A Garcia-Blanca1, A Aranda2, N Blanca-Lopez1, D Perez1, F Gomez3, C Mayorga2, M J Torres3, A Diaz-Perales4, J R Perkins2, M Villalba5, M Blanca3, G Canto1. 1. Allergy Service, Infanta Leonor Hospital, Madrid, Spain. 2. Research Laboratory, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain. 3. Allergy UGC, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain. 4. Plant Biotechnology Institute (UPM-INIA), Madrid, Spain. 5. Biochemistry and Molecular Biology Department, University Complutense Madrid, Madrid, Spain.
Abstract
BACKGROUND: Peanut allergens are common triggers of food allergy. Analyses of sensitization patterns, relationships with other allergens, clinical symptoms, and variation with age are needed. We studied sensitization to Ara h 2, Ara h 9, and Pru p 3 in a peanut allergic children/adolescents and the relationship with peach and pollen. METHODS: Peanut allergic patients aged between 1 and 20 years old were classified into two groups: A) allergic to peanut only and B) allergic to peach and peanut. The IgE response was measured to Ara h 2, Ara h 9, and Pru p 3. RESULTS: Of 964 subjects evaluated, 28% were allergic to peanut. From this group, 68% were also sensitized to pollen. Urticaria was the most frequent entity followed by anaphylaxis and OAS. Fifty-eight percent had Ara h 2- and/or Ara h 9-specific IgE. More than half reported symptoms with peanut alone (Group A) and 35% to peanut and peach (Group B). We observed significant differences in sex, age, onset of symptoms, and sensitization to Artemisia between groups. IgE response to Ara h 2 was more frequent in Group A, and Ara h 9 and Pru p 3 in Group B. We observed a decrease in sensitization to Ara h 2 and an increase to Ara h 9 and Pru p 3 with increasing age. CONCLUSION: Peanut allergy is frequent in subjects with allergy to plant foods, with Ara h 2 and Ara h 9 being two important allergens. In younger patients, Ara h 2 predominates over Ara h 9. The reverse was observed in older patients.
BACKGROUND:Peanut allergens are common triggers of food allergy. Analyses of sensitization patterns, relationships with other allergens, clinical symptoms, and variation with age are needed. We studied sensitization to Ara h 2, Ara h 9, and Pru p 3 in a peanut allergic children/adolescents and the relationship with peach and pollen. METHODS:Peanut allergic patients aged between 1 and 20 years old were classified into two groups: A) allergic to peanut only and B) allergic to peach and peanut. The IgE response was measured to Ara h 2, Ara h 9, and Pru p 3. RESULTS: Of 964 subjects evaluated, 28% were allergic to peanut. From this group, 68% were also sensitized to pollen. Urticaria was the most frequent entity followed by anaphylaxis and OAS. Fifty-eight percent had Ara h 2- and/or Ara h 9-specific IgE. More than half reported symptoms with peanut alone (Group A) and 35% to peanut and peach (Group B). We observed significant differences in sex, age, onset of symptoms, and sensitization to Artemisia between groups. IgE response to Ara h 2 was more frequent in Group A, and Ara h 9 and Pru p 3 in Group B. We observed a decrease in sensitization to Ara h 2 and an increase to Ara h 9 and Pru p 3 with increasing age. CONCLUSION:Peanutallergy is frequent in subjects with allergy to plant foods, with Ara h 2 and Ara h 9 being two important allergens. In younger patients, Ara h 2 predominates over Ara h 9. The reverse was observed in older patients.
Authors: Corinne Keet; Mihaela Plesa; Daria Szelag; Wayne Shreffler; Robert Wood; Joan Dunlop; Roger Peng; Jennifer Dantzer; Robert G Hamilton; Alkis Togias; Michael Pistiner Journal: J Allergy Clin Immunol Date: 2021-01-19 Impact factor: 10.793
Authors: Rebecca Czolk; Julia Klueber; Martin Sørensen; Paul Wilmes; Françoise Codreanu-Morel; Per Stahl Skov; Christiane Hilger; Carsten Bindslev-Jensen; Markus Ollert; Annette Kuehn Journal: Front Immunol Date: 2021-01-28 Impact factor: 7.561