| Literature DB >> 30571610 |
Soujanya D Yelamanchi1, Ankur Tyagi2, Varshasnata Mohanty2, Pinaki Dutta3, Márta Korbonits4, Sandip Chavan1, Jayshree Advani1,5, Anil K Madugundu1,5,6,7, Gourav Dey1,5, Keshava K Datta1, M Rajyalakshmi8, Nandini A Sahasrabuddhe1, Abhishek Chaturvedi9, Amit Kumar10, Apabrita Ayan Das11, Dhiman Ghosh12, Gajendra M Jogdand10, Haritha H Nair13, Keshav Saini14, Manoj Panchal15, Mansi Ashwinsinh Sarvaiya16, Soundappan S Mohanraj17, Nabonita Sengupta18, Priti Saxena14, Pradeep Annamalai Subramani19, Pradeep Kumar20, Rakhil Akkali21, Saraswatipura Vishwabrahmachar Reshma22, Ramachandran Sarojini Santhosh23, Sangita Rastogi24, Sudarshan Kumar25, Susanta Kumar Ghosh19, Vamshi Krishna Irlapati26, Anand Srinivasan27, Bishan Das Radotra28, Premendu P Mathur29, G William Wong30, Parthasarathy Satishchandra31, Aditi Chatterjee1, Harsha Gowda1, Anil Bhansali3, Akhilesh Pandey1,5,6,7,32,33,34,35, Susarla K Shankar36,37, Anita Mahadevan36,37, T S Keshava Prasad1,2.
Abstract
The pituitary function is regulated by a complex system involving the hypothalamus and biological networks within the pituitary. Although the hormones secreted from the pituitary have been well studied, comprehensive analyses of the pituitary proteome are limited. Pituitary proteomics is a field of postgenomic research that is crucial to understand human health and pituitary diseases. In this context, we report here a systematic proteomic profiling of human anterior pituitary gland (adenohypophysis) using high-resolution Fourier transform mass spectrometry. A total of 2164 proteins were identified in this study, of which 105 proteins were identified for the first time compared with high-throughput proteomic-based studies from human pituitary glands. In addition, we identified 480 proteins with secretory potential and 187 N-terminally acetylated proteins. These are the first region-specific data that could serve as a vital resource for further investigations on the physiological role of the human anterior pituitary glands and the proteins secreted by them. We anticipate that the identification of previously unknown proteins in the present study will accelerate biomedical research to decipher their role in functioning of the human anterior pituitary gland and associated human diseases.Entities:
Keywords: anterior pituitary; biomarkers; diagnostics; endocrinology; ophthalmology; proteomics
Mesh：
Substances：
Year: 2018 PMID： 30571610 PMCID： PMC6425986 DOI： 10.1089/omi.2018.0160
Source DB: PubMed Journal: OMICS ISSN： 1536-2310