Jun Ho Lee1, Joong Seob Lee1, Dong-Kyu Kim1, Chan Hum Park1, Hae Ran Lee2. 1. Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea. ; Nano-Bio Regenerative Medical Institute, Hallym University, Chuncheon, Korea. 2. Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
Abstract
OBJECTIVES: The silk patch is a thin transparent patch that is produced from silk fibroin. In this study, we investigated the treatment effects of the silk patch in patients with traumatic tympanic membrane perforation (TTMP). METHODS: The closure rate, otorrhea rate, and closure time in all patients and the closure time in successful patients were compared between the paper patch and silk patch groups. RESULTS: Demographic data (gender, site, age, traumatic duration, preoperative air-bone gap, and perforation size and location) were not significantly different between the two groups. The closure rate and otorrhea rate were not significantly different between the two groups. However, the closure time was different between the two groups (closure time of all patients, P=0.031; closure time of successful patients, P=0.037). CONCLUSION: The silk patch which has transparent, elastic, adhesive, and hyper-keratinizing properties results in a more efficient closure time than the paper patch in the treatment of TTMP patients. We therefore believe that the silk patch should be recommended for the treatment of acute tympanic membrane perforation.
OBJECTIVES: The silk patch is a thin transparent patch that is produced from silk fibroin. In this study, we investigated the treatment effects of the silk patch in patients with traumatic tympanic membrane perforation (TTMP). METHODS: The closure rate, otorrhea rate, and closure time in all patients and the closure time in successful patients were compared between the paper patch and silk patch groups. RESULTS: Demographic data (gender, site, age, traumatic duration, preoperative air-bone gap, and perforation size and location) were not significantly different between the two groups. The closure rate and otorrhea rate were not significantly different between the two groups. However, the closure time was different between the two groups (closure time of all patients, P=0.031; closure time of successful patients, P=0.037). CONCLUSION: The silk patch which has transparent, elastic, adhesive, and hyper-keratinizing properties results in a more efficient closure time than the paper patch in the treatment of TTMPpatients. We therefore believe that the silk patch should be recommended for the treatment of acute tympanic membrane perforation.
Authors: Jang Ho Kim; Seong Jun Choi; Jung-Sub Park; Ki Taek Lim; Pill-Hoon Choung; Seung Won Kim; Jong Bin Lee; Jong Hoon Chung; Yun-Hoon Choung Journal: Tissue Eng Part A Date: 2010-01 Impact factor: 3.845
Authors: Bing Mei Teh; Robert J Marano; Yi Shen; Peter L Friedland; Rodney J Dilley; Marcus D Atlas Journal: Tissue Eng Part B Rev Date: 2012-11-29 Impact factor: 6.389
Authors: Gregory H Altman; Frank Diaz; Caroline Jakuba; Tara Calabro; Rebecca L Horan; Jingsong Chen; Helen Lu; John Richmond; David L Kaplan Journal: Biomaterials Date: 2003-02 Impact factor: 12.479
Authors: Yi Shen; Sharon Leanne Redmond; Bing Mei Teh; Sheng Yan; Yan Wang; Lin Zhou; Charley A Budgeon; Robert Henry Eikelboom; Marcus David Atlas; Rodney James Dilley; Minghao Zheng; Robert Jeffery Marano Journal: Tissue Eng Part A Date: 2012-12-10 Impact factor: 3.845
Authors: Lorenz Meinel; Sandra Hofmann; Vassilis Karageorgiou; Carl Kirker-Head; John McCool; Gloria Gronowicz; Ludwig Zichner; Robert Langer; Gordana Vunjak-Novakovic; David L Kaplan Journal: Biomaterials Date: 2005-01 Impact factor: 12.479
Authors: Ok Joo Lee; Jung Min Lee; Ji Heui Kim; Jin Kim; HaeYong Kweon; You Young Jo; Chan Hum Park Journal: J Biomed Mater Res A Date: 2012-05-12 Impact factor: 4.396