Literature DB >> 26046568

Binding time--not just affinity--gains stature in drug design.

Wudan Yan.   

Abstract

Mesh:

Year:  2015        PMID: 26046568     DOI: 10.1038/nm0615-545

Source DB:  PubMed          Journal:  Nat Med        ISSN: 1078-8956            Impact factor:   53.440


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  3 in total

Review 1.  Drug-target residence time and its implications for lead optimization.

Authors:  Robert A Copeland; David L Pompliano; Thomas D Meek
Journal:  Nat Rev Drug Discov       Date:  2006-08-04       Impact factor: 84.694

2.  A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands.

Authors:  David C Swinney; Paul Beavis; Kai-Ting Chuang; Yue Zheng; Ina Lee; Peter Gee; Jerome Deval; David M Rotstein; Marianna Dioszegi; Palani Ravendran; Jun Zhang; Surya Sankuratri; Rama Kondru; Georges Vauquelin
Journal:  Br J Pharmacol       Date:  2014-07       Impact factor: 8.739

3.  Translating slow-binding inhibition kinetics into cellular and in vivo effects.

Authors:  Grant K Walkup; Zhiping You; Philip L Ross; Eleanor K H Allen; Fereidoon Daryaee; Michael R Hale; John O'Donnell; David E Ehmann; Virna J A Schuck; Ed T Buurman; Allison L Choy; Laurel Hajec; Kerry Murphy-Benenato; Valerie Marone; Sara A Patey; Lena A Grosser; Michele Johnstone; Stephen G Walker; Peter J Tonge; Stewart L Fisher
Journal:  Nat Chem Biol       Date:  2015-04-20       Impact factor: 15.040

  3 in total
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1.  Engineered Multivalency Enhances Affibody-Based HER3 Inhibition and Downregulation in Cancer Cells.

Authors:  John S Schardt; Jinan M Oubaid; Sonya C Williams; James L Howard; Chloe M Aloimonos; Michelle L Bookstaver; Tek N Lamichhane; Sonja Sokic; Mariya S Liyasova; Maura O'Neill; Thorkell Andresson; Arif Hussain; Stanley Lipkowitz; Steven M Jay
Journal:  Mol Pharm       Date:  2017-03-08       Impact factor: 4.939

Review 2.  Advances and Insights of APC-Asef Inhibitors for Metastatic Colorectal Cancer Therapy.

Authors:  Xiuyan Yang; Jie Zhong; Qiufen Zhang; Li Feng; Zhen Zheng; Jian Zhang; Shaoyong Lu
Journal:  Front Mol Biosci       Date:  2021-04-22
  2 in total

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