Literature DB >> 26054623

How Do US Gastroenterologists Use Over-the-Counter and Prescription Medications in Patients With Gastroesophageal Reflux and Chronic Constipation?

Stacy B Menees1,2, Amanda Guentner3, Samuel W Chey1, Richard Saad1, William D Chey1.   

Abstract

BACKGROUND: The aim of this study was to assess how US gastroenterologists perceive and utilize over-the-counter (OTC) and prescription medications for gastroesophageal reflux disease (GERD) and chronic constipation (CC).
METHODS: A total of 3,600 randomly selected American Gastroenterological Association (AGA) members were mailed a 27-question survey that assessed their perceptions and use of OTC and prescription medications. The χ(2) test and Student's t-test were utilized for bivariate analysis.
RESULTS: A total of 830 gastroenterologists (23.1%) completed the survey. For the typical acid reflux patient, 50% of gastroenterologists recommended OTC proton pump inhibitors (PPIs), 13% recommended an OTC histamine2 receptor antagonist, whereas 33% recommended a prescription PPI. However, in the typical CC patient, 97% of gastroenterologists initially utilized OTC treatments. The vast majority of gastroenterologists felt that OTC brand name and store brand PPIs (76%) and polyethylene glycol (PEG 3350; 90%) were equally effective. Despite this, a minority "always" or "very often" directed their patients to purchase a store brand PPI (35%) or laxative (40%). In addition, gastroenterologists tended to underestimate the cost savings associated with store brand medicines and had limited knowledge regarding the regulation of store brands.
CONCLUSIONS: Among US gastroenterologists, OTC medications now dominate primary therapy of GERD and CC. Despite feeling that name brand and store brand PPIs and laxatives are equally effective, the majority of gastroenterologists recommend brand name medicines and underestimate the cost savings associated with store brands. In this age of accountable care, greater efforts to help physicians and patients to better utilize their health-care dollars is warranted.

Entities:  

Mesh:

Substances:

Year:  2015        PMID: 26054623     DOI: 10.1038/ajg.2015.156

Source DB:  PubMed          Journal:  Am J Gastroenterol        ISSN: 0002-9270            Impact factor:   10.864


  14 in total

1.  The elimination of selected drug products from the Michigan Medicaid formulary: a case study.

Authors:  D M Smith; P L McKercher
Journal:  Hosp Formul       Date:  1984-05

2.  Onset of action during on-demand treatment with maalox suspension or low-dose ranitidine for heartburn.

Authors:  R A Faaij; J M Van Gerven; I Jolivet-Landreau; A A Masclee; E M Vendrig; R C Schoemaker; L D Jacobs; A F Cohen
Journal:  Aliment Pharmacol Ther       Date:  1999-12       Impact factor: 8.171

3.  American Gastroenterological Association Medical Position Statement on the management of gastroesophageal reflux disease.

Authors:  Peter J Kahrilas; Nicholas J Shaheen; Michael F Vaezi; Stephen W Hiltz; Edgar Black; Irvin M Modlin; Steve P Johnson; John Allen; Joel V Brill
Journal:  Gastroenterology       Date:  2008-10       Impact factor: 22.682

4.  Guidelines for the diagnosis and management of gastroesophageal reflux disease.

Authors:  Philip O Katz; Lauren B Gerson; Marcelo F Vela
Journal:  Am J Gastroenterol       Date:  2013-02-19       Impact factor: 10.864

Review 5.  How drugs are developed and approved by the FDA: current process and future directions.

Authors:  Arthur A Ciociola; Lawrence B Cohen; Prasad Kulkarni
Journal:  Am J Gastroenterol       Date:  2014-05       Impact factor: 10.864

6.  Management of heartburn in a large, randomized, community-based study: comparison of four therapeutic strategies.

Authors:  C W Howden; J M Henning; B Huang; N Lukasik; J W Freston
Journal:  Am J Gastroenterol       Date:  2001-06       Impact factor: 10.864

7.  Time to relief of episodic symptoms of gastro-oesophageal reflux disease. A crossover comparison of single doses of the effervescent and standard formulations of ranitidine.

