Saleh Rachidi1,2, Kristin Wallace2,3, John M Wrangle1,4, Terry A Day2,5, Anthony J Alberg2,3, Zihai Li1,2,4. 1. Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina. 2. Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina. 3. Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina. 4. Division of Hematology and Oncology-Department of Internal Medicine, Medical University of South Carolina, Charleston, South Carolina. 5. Head and Neck Tumor Center, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.
Abstract
BACKGROUND: Current prognostic criteria are insufficient in predicting outcomes in head and neck cancer, necessitating new, readily available biomarkers. METHODS: Pretreatment neutrophil and lymphocyte counts and their ratio (NLR) were retrospectively investigated for correlation with overall survival while controlling for demographic and clinical confounders. RESULTS: Patients in the highest tertile of neutrophil counts and those in the lowest tertile of lymphocytes experienced shorter survival than the rest of the population. Patients in the highest tertile of the NLR were at a higher risk compared with those in the lowest tertile after multivariate analysis (hazard ratio [HR] = 2.39; p = .0001). Additionally, NLR was lower in patients with human papillomavirus (HPV)-positive tumors compared to HPV-negative tumors and predicted survival in both tumor types. CONCLUSION: Neutrophil and lymphocyte counts are strong biomarkers with opposing prognostic significance and the NLR is a robust predictor of overall survival in oral, pharyngeal, and laryngeal squamous cell carcinomas.
BACKGROUND: Current prognostic criteria are insufficient in predicting outcomes in head and neck cancer, necessitating new, readily available biomarkers. METHODS: Pretreatment neutrophil and lymphocyte counts and their ratio (NLR) were retrospectively investigated for correlation with overall survival while controlling for demographic and clinical confounders. RESULTS:Patients in the highest tertile of neutrophil counts and those in the lowest tertile of lymphocytes experienced shorter survival than the rest of the population. Patients in the highest tertile of the NLR were at a higher risk compared with those in the lowest tertile after multivariate analysis (hazard ratio [HR] = 2.39; p = .0001). Additionally, NLR was lower in patients with humanpapillomavirus (HPV)-positive tumors compared to HPV-negative tumors and predicted survival in both tumor types. CONCLUSION: Neutrophil and lymphocyte counts are strong biomarkers with opposing prognostic significance and the NLR is a robust predictor of overall survival in oral, pharyngeal, and laryngeal squamous cell carcinomas.
Authors: Rachel F Gabitass; Nicola E Annels; Deborah D Stocken; Hardev A Pandha; Gary W Middleton Journal: Cancer Immunol Immunother Date: 2011-06-05 Impact factor: 6.968
Authors: Jacques Bernier; Jay S Cooper; T F Pajak; M van Glabbeke; J Bourhis; Arlene Forastiere; Esat Mahmut Ozsahin; John R Jacobs; J Jassem; Kie-Kian Ang; J L Lefèbvre Journal: Head Neck Date: 2005-10 Impact factor: 3.147
Authors: Eric Tran; Simon Turcotte; Alena Gros; Paul F Robbins; Yong-Chen Lu; Mark E Dudley; John R Wunderlich; Robert P Somerville; Katherine Hogan; Christian S Hinrichs; Maria R Parkhurst; James C Yang; Steven A Rosenberg Journal: Science Date: 2014-05-09 Impact factor: 47.728
Authors: Tyler J Curiel; George Coukos; Linhua Zou; Xavier Alvarez; Pui Cheng; Peter Mottram; Melina Evdemon-Hogan; Jose R Conejo-Garcia; Lin Zhang; Matthew Burow; Yun Zhu; Shuang Wei; Ilona Kryczek; Ben Daniel; Alan Gordon; Leann Myers; Andrew Lackner; Mary L Disis; Keith L Knutson; Lieping Chen; Weiping Zou Journal: Nat Med Date: 2004-08-22 Impact factor: 53.440
Authors: Kristin Wallace; Hong Li; J Grant Brazeal; David N Lewin; Shaoli Sun; Aissatou Ba; Chrystal M Paulos; Saleh Rachidi; Zihai Li; Alexander V Alekseyenko Journal: Cancer Epidemiol Date: 2020-06-07 Impact factor: 2.984
Authors: Martin Grimm; Johan Rieth; Sebastian Hoefert; Michael Krimmel; Sven Rieth; Peter Teriete; Susanne Kluba; Thorsten Biegner; Adelheid Munz; Siegmar Reinert Journal: Eur Arch Otorhinolaryngol Date: 2016-02-29 Impact factor: 2.503
Authors: Srikant Ambatipudi; Ryan Langdon; Rebecca C Richmond; Matthew Suderman; Devin C Koestler; Karl T Kelsey; Nabila Kazmi; Christopher Penfold; Karen M Ho; Wendy McArdle; Susan M Ring; Miranda Pring; Tim Waterboer; Michael Pawlita; Tom R Gaunt; George Davey Smith; Steve Thomas; Andy R Ness; Caroline L Relton Journal: Oral Oncol Date: 2018-09-05 Impact factor: 5.337
Authors: Alexander J Lin; Margery Gang; Yuan James Rao; Jian Campian; Mackenzie Daly; Hiram Gay; Peter Oppelt; Ryan S Jackson; Jason Rich; Randal Paniello; Jose Zevallos; Dennis Hallahan; Douglas Adkins; Wade Thorstad Journal: JAMA Otolaryngol Head Neck Surg Date: 2019-05-01 Impact factor: 6.223