Lawrence D Hayes1,2, Nicholas Sculthorpe2, Peter Herbert3, Julien S Baker2, Roberto Spagna4, Fergal M Grace2. 1. a School of Human Sciences, London Metropolitan University , London , UK . 2. b Institute of Clinical Exercise and Health Science, University of the West of Scotland , Hamilton , UK . 3. c School of Sport, Health and Outdoor Education, Trinity Saint David, University of Wales , Carmatrthen , UK , and. 4. d Department of Clinical Biochemistry , Royal Glamorgan Hospital , Pontyclun , Mid Glamorgan , UK.
Abstract
INTRODUCTION: Advancing age is associated with a gradual decline in circulating androgens, and the putative role of exercise training on systemic androgens remains to be adequately defined. METHODS: The present investigation examined the impact of 6 weeks of supervised exercise training on resting levels of systemic hormones in a cohort of lifelong sedentary men [SED (n = 28), 62.5 ± 5.3 years], compared with a positive control group of age-matched lifelong exercisers [LE (n = 20), 60.4 ± 4.7 years, >30 years training history]. Blood hormones were sampled pre- and post-intervention from an antecubital forearm vein and analysed using electrochemiluminescent immunoassay. Cardiorespiratory fitness ([Formula: see text]) was determined via indirect calorimetry during an incremental cycle test to volitional exhaustion. RESULTS: Analysis of variance (ANOVA) revealed a lack of significant change in any parameter amongst LE, whilst SED experienced a significant exercise-induced improvement in cardiorespiratory fitness and total testosterone (all p < 0.05). Concurrent increases in sex hormone-binding globulin (SHBG; p < 0.05) resulted in a lack of change to either bioavailable or calculated free testosterone (p > 0.05) amongst SED. CONCLUSIONS: Although resting levels of systemic total testosterone increased in response to 6 weeks of exercise training, increases in SHBG negated any potential relationship between calculated-free or bioavailable testosterone. These findings indicate that increases in bioavailable testosterone fraction are not required for cardiorespiratory fitness improvements in aging men.
INTRODUCTION: Advancing age is associated with a gradual decline in circulating androgens, and the putative role of exercise training on systemic androgens remains to be adequately defined. METHODS: The present investigation examined the impact of 6 weeks of supervised exercise training on resting levels of systemic hormones in a cohort of lifelong sedentary men [SED (n = 28), 62.5 ± 5.3 years], compared with a positive control group of age-matched lifelong exercisers [LE (n = 20), 60.4 ± 4.7 years, >30 years training history]. Blood hormones were sampled pre- and post-intervention from an antecubital forearm vein and analysed using electrochemiluminescent immunoassay. Cardiorespiratory fitness ([Formula: see text]) was determined via indirect calorimetry during an incremental cycle test to volitional exhaustion. RESULTS: Analysis of variance (ANOVA) revealed a lack of significant change in any parameter amongst LE, whilst SED experienced a significant exercise-induced improvement in cardiorespiratory fitness and total testosterone (all p < 0.05). Concurrent increases in sex hormone-binding globulin (SHBG; p < 0.05) resulted in a lack of change to either bioavailable or calculated free testosterone (p > 0.05) amongst SED. CONCLUSIONS: Although resting levels of systemic total testosterone increased in response to 6 weeks of exercise training, increases in SHBG negated any potential relationship between calculated-free or bioavailable testosterone. These findings indicate that increases in bioavailable testosterone fraction are not required for cardiorespiratory fitness improvements in aging men.
Entities:
Keywords:
Aging; exercise; sex hormone-binding globulin; testosterone
Authors: Maha Sellami; Wissem Dhahbi; Lawrence D Hayes; Johnny Padulo; Fatma Rhibi; Hanen Djemail; Anis Chaouachi Journal: PLoS One Date: 2017-08-11 Impact factor: 3.240
Authors: Zerbu Yasar; Bradley T Elliott; Yvoni Kyriakidou; Chiazor T Nwokoma; Ruth D Postlethwaite; Christopher J Gaffney; Susan Dewhurst; Lawrence D Hayes Journal: Eur J Appl Physiol Date: 2021-03-16 Impact factor: 3.078
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Authors: Maha Sellami; Maha Gasmi; Joshua Denham; Lawrence D Hayes; Dan Stratton; Johnny Padulo; Nicola Bragazzi Journal: Front Immunol Date: 2018-10-10 Impact factor: 7.561