| Literature DB >> 26050882 |
Lili Wang1, Shanshan Li1, Peixiao Tang1, Jin Yan1, Kailin Xu1, Hui Li2.
Abstract
β-Cyclodextrin (β-CD) and 2,6-di-O-methyl-β-cyclodextrin (DM-β-CD) inclusion complexes with riluzole (RLZ) were prepared to improve water solubility and broaden potential pharmaceutical applications. CDs/RLZ inclusion complexes were confirmed via phase solubility studies, FT-IR spectroscopy, PXRD, DSC, (1)H NMR, and SEM. Phase solubility studies indicated that β-CD and DM-β-CD can form 1:1 inclusion complexes with RLZ, and the stability constants were 663.17 and 1609.07M(-1), respectively. Water solubility and dissolution rate of RLZ were significantly improved in complex forms, implying that the inclusion complexes may develop pharmaceutical applications. Preliminary in vitro cytotoxicity assay also showed that RLZ hepatotoxicity was not increased in the inclusion complexes.Entities:
Keywords: 2 ;6-Di-O-methyl-β-cyclodextrin; 2,6-Di-O-methyl-β-cyclodextrin (PubChem CID: 10171019); Dimethyl sulfoxide (PubChem CID: 679); Ethanol (PubChem CID: 702); Hepatotoxicity; Inclusion complex; Methanol (PubChem CID: 887); Riluzole; Riluzole (PubChem CID: 5070); Solubilization; β-Cyclodextrin; β-Cyclodextrin (PubChem CID: 444041)
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Year: 2015 PMID： 26050882 DOI： 10.1016/j.carbpol.2015.04.046
Source DB: PubMed Journal: Carbohydr Polym ISSN： 0144-8617 Impact factor: 9.381