Literature DB >> 26052384

Chemokines and their receptors play important roles in the development of hepatocellular carcinoma.

Chun-Min Liang1, Long Chen1, Heng Hu1, Hui-Ying Ma1, Ling-Ling Gao1, Jie Qin1, Cui-Ping Zhong1.   

Abstract

The chemokine system consists of four different subclasses with over 50 chemokines and 19 receptors. Their functions in the immune system have been well elucidated and research during the last decades unveils their new roles in hepatocellular carcinoma (HCC). The chemokines and their receptors in the microenvironment influence the development of HCC by several aspects including: inflammation, effects on immune cells, angiogenesis, and direct effects on HCC cells. Regarding these aspects, pre-clinical research by targeting the chemokine system has yielded promising data, and these findings bring us new clues in the chemokine-based therapies for HCC.

Entities:  

Keywords:  Angiogenesis; Chemokine receptors; Chemokines; Hepatocellular carcinoma; Immune cells; Inflammation; Treatments; Tumor behaviors

Year:  2015        PMID： 26052384      PMCID： PMC4450202          DOI： 10.4254/wjh.v7.i10.1390

Source DB:  PubMed          Journal:  World J Hepatol


  123 in total

Review 1.  Macrophage plasticity and polarization: in vivo veritas.

Authors:  Antonio Sica; Alberto Mantovani
Journal:  J Clin Invest       Date:  2012-03-01       Impact factor: 14.808

Review 2.  Chemokines and their role in tumor growth and metastasis.

Authors:  J M Wang; X Deng; W Gong; S Su
Journal:  J Immunol Methods       Date:  1998-11-01       Impact factor: 2.303

3.  Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression.

Authors:  Xiaoqin Yang; Peirong Lu; Chifumi Fujii; Yasunari Nakamoto; Ji-Liang Gao; Shuichi Kaneko; Philip M Murphy; Naofumi Mukaida
Journal:  Int J Cancer       Date:  2006-04-15       Impact factor: 7.396

4.  Prolonged, NK cell-mediated antitumor effects of suicide gene therapy combined with monocyte chemoattractant protein-1 against hepatocellular carcinoma.

Authors:  Tomoya Tsuchiyama; Yasunari Nakamoto; Yoshio Sakai; Yohei Marukawa; Masaaki Kitahara; Naofumi Mukaida; Shuichi Kaneko
Journal:  J Immunol       Date:  2007-01-01       Impact factor: 5.422

5.  Tumor-activated monocytes promote expansion of IL-17-producing CD8+ T cells in hepatocellular carcinoma patients.

Authors:  Dong-Ming Kuang; Chen Peng; Qiyi Zhao; Yan Wu; Ling-Yan Zhu; Jianen Wang; Xiao-Yu Yin; Lian Li; Limin Zheng
Journal:  J Immunol       Date:  2010-06-25       Impact factor: 5.422

6.  Chemokine CCL3 facilitates the migration of hepatoma cells by changing the concentration intracellular Ca.

Authors:  Yufeng Yuan; Jun Liu; Zhisu Liu; Yueming He; Zhonglin Zhang; Congqing Jiang; Qun Qian
Journal:  Hepatol Res       Date:  2010-03-04       Impact factor: 4.288

7.  Molecular fingerprinting and autocrine growth regulation of endothelial cells in a murine model of hepatocellular carcinoma.

Authors:  Eduard Ryschich; Paulius Lizdenis; Carina Ittrich; Axel Benner; Simone Stahl; Alf Hamann; Jan Schmidt; Percy Knolle; Bernd Arnold; Günter J Hämmerling; Ruth Ganss
Journal:  Cancer Res       Date:  2006-01-01       Impact factor: 12.701

8.  Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice.

Authors:  Neta Barashi; Ido D Weiss; Ori Wald; Hanna Wald; Katia Beider; Michal Abraham; Shiri Klein; Daniel Goldenberg; Jonathan Axelrod; Eli Pikarsky; Rinat Abramovitch; Evelyne Zeira; Eithan Galun; Amnon Peled
Journal:  Hepatology       Date:  2013-07-12       Impact factor: 17.425

9.  Expression of the CXCR3 ligand I-TAC by hepatocytes in chronic hepatitis C and its correlation with hepatic inflammation.

