Literature DB >> 29916013

Stem cells technology: a powerful tool behind new brain treatments.

Lucienne N Duru1, Zhenzhen Quan1, Talal Jamil Qazi1, Hong Qing2,3.   

Abstract

Stem cell research has recently become a hot research topic in biomedical research due to the foreseen unlimited potential of stem cells in tissue engineering and regenerative medicine. For many years, medicine has been facing intense challenges, such as an insufficient number of organ donations that is preventing clinicians to fulfill the increasing needs. To try and overcome this regrettable matter, research has been aiming at developing strategies to facilitate the in vitro culture and study of stem cells as a tool for tissue regeneration. Meanwhile, new developments in the microfluidics technology brought forward emerging cell culture applications that are currently allowing for a better chemical and physical control of cellular microenvironment. This review presents the latest developments in stem cell research that brought new therapies to the clinics and how the convergence of the microfluidics technology with stem cell research can have positive outcomes on the fields of regenerative medicine and high-throughput screening. These advances will bring new translational solutions for drug discovery and will upgrade in vitro cell culture to a new level of accuracy and performance. We hope this review will provide new insights into the understanding of new brain treatments from the perspective of stem cell technology especially regarding regenerative medicine and tissue engineering.

Keywords:  Brain injuries; High-throughput screening; Lab-on-a-chip; Neurodegenerative diseases; Regenerative medicine; Stem cells

Mesh:

Year:  2018        PMID: 29916013     DOI: 10.1007/s13346-018-0548-y

Source DB:  PubMed          Journal:  Drug Deliv Transl Res        ISSN: 2190-393X            Impact factor:   4.617


  283 in total

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2.  A small molecule primes embryonic stem cells for differentiation.

Authors:  Shoutian Zhu; Heiko Wurdak; Jian Wang; Costas A Lyssiotis; Eric C Peters; Charles Y Cho; Xu Wu; Peter G Schultz
Journal:  Cell Stem Cell       Date:  2009-05-08       Impact factor: 24.633

3.  High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells.

Authors:  Sabrina C Desbordes; Dimitris G Placantonakis; Anthony Ciro; Nicholas D Socci; Gabsang Lee; Hakim Djaballah; Lorenz Studer
Journal:  Cell Stem Cell       Date:  2008-06-05       Impact factor: 24.633

4.  Engineered neural tissue for peripheral nerve repair.

Authors:  Melanie Georgiou; Stephen C J Bunting; Heather A Davies; Alison J Loughlin; Jonathan P Golding; James B Phillips
Journal:  Biomaterials       Date:  2013-07-05       Impact factor: 12.479

Review 5.  Concise review: adult mesenchymal stem cells, adult neural crest stem cells, and therapy of neurological pathologies: a state of play.

Authors:  Virginie Neirinckx; Cécile Coste; Bernard Rogister; Sabine Wislet-Gendebien
Journal:  Stem Cells Transl Med       Date:  2013-03-13       Impact factor: 6.940

6.  PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper.

Authors:  Asad A Aboud; Andrew M Tidball; Kevin K Kumar; M Diana Neely; Bingying Han; Kevin C Ess; Charles C Hong; Keith M Erikson; Peter Hedera; Aaron B Bowman
Journal:  Neurobiol Dis       Date:  2014-10-12       Impact factor: 5.996

7.  A neuron-benign microfluidic gradient generator for studying the response of mammalian neurons towards axon guidance factors.

Authors:  Nirveek Bhattacharjee; Nianzhen Li; Thomas M Keenan; Albert Folch
Journal:  Integr Biol (Camb)       Date:  2010-10-19       Impact factor: 2.192

8.  Development of a human induced pluripotent stem cell (iPSC) line from a Parkinson's disease patient carrying the N551K variant in LRRK2 gene.

Authors:  Dongrui Ma; Ebonne Yulin Ng; Li Zeng; Christina Ying Yan Lim; Yi Zhao; Eng King Tan
Journal:  Stem Cell Res       Date:  2016-12-08       Impact factor: 2.020

9.  Surface-Functionalized Silk Fibroin Films as a Platform To Guide Neuron-like Differentiation of Human Mesenchymal Stem Cells.

Authors:  Shivaprasad Manchineella; Greeshma Thrivikraman; Bikramjit Basu; T Govindaraju
Journal:  ACS Appl Mater Interfaces       Date:  2016-08-23       Impact factor: 9.229

10.  Neural stem cells secrete factors facilitating brain regeneration upon constitutive Raf-Erk activation.

Authors:  Yong-Hee Rhee; Sang-Hoon Yi; Joo Yeon Kim; Mi-Yoon Chang; A-Young Jo; Jinyoung Kim; Chang-Hwan Park; Je-Yoel Cho; Young-Jin Choi; Woong Sun; Sang-Hun Lee
Journal:  Sci Rep       Date:  2016-08-24       Impact factor: 4.379

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  1 in total

Review 1.  The potential of induced pluripotent stem cells for discriminating neurodevelopmental disorders.

Authors:  Ricarda Stock; Pauline Jeckel; Udo Kraushaar; Richard Wüst; Andreas Fallgatter; Hansjürgen Volkmer
Journal:  Stem Cells Transl Med       Date:  2020-08-31       Impact factor: 6.940

  1 in total

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