Authors:  M Elm; P Hellke; K Andrén; G Dahl; A L Nyth
Journal:  Scand J Gastroenterol       Date:  1998-09       Impact factor: 2.423

8.  Ambulatory care for constipation in the United States, 1993-2004.

Authors:  Nilay D Shah; Denesh K Chitkara; G Richard Locke; Patrick D Meek; Nicholas J Talley
Journal:  Am J Gastroenterol       Date:  2008-06-28       Impact factor: 10.864

9.  "Proton-pump inhibitor-first" strategy versus "step-up" strategy for the acute treatment of reflux esophagitis: a cost-effectiveness analysis in Japan.

Authors:  Yasuki Habu; Kazuo Maeda; Takeo Kusuda; Takuya Yoshino; Seiji Shio; Maki Yamazaki; Takanobu Hayakumo; Kyohei Hayashi; Yoshiyuki Watanabe; Keiichi Kawai
Journal:  J Gastroenterol       Date:  2005-11       Impact factor: 6.772

View more
  12 in total

Review 1.  Intractable Constipation in the Elderly.

Authors:  Noemi Baffy; Amy E Foxx-Orenstein; Lucinda A Harris; Susan Sterler
Journal:  Curr Treat Options Gastroenterol       Date:  2017-09

2.  Proton Pump Inhibitor Use, H2-Receptor Antagonist Use, and Risk of Incident Clinical Vertebral Fracture in Women.

Authors:  Julie M Paik; Harold N Rosen; Catherine M Gordon; Gary C Curhan
Journal:  Calcif Tissue Int       Date:  2018-05-12       Impact factor: 4.333

3.  The Association between Prebiotic Fiber Supplement Use and Colorectal Cancer Risk and Mortality in the Women's Health Initiative.

Authors:  Meghan B Skiba; Lindsay N Kohler; Tracy E Crane; Elizabeth T Jacobs; Aladdin H Shadyab; Ikuko Kato; Linda Snetselaar; Lihong Qi; Cynthia A Thomson
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2019-08-27       Impact factor: 4.254

4.  Laxative use in patients with advanced chronic kidney disease transitioning to dialysis.

Authors:  Keiichi Sumida; Ankur A Dashputre; Praveen K Potukuchi; Fridtjof Thomas; Yoshitsugu Obi; Miklos Z Molnar; Justin D Gatwood; Elani Streja; Kamyar Kalantar-Zadeh; Csaba P Kovesdy
Journal:  Nephrol Dial Transplant       Date:  2021-11-09       Impact factor: 5.992

5.  Chronic constipation in the elderly: a primer for the gastroenterologist.

Authors:  Roberto De Giorgio; Eugenio Ruggeri; Vincenzo Stanghellini; Leonardo H Eusebi; Franco Bazzoli; Giuseppe Chiarioni
Journal:  BMC Gastroenterol       Date:  2015-10-14       Impact factor: 3.067

6.  Country-wide medical records infer increased allergy risk of gastric acid inhibition.

Authors:  Galateja Jordakieva; Michael Kundi; Eva Untersmayr; Isabella Pali-Schöll; Berthold Reichardt; Erika Jensen-Jarolim
Journal:  Nat Commun       Date:  2019-07-30       Impact factor: 14.919

7.  Lessons learned: Chronic idiopathic constipation patient experiences with over-the-counter medications.

Authors:  Brian E Lacy; Elizabeth P Shea; Machelle Manuel; Jessica L Abel; Hancheng Jiang; Douglas C A Taylor
Journal:  PLoS One       Date:  2021-01-11       Impact factor: 3.240

Review 8.  Effective and safe proton pump inhibitor therapy in acid-related diseases - A position paper addressing benefits and potential harms of acid suppression.

Authors:  Carmelo Scarpignato; Luigi Gatta; Angelo Zullo; Corrado Blandizzi
Journal:  BMC Med       Date:  2016-11-09       Impact factor: 8.775

Review 9.  Recent advances in understanding and managing chronic constipation.

Authors:  David O Prichard; Adil E Bharucha
Journal:  F1000Res       Date:  2018-10-15

Review 10.  Constipation in CKD.

Authors:  Keiichi Sumida; Kunihiro Yamagata; Csaba P Kovesdy
Journal:  Kidney Int Rep       Date:  2019-11-13
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.