Authors:  Karla J Helbig; Andrew Ruszkiewicz; Ljiljana Semendric; Hugh A J Harley; Shaun R McColl; Michael R Beard
Journal:  Hepatology       Date:  2004-05       Impact factor: 17.425

10.  Management of hepatocellular carcinoma: an update.

Authors:  Jordi Bruix; Morris Sherman
Journal:  Hepatology       Date:  2011-03       Impact factor: 17.425
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  22 in total

Review 1.  Systems Challenges of Hepatic Carcinomas: A Review.

Authors:  Dhatri Madduru; Johny Ijaq; Sujata Dhar; Saumyadip Sarkar; Naresh Poondla; Partha S Das; Silvia Vasquez; Prashanth Suravajhala
Journal:  J Clin Exp Hepatol       Date:  2018-05-17

2.  The Diagnostic Value of Chemokine/Chemokine Receptor Pairs in Hepatocellular Carcinoma and Colorectal Liver Metastasis.

Authors:  Xiaolei Jiao; Guiming Shu; Hui Liu; Qin Zhang; Zhe Ma; Chaoyi Ren; Hongsheng Guo; Jingxiang Shi; Junguo Liu; Chuanshan Zhang; Yijun Wang; Yingtang Gao
Journal:  J Histochem Cytochem       Date:  2019-01-11       Impact factor: 2.479

Review 3.  EMT and Inflammation: Crossroads in HCC.

Authors:  Burcu Sengez; Brian I Carr; Hani Alotaibi
Journal:  J Gastrointest Cancer       Date:  2022-01-12

4.  Differential expression of Tim-3, PD-1, and CCR5 on peripheral T and B lymphocytes in hepatitis C virus-related hepatocellular carcinoma and their impact on treatment outcomes.

Authors:  Asmaa M Zahran; Helal F Hetta; Amal Rayan; Abeer Sharaf Eldin; Elham Ahmed Hassan; Hussein Fakhry; Ahmed Soliman; Omnia El-Badawy
Journal:  Cancer Immunol Immunother       Date:  2020-03-13       Impact factor: 6.968

Review 5.  Inflammatory microenvironment contributes to epithelial-mesenchymal transition in gastric cancer.

Authors:  Hui-Ying Ma; Xin-Zhou Liu; Chun-Min Liang
Journal:  World J Gastroenterol       Date:  2016-08-07       Impact factor: 5.742

6.  Discovery of small molecule antagonists of chemokine receptor CXCR6 that arrest tumor growth in SK-HEP-1 mouse xenografts as a model of hepatocellular carcinoma.

Authors:  Satyamaheshwar Peddibhotla; Paul M Hershberger; R Jason Kirby; Eliot Sugarman; Patrick R Maloney; E Hampton Sessions; Daniela Divlianska; Camilo J Morfa; David Terry; Anthony B Pinkerton; Layton H Smith; Siobhan Malany
Journal:  Bioorg Med Chem Lett       Date:  2019-12-17       Impact factor: 2.823

7.  Correlation between CXCR4/CXCR7/CXCL12 chemokine axis expression and prognosis in lymph-node-positive lung cancer patients.

Authors:  Masakazu Katsura; Fumihiro Shoji; Tatsuro Okamoto; Shinichiro Shimamatsu; Fumihiko Hirai; Gouji Toyokawa; Yosuke Morodomi; Tetsuzo Tagawa; Yoshinao Oda; Yoshihiko Maehara
Journal:  Cancer Sci       Date:  2017-11-09       Impact factor: 6.716

8.  Microarray analysis for the identification of specific proteins and functional modules involved in the process of hepatocellular carcinoma originating from cirrhotic liver.

Authors:  Wufeng Fan; Guangming Ye
Journal:  Mol Med Rep       Date:  2018-02-02       Impact factor: 2.952

9.  TAM Infiltration Differences in "Tumor-First" and " ZHENG-First" Models and the Underlying Inflammatory Molecular Mechanism in Pancreatic Cancer.

Authors:  Feng-Jiao Wang; Peng Wang; Lian-Yu Chen; Ya-Wen Geng; Hao Chen; Zhi-Qiang Meng; Lu-Ming Liu; Zhen Chen
Journal:  Integr Cancer Ther       Date:  2018-04-22       Impact factor: 3.279

10.  Blocking the CCL5-CCR5 Axis Using Maraviroc Promotes M1 Polarization of Macrophages Cocultured with Irradiated Hepatoma Cells.

Authors:  Yuan Zhuang; Xiaomei Zhao; Baoying Yuan; Zhaochong Zeng; Yixing Chen
Journal:  J Hepatocell Carcinoma       Date:  2021-06-18
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