Literature DB >> 26052551

Retinal phagocytes in age-related macular degeneration.

Soo-Young Kim1.   

Abstract

Age-related macular degeneration (AMD) is the leading cause of blindness in industrial countries. Vision loss caused by AMD results from geographic atrophy (dry AMD) and/or choroidal neovascularization (wet AMD). Presently, the etiology and pathogenesis of AMD is not fully understood and there is no effective treatment. Oxidative stress in retinal pigment epithelial (RPE) cells is considered to be one of the major factors contributing to the pathogenesis of AMD. Also retinal glia, as scavengers, are deeply related with diseases and could play a role. Therefore, therapeutic approaches for microglia and Müller glia, as well as RPE, may lead to new strategies for AMD treatment. This review summarizes the pathological findings observed in RPE cells, microglia and Müller glia of AMD murine models.

Entities:  

Keywords:  Age-related macular degeneration; Müller glia; microglia; retinal pigment epithelium

Year:  2015        PMID： 26052551      PMCID： PMC4457466          DOI： 10.14800/macrophage.698

Source DB:  PubMed          Journal:  Macrophage (Houst)        ISSN： 2378-136X


  71 in total

1.  Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane.

Authors:  Paul Hahn; Ann H Milam; Joshua L Dunaief
Journal:  Arch Ophthalmol       Date:  2003-08

2.  Apolipoprotein localization in isolated drusen and retinal apolipoprotein gene expression.

Authors:  Chuan-Ming Li; Mark E Clark; Melissa F Chimento; Christine A Curcio
Journal:  Invest Ophthalmol Vis Sci       Date:  2006-07       Impact factor: 4.799

3.  Vascular endothelial growth factor is present in glial cells of the retina and optic nerve of human subjects with nonproliferative diabetic retinopathy.

Authors:  R H Amin; R N Frank; A Kennedy; D Eliott; J E Puklin; G W Abrams
Journal:  Invest Ophthalmol Vis Sci       Date:  1997-01       Impact factor: 4.799

4.  Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: implications for the process of drusen formation.

Authors:  D H Anderson; S Ozaki; M Nealon; J Neitz; R F Mullins; G S Hageman; L V Johnson
Journal:  Am J Ophthalmol       Date:  2001-06       Impact factor: 5.258

5.  Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells.

Authors:  G S Hageman; R F Mullins; S R Russell; L V Johnson; D H Anderson
Journal:  FASEB J       Date:  1999-03       Impact factor: 5.191

Review 6.  A role for local inflammation in the formation of drusen in the aging eye.

Authors:  Don H Anderson; Robert F Mullins; Gregory S Hageman; Lincoln V Johnson
Journal:  Am J Ophthalmol       Date:  2002-09       Impact factor: 5.258

7.  Vascular endothelial growth factor as an autocrine survival factor for retinal pigment epithelial cells under oxidative stress via the VEGF-R2/PI3K/Akt.

Authors:  Suk Ho Byeon; Sung Chul Lee; Soo Hyun Choi; Hyung-Keun Lee; Joon H Lee; Young Kwang Chu; Oh Woong Kwon
Journal:  Invest Ophthalmol Vis Sci       Date:  2009-10-15       Impact factor: 4.799

8.  Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.

Authors:  Christopher N Parkhurst; Guang Yang; Ipe Ninan; Jeffrey N Savas; John R Yates; Juan J Lafaille; Barbara L Hempstead; Dan R Littman; Wen-Biao Gan
Journal:  Cell       Date:  2013-12-19       Impact factor: 41.582

9.  Ten-year incidence and progression of age-related maculopathy: The Beaver Dam eye study.

Authors:  Ronald Klein; Barbara E K Klein; Sandra C Tomany; Stacy M Meuer; Guan-Hua Huang
Journal:  Ophthalmology       Date:  2002-10       Impact factor: 12.079

10.  CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.

Authors:  Christophe Combadière; Charles Feumi; William Raoul; Nicole Keller; Mathieu Rodéro; Adeline Pézard; Sophie Lavalette; Marianne Houssier; Laurent Jonet; Emilie Picard; Patrice Debré; Mirna Sirinyan; Philippe Deterre; Tania Ferroukhi; Salomon-Yves Cohen; Dominique Chauvaud; Jean-Claude Jeanny; Sylvain Chemtob; Francine Behar-Cohen; Florian Sennlaub
Journal:  J Clin Invest       Date:  2007-10       Impact factor: 14.808
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  6 in total

1.  Photoreceptor disc shedding in the living human eye.

Authors:  Omer P Kocaoglu; Zhuolin Liu; Furu Zhang; Kazuhiro Kurokawa; Ravi S Jonnal; Donald T Miller
Journal:  Biomed Opt Express       Date:  2016-10-13       Impact factor: 3.732

Review 2.  [Atrophy of the macula in the context of its wet, age-related degeneration : An inescapable consequence of anti-VEGF therapy?]

Authors:  J G Garweg
Journal:  Ophthalmologe       Date:  2016-12       Impact factor: 1.059

3.  Contributions of age-related alterations of the retinal pigment epithelium and of glia to the AMD-like pathology in OXYS rats.

Authors:  Darya V Telegina; Oyuna S Kozhevnikova; Sergey I Bayborodin; Nataliya G Kolosova
Journal:  Sci Rep       Date:  2017-01-30       Impact factor: 4.379

4.  Correlative light and immuno-electron microscopy of retinal tissue cryostat sections.

Authors:  Thomas Burgoyne; Amelia Lane; William E Laughlin; Michael E Cheetham; Clare E Futter
Journal:  PLoS One       Date:  2018-01-09       Impact factor: 3.240

5.  RPE phagocytic function declines in age-related macular degeneration and is rescued by human umbilical tissue derived cells.

Authors:  George Inana; Christopher Murat; Weijun An; Xiang Yao; Ian R Harris; Jing Cao
Journal:  J Transl Med       Date:  2018-03-13       Impact factor: 5.531

6.  Blockade of microglial adenosine A2A receptor impacts inflammatory mechanisms, reduces ARPE-19 cell dysfunction and prevents photoreceptor loss in vitro.

Authors:  M H Madeira; K Rashid; A F Ambrósio; A R Santiago; T Langmann
Journal:  Sci Rep       Date:  2018-02-02       Impact factor: 4.379
  6 in total

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