Literature DB >> 26033727

Ultrashort Antimicrobial Peptides with Antiendotoxin Properties.

Ya-Han Chih1, Yen-Shan Lin1, Bak-Sau Yip2, Hsiu-Ju Wei1, Hung-Lun Chu1, Hui-Yuan Yu1, Hsi-Tsung Cheng1, Yu-Ting Chou3, Jya-Wei Cheng3.   

Abstract

Release of lipopolysaccharide (LPS) (endotoxin) from bacteria into the bloodstream may cause serious unwanted stimulation of the host immune system. Some but not all antimicrobial peptides can neutralize LPS-stimulated proinflammatory responses. Salt resistance and serum stability of short antimicrobial peptides can be boosted by adding β-naphthylalanine to their termini. Herein, significant antiendotoxin effects were observed in vitro and in vivo with the β-naphthylalanine end-tagged variants of the short antimicrobial peptides S1 and KWWK.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID: 26033727      PMCID: PMC4505259          DOI: 10.1128/AAC.00519-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  37 in total

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6.  Boosting salt resistance of short antimicrobial peptides.

Authors:  Hung-Lun Chu; Hui-Yuan Yu; Bak-Sau Yip; Ya-Han Chih; Chong-Wen Liang; Hsi-Tsung Cheng; Jya-Wei Cheng
Journal:  Antimicrob Agents Chemother       Date:  2013-05-28       Impact factor: 5.191

7.  Parameters involved in antimicrobial and endotoxin detoxification activities of antimicrobial peptides.

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10.  The two peptide lantibiotic lacticin 3147 acts synergistically with polymyxin to inhibit Gram negative bacteria.

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1.  High Level Expression and Purification of Cecropin-like Antimicrobial Peptides in Escherichia coli.

Authors:  Chih-Lung Wu; Ya-Han Chih; Hsin-Ying Hsieh; Kuang-Li Peng; Yi-Zong Lee; Bak-Sau Yip; Shih-Che Sue; Jya-Wei Cheng
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2.  Antimicrobial activity and stability of the D-amino acid substituted derivatives of antimicrobial peptide polybia-MPI.

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3.  Antimicrobial Peptides Display Strong Synergy with Vancomycin Against Vancomycin-Resistant E. faecium, S. aureus, and Wild-Type E. coli.

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Review 4.  Recent Advances in Anti-virulence Therapeutic Strategies With a Focus on Dismantling Bacterial Membrane Microdomains, Toxin Neutralization, Quorum-Sensing Interference and Biofilm Inhibition.

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Journal:  Front Cell Infect Microbiol       Date:  2019-04-02       Impact factor: 5.293

5.  Blood Compatibility-An Important but Often Forgotten Aspect of the Characterization of Antimicrobial Peptides for Clinical Application.

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6.  Interactive association of lipopolysaccharide and free fatty acid with the prevalence of type 2 diabetes: A community-based cross-sectional study.

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7.  Antimicrobial Peptides with Enhanced Salt Resistance and Antiendotoxin Properties.

Authors:  Hung-Lun Chu; Ya-Han Chih; Kuang-Li Peng; Chih-Lung Wu; Hui-Yuan Yu; Doris Cheng; Yu-Ting Chou; Jya-Wei Cheng
Journal:  Int J Mol Sci       Date:  2020-09-16       Impact factor: 5.923

8.  A Novel Antimicrobial Peptide Derived from Bony Fish IFN1 Exerts Potent Antimicrobial and Anti-Inflammatory Activity in Mammals.

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Review 9.  Synergy by Perturbing the Gram-Negative Outer Membrane: Opening the Door for Gram-Positive Specific Antibiotics.

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  9 in total

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