OBJECTIVES: We decomposed the total effect of coexisting diseases on a timed occurrence of an adverse outcome into additive effects from individual diseases. METHODS: In a cohort of older adults enrolled in the Precipitating Events Project in New Haven County, Connecticut, we assessed a longitudinal extension of the average attributable fraction method (LE-AAF) to estimate the additive and order-free contributions of multiple diseases to the timed occurrence of a health outcome, with right censoring, which may be useful when relationships among diseases are complex. We partitioned the contribution to death into additive LE-AAFs for multiple diseases. RESULTS: The onset of heart failure and acute episodes of pneumonia during follow-up contributed the most to death, with the overall LE-AAFs equal to 13.0% and 12.1%, respectively. The contribution of preexisting diseases decreased over the years, with a trend of increasing contribution from new onset of diseases. CONCLUSIONS: LE-AAF can be useful for determining the additive and order-free contribution of individual time-varying diseases to a time-to-event outcome.
OBJECTIVES: We decomposed the total effect of coexisting diseases on a timed occurrence of an adverse outcome into additive effects from individual diseases. METHODS: In a cohort of older adults enrolled in the Precipitating Events Project in New Haven County, Connecticut, we assessed a longitudinal extension of the average attributable fraction method (LE-AAF) to estimate the additive and order-free contributions of multiple diseases to the timed occurrence of a health outcome, with right censoring, which may be useful when relationships among diseases are complex. We partitioned the contribution to death into additive LE-AAFs for multiple diseases. RESULTS: The onset of heart failure and acute episodes of pneumonia during follow-up contributed the most to death, with the overall LE-AAFs equal to 13.0% and 12.1%, respectively. The contribution of preexisting diseases decreased over the years, with a trend of increasing contribution from new onset of diseases. CONCLUSIONS: LE-AAF can be useful for determining the additive and order-free contribution of individual time-varying diseases to a time-to-event outcome.
Authors: Gabriela Vazquez-Benitez; Jay R Desai; Stanley Xu; Glenn K Goodrich; Emily B Schroeder; Gregory A Nichols; Jodi Segal; Melissa G Butler; Andrew J Karter; John F Steiner; Katherine M Newton; Leo S Morales; Ram D Pathak; Abraham Thomas; Kristi Reynolds; H Lester Kirchner; Beth Waitzfelder; Jennifer Elston Lafata; Renuka Adibhatla; Zhiyuan Xu; Patrick J O'Connor Journal: Diabetes Care Date: 2015-02-20 Impact factor: 19.112
Authors: Heather G Allore; Yilei Zhan; Andrew B Cohen; Mary E Tinetti; Mark Trentalange; Gail McAvay Journal: J Gerontol A Biol Sci Med Sci Date: 2016-01-08 Impact factor: 6.053
Authors: Manisha Juthani-Mehta; Nathalie De Rekeneire; Heather Allore; Shu Chen; John R O'Leary; Douglas C Bauer; Tamara B Harris; Anne B Newman; Sachin Yende; Robert J Weyant; Stephen Kritchevsky; Vincent Quagliarello Journal: J Am Geriatr Soc Date: 2013-06-17 Impact factor: 5.562
Authors: Pablo F Belaunzarán-Zamudio; Yanink N Caro-Vega; Bryan E Shepherd; Peter F Rebeiro; Brenda E Crabtree-Ramírez; Claudia P Cortes; Beatriz Grinsztejn; Eduardo Gotuzzo; Fernando Mejia; Denis Padgett; Jean W Pape; Vanessa Rouzier; Valdilea Veloso; Sandra Wagner Cardoso; Catherine C McGowan; Juan G Sierra-Madero Journal: Am J Epidemiol Date: 2020-06-01 Impact factor: 4.897
Authors: Renata T C Yokota; Nicolas Berger; Wilma J Nusselder; Jean-Marie Robine; Jean Tafforeau; Patrick Deboosere; Herman Van Oyen Journal: BMC Public Health Date: 2015-03-07 Impact factor: 3.295
Authors: Renata T C Yokota; Johan Van der Heyden; Stefaan Demarest; Jean Tafforeau; Willma J Nusselder; Patrick Deboosere; Herman Van Oyen Journal: Arch Public Health Date: 2015-08-03
Authors: Peter Tanuseputro; Richard Perez; Laura Rosella; Kumanan Wilson; Carol Bennett; Meltem Tuna; Deirdre Hennessy; Heather Manson; Douglas Manuel Journal: Popul Health Metr Date: 2015-02-19
Authors: Christiane Muth; Sebastian Harder; Lorenz Uhlmann; Justine Rochon; Birgit Fullerton; Corina Güthlin; Antje Erler; Martin Beyer; Marjan van den Akker; Rafael Perera; André Knottnerus; Jose M Valderas; Ferdinand M Gerlach; Walter E Haefeli Journal: BMJ Open Date: 2016-07-25 Impact factor: 2.692