Heather G Allore1, Yilei Zhan2, Mary Tinetti3, Mark Trentalange4, Gail McAvay4. 1. Section of Geriatrics, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT; Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, CT. Electronic address: Heather.Allore@Yale.edu. 2. Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, CT. 3. Section of Geriatrics, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT; Department of Chronic Disease, Yale School of Public Health, Yale University, New Haven, CT. 4. Section of Geriatrics, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT.
Abstract
PURPOSE: The objective is to modify the longitudinal extension of the average attributable fraction (LE-AAF) for recurrent outcomes with time-varying exposures and control for covariates. METHODS: We included Medicare Current Beneficiary Survey participants with two or more chronic conditions enrolled from 2005 to 2009 with follow-up through 2011. Nine time-varying medications indicated for nine time-varying common chronic conditions and 14 of 18 forward-selected participant characteristics were used as control variables in the generalized estimating equations step of the LE-AAF to estimate associations with the recurrent universal health outcome self-rated health (SRH). Modifications of the LE-AAF were made to accommodate these indicated medication-condition interactions and covariates. Variability was empirically estimated by bias-corrected and accelerated bootstrapping. RESULTS: In the adjusted LE-AAF, thiazide, warfarin, and clopidogrel had significant contributions of 1.2%, 0.4%, 0.2%, respectively, to low (poor or fair) SRH; whereas there were no significant contributions of the other medications to SRH. Hyperlipidemia significantly contributed 4.6% to high SRH. All the other conditions except atrial fibrillation contributed significantly to low SRH. CONCLUSIONS: Our modifications to the LE-AAF method apply to a recurrent binary outcome with time-varying factors accounting for covariates.
PURPOSE: The objective is to modify the longitudinal extension of the average attributable fraction (LE-AAF) for recurrent outcomes with time-varying exposures and control for covariates. METHODS: We included Medicare Current Beneficiary Survey participants with two or more chronic conditions enrolled from 2005 to 2009 with follow-up through 2011. Nine time-varying medications indicated for nine time-varying common chronic conditions and 14 of 18 forward-selected participant characteristics were used as control variables in the generalized estimating equations step of the LE-AAF to estimate associations with the recurrent universal health outcome self-rated health (SRH). Modifications of the LE-AAF were made to accommodate these indicated medication-condition interactions and covariates. Variability was empirically estimated by bias-corrected and accelerated bootstrapping. RESULTS: In the adjusted LE-AAF, thiazide, warfarin, and clopidogrel had significant contributions of 1.2%, 0.4%, 0.2%, respectively, to low (poor or fair) SRH; whereas there were no significant contributions of the other medications to SRH. Hyperlipidemia significantly contributed 4.6% to high SRH. All the other conditions except atrial fibrillation contributed significantly to low SRH. CONCLUSIONS: Our modifications to the LE-AAF method apply to a recurrent binary outcome with time-varying factors accounting for covariates.
Authors: Mary E Tinetti; Gail J McAvay; Terrence E Murphy; Cary P Gross; Haiqun Lin; Heather G Allore Journal: J Am Geriatr Soc Date: 2012-06-26 Impact factor: 5.562
Authors: Mary E Tinetti; Gail McAvay; Sandy S Chang; Yuming Ning; Anne B Newman; Annette Fitzpatrick; Terri R Fried; Tamara B Harris; Michael C Nevitt; Suzanne Satterfield; Kristine Yaffe; Peter Peduzzi Journal: J Am Geriatr Soc Date: 2011-08-24 Impact factor: 5.562
Authors: Mary E Tinetti; Ling Han; David S H Lee; Gail J McAvay; Peter Peduzzi; Cary P Gross; Bingqing Zhou; Haiqun Lin Journal: JAMA Intern Med Date: 2014-04 Impact factor: 21.873
Authors: Haiqun Lin; Heather G Allore; Gail McAvay; Mary E Tinetti; Thomas M Gill; Cary P Gross; Terrence E Murphy Journal: Am J Public Health Date: 2012-04-19 Impact factor: 9.308
Authors: Mark A Espeland; Eileen M Crimmins; Brandon R Grossardt; Jill P Crandall; Jonathan A L Gelfond; Tamara B Harris; Stephen B Kritchevsky; JoAnn E Manson; Jennifer G Robinson; Walter A Rocca; Marinella Temprosa; Fridtjof Thomas; Robert Wallace; Nir Barzilai Journal: J Gerontol A Biol Sci Med Sci Date: 2017-03-01 Impact factor: 6.053
Authors: Gail McAvay; Heather G Allore; Andrew B Cohen; Danijela Gnjidic; Terrence E Murphy; Mary E Tinetti Journal: J Am Geriatr Soc Date: 2017-09-14 Impact factor: 5.562