| Literature DB >> 26045801 |
Yi Cheng1, Jinjing Zhang2, Liancheng Deng3, Noah R Johnson4, Xichong Yu2, Ning Zhang5, Tianzheng Lou5, Yi Zhang2, Xiaojie Wei6, Zaifeng Chen6, Songbin He7, Xiaokun Li2, Jian Xiao2.
Abstract
Stem cell transplantation may provide an alternative therapy to promote functional recovery after various neurological disorders including cerebral infarct. Due to the minimal immunogenicity and neuronal differentiation potential of neural stem cells (NSCs), we tested whether intravenous administration of mice-derived C17.2 NSCs could improve neurological function deficit and cerebral infarction volume after ischemic stroke in rats. Additionally, we evaluated the survival, migration, proliferation, and differentiation capacity of transplanted NSCs in the rat brain. Intravenous infusion of NSCs after middle cerebral artery occlusion (MCAO) showed better performance in neurobiological severity scores after MCAO compared to control. However, the volume of cerebral infarction was not different at 7 days after MCAO compared with control. Transplanted NSCs were detected in the ischemic region but not in the contralateral hemisphere. NSCs differentiated into neurons or astrocytes after MCAO. These data suggest that intravenously transplanted NSCs can migrate, proliferate, and differentiate into neurons and astrocytes in the rat brain with focal ischemia and improve functional recovery.Entities:
Keywords: Ischemic stroke; cell transplantation; intravenous administration; neural stem cells
Mesh：
Year: 2015 PMID： 26045801 PMCID： PMC4440110
Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625