Literature DB >> 26056514

Assessing drug and metabolite detection in liver tissue by UV-MALDI and IR-MALDESI mass spectrometry imaging coupled to FT-ICR MS.

Jeremy A Barry1, M Reid Groseclose2, Guillaume Robichaud1, Stephen Castellino2, David C Muddiman1.   

Abstract

Determining the distribution of a drug and its metabolites within tissue is a key facet of evaluating drug candidates. Drug distribution can have a significant implication in appraising drug efficacy and potential toxicity. The specificity and sensitivity of mass spectrometry imaging (MSI) make it a perfect complement to the analysis of drug distributions in tissue. The detection of lapatinib as well as several of its metabolites in liver tissue was determined by MSI using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) coupled to high resolving power Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometers. IR-MALDESI required minimal sample preparation while maintaining high sensitivity. The effect of the electrospray solvent composition on IR-MALDESI MSI signal from tissue analysis was investigated and an empirical comparison of IR-MALDESI and UV-MALDI for MSI analysis is also presented.

Entities:  

Keywords:  IR-MALDESI; MALDI; drug distribution; mass spectrometry imaging

Year:  2015        PMID： 26056514      PMCID： PMC4456684          DOI： 10.1016/j.ijms.2014.05.012

Source DB:  PubMed          Journal:  Int J Mass Spectrom        ISSN： 1387-3806            Impact factor:   1.986


  52 in total

1.  Mass spectrometry imaging with high resolution in mass and space (HR(2) MSI) for reliable investigation of drug compound distributions on the cellular level.

Authors:  Andreas Römpp; Sabine Guenther; Zoltan Takats; Bernhard Spengler
Journal:  Anal Bioanal Chem       Date:  2011-04-26       Impact factor: 4.142

2.  Direct analysis of drug candidates in tissue by matrix-assisted laser desorption/ionization mass spectrometry.

Authors:  Michelle L Reyzer; Yunsheng Hsieh; Kwokei Ng; Walter A Korfmacher; Richard M Caprioli
Journal:  J Mass Spectrom       Date:  2003-10       Impact factor: 1.982

3.  Desorption electrospray ionization mass spectrometry: Imaging drugs and metabolites in tissues.

Authors:  Justin M Wiseman; Demian R Ifa; Yongxin Zhu; Candice B Kissinger; Nicholas E Manicke; Peter T Kissinger; R Graham Cooks
Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-12       Impact factor: 11.205

4.  Drug distribution. The forgotten relative in clinical pharmacokinetics.

Authors:  H G Eichler; M Müller
Journal:  Clin Pharmacokinet       Date:  1998-02       Impact factor: 6.447

5.  Quantitative MALDI tandem mass spectrometric imaging of cocaine from brain tissue with a deuterated internal standard.

Authors:  David A Pirman; Richard F Reich; András Kiss; Ron M A Heeren; Richard A Yost
Journal:  Anal Chem       Date:  2012-12-24       Impact factor: 6.986

6.  Evaluation of an accurate mass approach for the simultaneous detection of drug and metabolite distributions via whole-body mass spectrometric imaging.

Authors:  Sheerin K Shahidi-Latham; Sucharita M Dutta; Maria C Prieto Conaway; Patrick J Rudewicz
Journal:  Anal Chem       Date:  2012-08-07       Impact factor: 6.986

7.  Analysis of chloroquine and metabolites directly from whole-body animal tissue sections by liquid extraction surface analysis (LESA) and tandem mass spectrometry.

Authors:  Whitney B Parson; Stormy L Koeniger; Robert W Johnson; Jamie Erickson; Yu Tian; Christopher Stedman; Annette Schwartz; Edit Tarcsa; Roderic Cole; Gary J Van Berkel
Journal:  J Mass Spectrom       Date:  2012-11       Impact factor: 1.982

8.  MSiReader: an open-source interface to view and analyze high resolving power MS imaging files on Matlab platform.

Authors:  Guillaume Robichaud; Kenneth P Garrard; Jeremy A Barry; David C Muddiman
Journal:  J Am Soc Mass Spectrom       Date:  2013-03-28       Impact factor: 3.109

9.  Mass recalibration of FT-ICR mass spectrometry imaging data using the average frequency shift of ambient ions.

Authors:  Jeremy A Barry; Guillaume Robichaud; David C Muddiman
Journal:  J Am Soc Mass Spectrom       Date:  2013-05-29       Impact factor: 3.109

10.  Matrix-assisted laser desorption/ionization imaging mass spectrometry for direct measurement of clozapine in rat brain tissue.

