| Literature DB >> 26033727 |
Ya-Han Chih1, Yen-Shan Lin1, Bak-Sau Yip2, Hsiu-Ju Wei1, Hung-Lun Chu1, Hui-Yuan Yu1, Hsi-Tsung Cheng1, Yu-Ting Chou3, Jya-Wei Cheng3.
Abstract
Release of lipopolysaccharide (LPS) (endotoxin) from bacteria into the bloodstream may cause serious unwanted stimulation of the host immune system. Some but not all antimicrobial peptides can neutralize LPS-stimulated proinflammatory responses. Salt resistance and serum stability of short antimicrobial peptides can be boosted by adding β-naphthylalanine to their termini. Herein, significant antiendotoxin effects were observed in vitro and in vivo with the β-naphthylalanine end-tagged variants of the short antimicrobial peptides S1 and KWWK.Entities:
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Year: 2015 PMID: 26033727 PMCID: PMC4505259 DOI: 10.1128/AAC.00519-15
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191