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Literature DB >> 26055377

The enterovirus 3C protease inhibitor SG85 efficiently blocks rhinovirus replication and is not cross-resistant with rupintrivir.

Céline Lacroix¹, Shyla George², Pieter Leyssen¹, Rolf Hilgenfeld³, Johan Neyts⁴.

Abstract

The novel enterovirus protease inhibitor (PI) SG85 effectively inhibits the in vitro replication of 14 rhinoviruses representative of species A and B (median 50% effective concentration, 0.04 μM). A low-level SG85-resistant variant was selected that carried amino acid substitutions S127G and T143A in the 3C protease. Both substitutions are required for low-level resistance to SG85, as demonstrated by reverse genetics. Interestingly, there is no cross-resistance to SG85 and rupintrivir (another PI); a structural explanation is provided for this observation.

Entities: Chemical Mutation

Mesh：

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Year: 2015 PMID： 26055377 PMCID： PMC4538484 DOI： 10.1128/AAC.00534-15

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

22 in total

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Journal: Antimicrob Agents Chemother Date: 2005-06 Impact factor: 5.191

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Authors: Jinzhi Tan; Shyla George; Yuri Kusov; Markus Perbandt; Stefan Anemüller; Jeroen R Mesters; Helene Norder; Bruno Coutard; Céline Lacroix; Pieter Leyssen; Johan Neyts; Rolf Hilgenfeld
Journal: J Virol Date: 2013-02-06 Impact factor: 5.103

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Journal: Antimicrob Agents Chemother Date: 2007-10-01 Impact factor: 5.191

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Journal: Am J Respir Crit Care Med Date: 2010-10-01 Impact factor: 21.405

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Authors: Erin J Walker; Parisa Younessi; Alex J Fulcher; Robert McCuaig; Belinda J Thomas; Philip G Bardin; David A Jans; Reena Ghildyal
Journal: PLoS One Date: 2013-08-07 Impact factor: 3.240

9 in total

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Authors: A Grünewaldt; C Hügel; G G U Rohde
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Authors: Liang Sun; Adam Meijer; Mathy Froeyen; Linlin Zhang; Hendrik Jan Thibaut; Jim Baggen; Shyla George; John Vernachio; Frank J M van Kuppeveld; Pieter Leyssen; Rolf Hilgenfeld; Johan Neyts; Leen Delang
Journal: Antimicrob Agents Chemother Date: 2015-09-14 Impact factor: 5.191

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Authors: Mingyu Zhang; Yong Zhang; Yan Wang; Wanyu Lv; Yanyang Zhang
Journal: Sci Rep Date: 2019-04-15 Impact factor: 4.379

5. Selective Inhibition of Enterovirus A Species Members' Reproduction by Furano[2, 3-d]pyrimidine Nucleosides Revealed by Antiviral Activity Profiling against (+)ssRNA Viruses.

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Journal: ChemistrySelect Date: 2018-02-27 Impact factor: 2.109