Jin Du1, Jichang Han1, Xiandong Li1, Yajun Zhang1, Hongbing Li1, Shujuan Yang2. 1. Department of Respiratory Medicine, Huaihe Hospital of Henan University Kaifeng, China. 2. Department of Health and Social Behavior, West China School of Public Health, Sichuan University Chengdu, China.
Abstract
UNLABELLED: We conduct a case-control study to explore the possible association between IL-17 gene polymorphisms and development of TB. METHODS: The study population comprised 428 TB subjects and 428 control subjects between January 2013 and June 2014. Genotyping analyses of IL-17A rs2275913 and rs3748067 and IL-17F rs763780 and rs9382084 were analyzed using polymerase chain reaction-restriction fragment length of polymorphism (PCR-RFLP). RESULTS: The TB cases were more likely to have a habit of smoking when comparing with controls. By conditional logistic regression analysis, individuals carrying CC genotype of rs763780 were more likely to have a significantly increased risk of TB when compared with TT genotype. The OR (95% CI) for CC genotype of rs763780 was 2.98 (1.58-5.92). CONCLUSION: In conclusion, we suggest that rs763780 play a critical role in the etiology of TB. These findings could be helpful in identifying individuals at increased risk for developing TB.
UNLABELLED: We conduct a case-control study to explore the possible association between IL-17 gene polymorphisms and development of TB. METHODS: The study population comprised 428 TB subjects and 428 control subjects between January 2013 and June 2014. Genotyping analyses of IL-17Ars2275913 and rs3748067 and IL-17Frs763780 and rs9382084 were analyzed using polymerase chain reaction-restriction fragment length of polymorphism (PCR-RFLP). RESULTS: The TB cases were more likely to have a habit of smoking when comparing with controls. By conditional logistic regression analysis, individuals carrying CC genotype of rs763780 were more likely to have a significantly increased risk of TB when compared with TT genotype. The OR (95% CI) for CC genotype of rs763780 was 2.98 (1.58-5.92). CONCLUSION: In conclusion, we suggest that rs763780 play a critical role in the etiology of TB. These findings could be helpful in identifying individuals at increased risk for developing TB.
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