Literature DB >> 26030445

Functional differentiation of human pluripotent stem cells on a chip.

Giovanni G Giobbe1, Federica Michielin1, Camilla Luni1, Stefano Giulitti1, Sebastian Martewicz1, Sirio Dupont2, Annarosa Floreani3, Nicola Elvassore1.   

Abstract

Microengineering human "organs-on-chips" remains an open challenge. Here, we describe a robust microfluidics-based approach for the differentiation of human pluripotent stem cells directly on a chip. Extrinsic signal modulation, achieved through optimal frequency of medium delivery, can be used as a parameter for improved germ layer specification and cell differentiation. Human cardiomyocytes and hepatocytes derived on chips showed functional phenotypes and responses to temporally defined drug treatments.

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Year:  2015        PMID： 26030445     DOI： 10.1038/nmeth.3411

Source DB:  PubMed          Journal:  Nat Methods        ISSN： 1548-7091            Impact factor:   28.547


  36 in total

Review 1.  Progress, obstacles, and limitations in the use of stem cells in organ-on-a-chip models.

Authors:  Alexa Wnorowski; Huaxiao Yang; Joseph C Wu
Journal:  Adv Drug Deliv Rev       Date:  2018-06-06       Impact factor: 15.470

2.  Patient-derived induced pluripotent stem cells in cancer research and precision oncology.

Authors:  Eirini P Papapetrou
Journal:  Nat Med       Date:  2016-12-06       Impact factor: 53.440

Review 3.  Biotechnology Challenges to In Vitro Maturation of Hepatic Stem Cells.

Authors:  Chen Chen; Alejandro Soto-Gutierrez; Pedro M Baptista; Bart Spee
Journal:  Gastroenterology       Date:  2018-02-08       Impact factor: 22.682

4.  High-efficiency cellular reprogramming with microfluidics.

Authors:  Camilla Luni; Stefano Giulitti; Elena Serena; Luca Ferrari; Alessandro Zambon; Onelia Gagliano; Giovanni G Giobbe; Federica Michielin; Sebastian Knöbel; Andreas Bosio; Nicola Elvassore
Journal:  Nat Methods       Date:  2016-04-18       Impact factor: 28.547

5.  Generation of human muscle fibers and satellite-like cells from human pluripotent stem cells in vitro.

Authors:  Jérome Chal; Ziad Al Tanoury; Marie Hestin; Bénédicte Gobert; Suvi Aivio; Aurore Hick; Thomas Cherrier; Alexander P Nesmith; Kevin K Parker; Olivier Pourquié
Journal:  Nat Protoc       Date:  2016-09-01       Impact factor: 13.491

Review 6.  Li-Fraumeni Syndrome Disease Model: A Platform to Develop Precision Cancer Therapy Targeting Oncogenic p53.

Authors:  Ruoji Zhou; An Xu; Julian Gingold; Louise C Strong; Ruiying Zhao; Dung-Fang Lee
Journal:  Trends Pharmacol Sci       Date:  2017-08-14       Impact factor: 14.819

7.  In situ characterization of the mTORC1 during adipogenesis of human adult stem cells on chip.

Authors:  Xuanye Wu; Nils Schneider; Alina Platen; Indranil Mitra; Matthias Blazek; Roland Zengerle; Roland Schüle; Matthias Meier
Journal:  Proc Natl Acad Sci U S A       Date:  2016-07-05       Impact factor: 11.205

Review 8.  Engineered Microsystems for Spheroid and Organoid Studies.

Authors:  Sung-Min Kang; Daehan Kim; Ji-Hoon Lee; Shuichi Takayama; Joong Yull Park
Journal:  Adv Healthc Mater       Date:  2020-11-13       Impact factor: 9.933

9.  The Microfluidic Environment Reveals a Hidden Role of Self-Organizing Extracellular Matrix in Hepatic Commitment and Organoid Formation of hiPSCs.

Authors:  Federica Michielin; Giovanni G Giobbe; Camilla Luni; Qianjiang Hu; Ida Maroni; Michael R Orford; Anna Manfredi; Lucio Di Filippo; Anna L David; Davide Cacchiarelli; Paolo De Coppi; Simon Eaton; Nicola Elvassore
Journal:  Cell Rep       Date:  2020-12-01       Impact factor: 9.423

Review 10.  Bioengineering platforms for cell therapeutics derived from pluripotent and direct reprogramming.

Authors:  Yoonhee Jin; Seung-Woo Cho
Journal:  APL Bioeng       Date:  2021-07-06
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