| Literature DB >> 26036184 |
Teresinha de Jesus Brabo Ferreira Palha1, Elzemar Martins Ribeiro Rodrigues1, Giovanna Chaves Cavalcante2, Andrea Marrero3, Ilíada Rainha de Souza3, Clineu Julien Seki Uehara4, Carlos Henrique Ares Silveira da Motta5, Daniela Koshikene6, Dayse Aparecida da Silva7, Elizeu Fagundes de Carvalho7, Gustavo Chemale8, Jorge M Freitas8, Lídia Alexandre8, Renato T F Paranaiba8, Mirella Perruccio Soler9, Sidney Santos10.
Abstract
The aim of this study was to estimate the diversity of 30 insertion/deletion (INDEL) markers (Investigator(®) DIPplex kit) in a sample of 519 individuals from six Brazilian states and to evaluate their applicability in forensic genetics. All INDEL markers were found to be highly polymorphic in the Brazilian population and were in Hardy-Weinberg equilibrium. To determine their forensic suitability in the Brazilian population, the markers were evaluated for discrimination power, match probability and exclusion power. The combined discrimination power (CDP), combined match power (CMP) and combined power of exclusion (CPE) were higher than 0.999999, 3.4 × 10(-13) and 0.9973, respectively. Further comparison of 29 worldwide populations revealed significant genetic differences between continental populations and a closer relationship between the Brazilian and European populations.Keywords: Biallelic; Brazilian population; INDEL; Insertion–deletion polymorphisms; Investigator DIPplex(®) kit
Mesh：
Year: 2015 PMID： 26036184 DOI： 10.1016/j.fsigen.2015.03.015
Source DB: PubMed Journal: Forensic Sci Int Genet ISSN： 1872-4973 Impact factor: 4.882