Literature DB >> 26047925

The magnetic resonance aspect of a polyurethane meniscal scaffold is worse in advanced cartilage defects without deterioration of clinical outcomes after a minimum two-year follow-up.

Pablo Eduardo Gelber1, Alexandru Mihai Petrica2, Anna Isart3, Raquel Mari-Molina4, Juan Carlos Monllau5.   

Abstract

BACKGROUND: Meniscal scaffolding is thought to provide functional improvement and to prevent cartilage degeneration. Advanced chondral injuries might damage the scaffold structural properties.
OBJECTIVE: To evaluate the influence of different degrees of articular chondral injuries on the imaging aspect of a polyurethane meniscal scaffold (Actifit®).
METHODS: Fifty-four patients operated on with an Actifit® were studied. The status of the articular cartilage in the involved compartment was classified according to ICRS. The characteristics of the implant were evaluated in MRI with the Genovese score. Functional scores included WOMET, IKDC and Kujala scores. The Genovese score was correlated with the degree of chondral injury and functional results.
RESULTS: The mean follow-up was 39 months (range 25-63). Additional procedures were performed in 69.5%. There were 19 patients without chondral injuries and 14 with grade 1, 10 with grade 3 and eight with grade 4 chondral lesions. The morphology and size of the implant on MRI scanning were worse with a higher degree of chondral injury (p=0.023). WOMET, IKDC and Kujala improved from 36.2SD ±7.6, 32.3SD ±13.5 and 39.2SD ±8.1 to 75.8SD ±12.9 (p=0.02), 75.5SD ±15.4 (p=0.03) and 85.6SD ±13.4 (0.042), respectively. There was no relationship between the severity of chondral injury and functional scores.
CONCLUSIONS: Patients without chondral injuries showed a better MRI aspect of the polyurethane scaffold in terms of size and morphology. By optimizing biomechanics, in particular the implantation of a meniscal substitute, significant pain relief and functional improvement were observed after a minimum two-year follow-up. LEVEL OF EVIDENCE: Therapeutic case series; level 4.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Actifit; Knee; Meniscal substitution; Meniscus; Scaffold

Mesh:

Substances:

Year:  2015        PMID: 26047925     DOI: 10.1016/j.knee.2015.01.008

Source DB:  PubMed          Journal:  Knee        ISSN: 0968-0160            Impact factor:   2.199


  13 in total

1.  Polyurethane-based cell-free scaffold for the treatment of painful partial meniscus loss.

Authors:  G Filardo; E Kon; F Perdisa; A Sessa; A Di Martino; M Busacca; S Zaffagnini; M Marcacci
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2016-07-09       Impact factor: 4.342

2.  Polyurethane meniscal scaffolds lead to better clinical outcomes but worse articular cartilage status and greater absolute meniscal extrusion.

Authors:  Young-Soo Shin; Hoon-Nyun Lee; Hyun-Bo Sim; Hyun-Jung Kim; Dae-Hee Lee
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2017-07-26       Impact factor: 4.342

3.  Muscle strength but not balance improves after arthroscopic biodegradable polyurethane meniscus scaffold application.

Authors:  M Akkaya; S Gursoy; N Ozberk; M E Simsek; F Korkusuz; M Bozkurt
Journal:  Musculoskelet Surg       Date:  2020-09-22

4.  Regeneration of meniscal avascular zone using autogenous meniscal fragments in a rabbit model.

Authors:  Yan Deng; Zuo-Ming Tong; Zhu Dai; Zhi-Wei Chen
Journal:  BMC Surg       Date:  2022-05-28       Impact factor: 2.030

Review 5.  Similar clinical outcomes following collagen or polyurethane meniscal scaffold implantation: a systematic review.

Authors:  Darby A Houck; Matthew J Kraeutler; John W Belk; Eric C McCarty; Jonathan T Bravman
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2018-01-16       Impact factor: 4.342

Review 6.  No differences in clinical outcome between CMI and Actifit meniscal scaffolds: a systematic review and meta-analysis.

Authors:  Davide Reale; Davide Previtali; Luca Andriolo; Alberto Grassi; Christian Candrian; Stefano Zaffagnini; Giuseppe Filardo
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2021-04-16       Impact factor: 4.342

7.  Clinical application of polyurethane meniscal scaffold: A meta-analysis.

Authors:  Wei Li; Jianying Pan; Jintao Li; Jinshan Guo; Chun Zeng; Denghui Xie
Journal:  J Orthop       Date:  2021-02-20

8.  Meniscal polyurethane scaffold plus cartilage repair in post meniscectomy syndrome patients without malalignment improves clinical outcomes at mid-term follow-up.

Authors:  David Figueroa; Francisco Figueroa; Rafael Calvo; Carlos Gomez; Alex Vaisman
Journal:  J Clin Orthop Trauma       Date:  2020-11-14

9.  First Clinical Application of Polyurethane Meniscal Scaffolds with Mesenchymal Stem Cells and Assessment of Cartilage Quality with T2 Mapping at 12 Months.

Authors:  Anell Olivos-Meza; Francisco Javier Pérez Jiménez; Julio Granados-Montiel; Carlos Landa-Solís; Socorro Cortés González; Cesar Alejandro Jiménez Aroche; Marco Valdez Chávez; Saúl Renán León; Ricardo Gomez-Garcia; Valentin Martínez-López; Carmina Ortega-Sánchez; Carmen Parra-Cid; Cristina Velasquillo Martinez; Clemente Ibarra
Journal:  Cartilage       Date:  2019-08-07       Impact factor: 3.117

10.  Development of a Chinese version of the Western Ontario Meniscal Evaluation Tool: cross-cultural adaptation and psychometric evaluation.

Authors:  W W Tong; W Wang; W D Xu
Journal:  J Orthop Surg Res       Date:  2016-08-15       Impact factor: 2.359

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