Acta Pharmacol Sin       Date:  2012-09-03       Impact factor: 6.150

5.  A Hydroquinone-Based Derivative Elicits Apoptosis and Autophagy via Activating a ROS-Dependent Unfolded Protein Response in Human Glioblastoma.

Authors:  Silvia Zappavigna; Alessia Maria Cossu; Marianna Abate; Gabriella Misso; Angela Lombardi; Michele Caraglia; Rosanna Filosa
Journal:  Int J Mol Sci       Date:  2019-08-06       Impact factor: 5.923

6.  A novel cytosporone 3-Heptyl-4,6-dihydroxy-3H-isobenzofuran-1-one: synthesis; toxicological, apoptotic and immunomodulatory properties; and potentiation of mutagenic damage.

Authors:  Rodrigo Juliano Oliveira; Stephanie Dynczuki Navarro; Dênis Pires de Lima; Alisson Meza; João Renato Pesarini; Roberto da Silva Gomes; Caroline Bilhar Karaziack; Mariana de Oliveira Mauro; Andréa Luiza Cunha-Laura; Antônio Carlos Duenhas Monreal; Wanderson Romão; Valdemar Lacerda Júnior; Adilson Beatriz
Journal:  BMC Cancer       Date:  2015-07-31       Impact factor: 4.430
  6 in total

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