Authors:  Yunsheng Hsieh; Roger Casale; Elaine Fukuda; Jiwen Chen; Ian Knemeyer; Julia Wingate; Richard Morrison; Walter Korfmacher
Journal:  Rapid Commun Mass Spectrom       Date:  2006       Impact factor: 2.419
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  12 in total

1.  Ambient Molecular Analysis of Biological Tissue Using Low-Energy, Femtosecond Laser Vaporization and Nanospray Postionization Mass Spectrometry.

Authors:  Fengjian Shi; Paul M Flanigan; Jieutonne J Archer; Robert J Levis
Journal:  J Am Soc Mass Spectrom       Date:  2015-12-14       Impact factor: 3.109

2.  A Simple Method for Improving the Spatial Resolution in Infrared Laser Ablation Mass Spectrometry Imaging.

Authors:  Juha-Pekka Hieta; Anu Vaikkinen; Samuli Auno; Heikki Räikkönen; Markus Haapala; Gianmario Scotti; Jaakko Kopra; Petteri Piepponen; Tiina J Kauppila
Journal:  J Am Soc Mass Spectrom       Date:  2017-01-11       Impact factor: 3.109

3.  Quantitative mass spectrometry imaging of emtricitabine in cervical tissue model using infrared matrix-assisted laser desorption electrospray ionization.

Authors:  Mark T Bokhart; Elias Rosen; Corbin Thompson; Craig Sykes; Angela D M Kashuba; David C Muddiman
Journal:  Anal Bioanal Chem       Date:  2014-10-16       Impact factor: 4.142

Review 4.  Infrared matrix-assisted laser desorption electrospray ionization mass spectrometry imaging analysis of biospecimens.

Authors:  M T Bokhart; D C Muddiman
Journal:  Analyst       Date:  2016-08-03       Impact factor: 4.616

5.  Mapping antiretroviral drugs in tissue by IR-MALDESI MSI coupled to the Q Exactive and comparison with LC-MS/MS SRM assay.

Authors:  Jeremy A Barry; Guillaume Robichaud; Mark T Bokhart; Corbin Thompson; Craig Sykes; Angela D M Kashuba; David C Muddiman
Journal:  J Am Soc Mass Spectrom       Date:  2014-04-18       Impact factor: 3.109

6.  Silver dopants for targeted and untargeted direct analysis of unsaturated lipids via infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI).

Authors:  Florian Meier; Kenneth P Garrard; David C Muddiman
Journal:  Rapid Commun Mass Spectrom       Date:  2014-11-30       Impact factor: 2.419

Review 7.  Applications of Fourier Transform Ion Cyclotron Resonance (FT-ICR) and Orbitrap Based High Resolution Mass Spectrometry in Metabolomics and Lipidomics.

Authors:  Manoj Ghaste; Robert Mistrik; Vladimir Shulaev
Journal:  Int J Mol Sci       Date:  2016-05-25       Impact factor: 5.923

Review 8.  Fourier Transform Mass Spectrometry: The Transformation of Modern Environmental Analyses.

Authors:  Lucy Lim; Fangzhi Yan; Stephen Bach; Katianna Pihakari; David Klein
Journal:  Int J Mol Sci       Date:  2016-01-14       Impact factor: 5.923

Review 9.  The application of label-free imaging technologies in transdermal research for deeper mechanism revealing.

Authors:  Danping Zhang; Qiong Bian; Yi Zhou; Qiaoling Huang; Jianqing Gao
Journal:  Asian J Pharm Sci       Date:  2020-08-24       Impact factor: 6.598

10.  Yale School of Public Health Symposium on tissue imaging mass spectrometry: illuminating phenotypic heterogeneity and drug disposition at the molecular level.

Authors:  Georgia Charkoftaki; Nicholas J W Rattray; Per E Andrén; Richard M Caprioli; Steve Castellino; Mark W Duncan; Richard J A Goodwin; Kevin L Schey; Sheerin K Shahidi-Latham; Kirill A Veselkov; Caroline H Johnson; Vasilis Vasiliou
Journal:  Hum Genomics       Date:  2018-02-27       Impact factor: 4.639
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