Literature DB >> 26054678

Using the comet and micronucleus assays for genotoxicity studies: A review.

Rodrigo Pinheiro Araldi1, Thatiana Corrêa de Melo2, Thais Biude Mendes3, Paulo Luiz de Sá Júnior4, Bruno Heidi Nakano Nozima5, Eliana Tiemi Ito6, Rodrigo Franco de Carvalho4, Edislane Barreiros de Souza6, Rita de Cassia Stocco7.   

Abstract

Physical, chemical and biological agents can act in the DNA, resulting in mutation involved in cancer. Thus, genotoxic tests are required by regulatory agencies in order to evaluate potential risk of cancer. Among these tests, the comet assay (CA) and micronucleus assay (MNA) are the most commonly used. However, there are different protocols and recommendations already published. This is the first review, after the inclusion of CA in S2R1 guidance and OECD 489, which summarizes the main technical recommendations of both CA and MNA.
Copyright © 2015. Published by Elsevier Masson SAS.

Entities:  

Keywords:  Comet assay; Genotoxicity tests; Micronucleus assay; Mutagenesis

Mesh：

Year:  2015        PMID： 26054678     DOI： 10.1016/j.biopha.2015.04.004

Source DB:  PubMed          Journal:  Biomed Pharmacother        ISSN： 0753-3322            Impact factor:   6.529


  35 in total

1.  Cytotoxic and genotoxic effects induced by enrofloxacin-based antibiotic formulation Floxagen® in two experimental models of bovine cells in vitro: peripheral lymphocytes and cumulus cells.

Authors:  Juan Patricio Anchordoquy; Juan Mateo Anchordoquy; Noelia Nikoloff; Rocío Gambaro; Gisel Padula; Cecilia Furnus; Analía Seoane
Journal:  Environ Sci Pollut Res Int       Date:  2018-11-30       Impact factor: 4.223

2.  Aerial pesticide application causes DNA damage in pilots from Sinaloa, Mexico.

Authors:  C Martínez-Valenzuela; S M Waliszewski; O Amador-Muñoz; E Meza; M E Calderón-Segura; E Zenteno; J Huichapan-Martínez; M Caba; R Félix-Gastélum; R Longoria-Espinoza
Journal:  Environ Sci Pollut Res Int       Date:  2016-11-05       Impact factor: 4.223

3.  Combined effects of co-exposure to formaldehyde and acrolein mixtures on cytotoxicity and genotoxicity in vitro.

Authors:  Sen Zhang; Huan Chen; An Wang; Yong Liu; Hongwei Hou; Qingyuan Hu
Journal:  Environ Sci Pollut Res Int       Date:  2018-06-26       Impact factor: 4.223

4.  Health indicators and contaminant levels of a critically endangered species in the Gironde estuary, the European sturgeon.

Authors:  Marie-Laure Acolas; Blandine Davail; Patrice Gonzalez; Séverine Jean; Christelle Clérandeau; Bénédicte Morin; Pierre-Yves Gourves; Guillemine Daffe; Pierre Labadie; Annie Perrault; Mathilde Lauzent; Maud Pierre; Romaric Le Barh; Magalie Baudrimont; Laurent Peluhet; Karyn Le Menach; Hélène Budzinski; Eric Rochard; Jérôme Cachot
Journal:  Environ Sci Pollut Res Int       Date:  2019-04-24       Impact factor: 4.223

5.  Lymphocyte genotoxicity and protective effect of Calyptranthes tricona (Myrtaceae) against H2O2-induced cell death in MCF-7 cells.

Authors:  Débora Mara Kich; Shanna Bitencourt; Bruna Caye; Dalana Faleiro; Celso Alves; Joana Silva; Susete Pinteus; Michelle Mergener; Fernanda Majolo; Aline Augusti Boligon; Roberto Christ Vianna Santos; Rui Pedrosa; Claucia Fernanda Volken de Souza; Márcia Inês Goettert
Journal:  Mol Cell Biochem       Date:  2016-10-04       Impact factor: 3.396

6.  Detection of genotoxic effects of drinking water disinfection by-products using Vicia faba bioassay.

Authors:  Yu Hu; Li Tan; Shao-Hui Zhang; Yu-Ting Zuo; Xue Han; Na Liu; Wen-Qing Lu; Ai-Lin Liu
Journal:  Environ Sci Pollut Res Int       Date:  2016-10-26       Impact factor: 4.223

Review 7.  Zebrafish-An Optimal Model in Experimental Oncology.

Authors:  Iwona Kwiatkowska; Justyna Magdalena Hermanowicz; Zaneta Iwinska; Krystyna Kowalczuk; Jolanta Iwanowska; Dariusz Pawlak
Journal:  Molecules       Date:  2022-06-30       Impact factor: 4.927

8.  Protective effects of purple carrot extract (Daucus carota) against rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.

Authors:  Glaucia Resende Soares; Carolina Foot Gomes de Moura; Marcelo Jose Dias Silva; Wagner Vilegas; Aline Boveto Santamarina; Luciana Pellegrini Pisani; Debora Estadella; Daniel Araki Ribeiro
Journal:  Med Oncol       Date:  2018-03-15       Impact factor: 3.064

9.  Bioavailability of pollutants sets risk of exposure to biota and human population in reservoirs from Iguaçu River (Southern Brazil).

Authors:  F Y Yamamoto; M V M Pereira; E Lottermann; G S Santos; T R O Stremel; H B Doria; P Gusso-Choueri; S X Campos; C F Ortolani-Machado; M M Cestari; F Filipak Neto; J C R Azevedo; C A Oliveira Ribeiro
Journal:  Environ Sci Pollut Res Int       Date:  2016-06-03       Impact factor: 4.223

Review 10.  Applications of CometChip for Environmental Health Studies.

Authors:  Christy Chao; Bevin P Engelward
Journal:  Chem Res Toxicol       Date:  2020-06-10       Impact factor: 3.739
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