| Literature DB >> 26029870 |
Zhao Ye1, Zhiqiang Li2, Yongfei Wang1, Ying Mao1, Ming Shen1, Qilin Zhang1, Shiqi Li1, Liangfu Zhou1, Xuefei Shou1, Jianhua Chen3, Zhijian Song2, Zengyi Ma1, Zhaoyun Zhang4, Yiming Li4, Hongying Ye4, Chuanxin Huang5, Tao Wang6, Wenqiang He1, Yichao Zhang1, Rong Xie1, Nidan Qiao1, Huijia Qiu1, Shan Huang6, Meng Wang2, Jiawei Shen2, Zujia Wen2, Wenjin Li2, Ke Liu2, Juan Zhou2, Lin Wang2, Jue Ji2, Yin Wang7, Hong Chen7, Haixia Cheng7, Zhifeng Shi1, Yuqian Zhu1, Daoying Geng8, Zhenwei Yao8, Weijun Tang8, Bin Lu4, Li Pan1, Yi Zhang1, Weimin Bao1, Jinsong Wu1, Kang Zheng1, Yongyong Shi9, Yao Zhao1.
Abstract
Pituitary adenoma is one of the most common intracranial neoplasms, and its genetic basis remains largely unknown. To identify genetic susceptibility loci for sporadic pituitary adenoma, we performed a three-stage genome-wide association study (GWAS) in the Han Chinese population. We first analyzed genome-wide SNP data in 771 pituitary adenoma cases and 2,788 controls and then carried forward the promising variants for replication in another 2 independent sets (2,542 cases and 3,620 controls in total). We identified three new susceptibility loci below the genome-wide significance threshold (P < 5 × 10(-8)) in the combined analyses: 10p12.31 (rs2359536, P(meta) = 2.25 × 10(-10) and rs10828088, P(meta) = 6.27 × 10(-10)), 10q21.1 (rs10763170, P(meta) = 6.88 × 10(-10)) and 13q12.13 (rs17083838, P(meta) = 1.89 × 10(-8)). This study is the first GWAS to our knowledge on sporadic pituitary adenoma, and our results provide insight into the genetic basis of this disease.Entities:
Mesh：
Year: 2015 PMID： 26029870 DOI： 10.1038/ng.3322
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330