| Literature DB >> 26051476 |
Lei Zhang1, Jianping Lei, Fengjiao Ma, Pinghua Ling, Jintong Liu, Huangxian Ju.
Abstract
A photosensitized and caspase-responsive multifunctional nanoprobe was designed by assembling a porphyrin, a folate targeting-motif and a dye-labelled peptide in a metal-organic framework (MOF) cage, which significantly increases the singlet oxygen quantum yield of porphyrin by 6.2 times, and achieves high efficient cancer therapy and in situ therapeutic monitoring with caspase-3 activation. The integration of theranostic functions in a single nanocarrier holds great promise in precision cancer diagnosis and treatment.Entities:
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Year: 2015 PMID： 26051476 DOI： 10.1039/c5cc03028e
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222