Literature DB >> 26029740

MiR-506: A Multitasker in Suppression of the Epithelial-to-Mesenchymal Transition.

Yan Sun1, Delia Mezzanzanica2, Wei Zhang3.   

Abstract

MiRNAs emerge as important regulators of epithelial-to-mesenchymal transition (EMT). The Best known EMT regulatory miRNAs are targeting the transcriptional repressors of E-cadherin (E-cad). We identified miR-506 as a key EMT inhibitor through directly targeting the E-cad transcriptional repressor, SNAI2. Our recent studies showed that miR-506 simultaneously suppresses vimentin and N-cad. Thus, miR-506 possesses a multitasking property in the suppression of EMT and metastasis and thus may represent a promising tool in cancer therapeutics.

Entities:  

Keywords:  N-cadherin; epithelial ovarian cancer; epithelial-to-mesenchymal transition; miR-506; nanoparticle; vimentin

Year:  2014        PMID： 26029740      PMCID： PMC4447487          DOI： 10.14800/rd.447

Source DB:  PubMed          Journal:  RNA Dis        ISSN： 2375-2467


  15 in total

1.  The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells.

Authors:  E Batlle; E Sancho; C Francí; D Domínguez; M Monfar; J Baulida; A García De Herreros
Journal:  Nat Cell Biol       Date:  2000-02       Impact factor: 28.824

Review 2.  EMT: when epithelial cells decide to become mesenchymal-like cells.

Authors:  Raghu Kalluri
Journal:  J Clin Invest       Date:  2009-06       Impact factor: 14.808

3.  MiR-506 inhibits multiple targets in the epithelial-to-mesenchymal transition network and is associated with good prognosis in epithelial ovarian cancer.

Authors:  Yan Sun; Limei Hu; Hong Zheng; Marina Bagnoli; Yuhong Guo; Rajesha Rupaimoole; Cristian Rodriguez-Aguayo; Gabriel Lopez-Berestein; Ping Ji; Kexin Chen; Anil K Sood; Delia Mezzanzanica; Jinsong Liu; Baocun Sun; Wei Zhang
Journal:  J Pathol       Date:  2014-11-06       Impact factor: 7.996

4.  Epithelial-mesenchymal transition and mesenchymal-epithelial transition via regulation of ZEB-1 and ZEB-2 expression in pancreatic cancer.

Authors:  Hiroshi Kurahara; Sonshin Takao; Kosei Maemura; Yuko Mataki; Taisaku Kuwahata; Koki Maeda; Qiang Ding; Masahiko Sakoda; Satoshi Iino; Sumiya Ishigami; Shinichi Ueno; Hiroyuki Shinchi; Shoji Natsugoe
Journal:  J Surg Oncol       Date:  2011-12-27       Impact factor: 3.454

5.  Twist2 contributes to breast cancer progression by promoting an epithelial-mesenchymal transition and cancer stem-like cell self-renewal.

Authors:  X Fang; Y Cai; J Liu; Z Wang; Q Wu; Z Zhang; C J Yang; L Yuan; G Ouyang
Journal:  Oncogene       Date:  2011-05-23       Impact factor: 9.867

6.  Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer.

Authors:  Da Yang; Yan Sun; Limei Hu; Hong Zheng; Ping Ji; Chad V Pecot; Yanrui Zhao; Sheila Reynolds; Hanyin Cheng; Rajesha Rupaimoole; David Cogdell; Matti Nykter; Russell Broaddus; Cristian Rodriguez-Aguayo; Gabriel Lopez-Berestein; Jinsong Liu; Ilya Shmulevich; Anil K Sood; Kexin Chen; Wei Zhang
Journal:  Cancer Cell       Date:  2013-02-11       Impact factor: 31.743

7.  Cancer statistics, 2013.

Authors:  Rebecca Siegel; Deepa Naishadham; Ahmedin Jemal
Journal:  CA Cancer J Clin       Date:  2013-01-17       Impact factor: 508.702

8.  Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis.

Authors:  Jing Yang; Sendurai A Mani; Joana Liu Donaher; Sridhar Ramaswamy; Raphael A Itzykson; Christophe Come; Pierre Savagner; Inna Gitelman; Andrea Richardson; Robert A Weinberg
Journal:  Cell       Date:  2004-06-25       Impact factor: 41.582

Review 9.  MicroRNAs: regulators of cancer metastasis and epithelial-mesenchymal transition (EMT).

Authors:  Xiang-Ming Ding
Journal:  Chin J Cancer       Date:  2013-09-09

10.  miR-506 regulates epithelial mesenchymal transition in breast cancer cell lines.

Authors:  Himanshu Arora; Rehana Qureshi; Woong-Yang Park
Journal:  PLoS One       Date:  2013-05-22       Impact factor: 3.240
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  3 in total

Review 1.  Role of MicroRNAs in Signaling Pathways Associated with the Pathogenesis of Idiopathic Pulmonary Fibrosis: A Focus on Epithelial-Mesenchymal Transition.

Authors:  Ana Ruth Cadena-Suárez; Hilda Arely Hernández-Hernández; Noé Alvarado-Vásquez; Claudia Rangel-Escareño; Bettina Sommer; María Cristina Negrete-García
Journal:  Int J Mol Sci       Date:  2022-06-14       Impact factor: 6.208

2.  Suppression of epithelial-mesenchymal transition in hepatocellular carcinoma cells by Krüppel-like factor 4.

Authors:  Qi Li; Weifeng Song; Weiyu Wang; Shanshan Yao; Chuan Tian; Xun Cai; Liwei Wang
Journal:  Oncotarget       Date:  2016-05-17

3.  Plasma miRNA-506 as a Prognostic Biomarker for Esophageal Squamous Cell Carcinoma.

Authors:  Shu-Ping Li; Hong-Xin Su; Da Zhao; Quan-Lin Guan
Journal:  Med Sci Monit       Date:  2016-06-27
  3 in total

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