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Literature DB >> 19487817

EMT: when epithelial cells decide to become mesenchymal-like cells.

Abstract

Epithelial-mesenchymal transition (EMT) is critical for appropriate embryonic development, and this process is re-engaged in adults during wound healing, tissue regeneration, organ fibrosis, and cancer progression. Inflammation is a crucial conspirator in the emergence of EMT in adults but is absent during embryonic development. As highlighted in this Review series, EMT is now a recognized mechanism for dispersing cells in embryos, forming fibroblasts/mesenchymal cells in injured tissues, and initiating metastasis of epithelial cancer cells. Also discussed are proposals to classify EMT into three subtypes, each of which has different functional consequences.

Entities: Disease

Mesh：

Year: 2009 PMID： 19487817 PMCID： PMC2689122 DOI： 10.1172/JCI39675

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

21 in total

Review 1. Cell polarity: Versatile scaffolds keep things in place.

Authors: C Yeaman; K K Grindstaff; M D Hansen; W J Nelson
Journal: Curr Biol Date: 1999-07-15 Impact factor: 10.834

Review 2. Epithelial-mesenchymal transitions in tumour progression.

Authors: Jean Paul Thiery
Journal: Nat Rev Cancer Date: 2002-06 Impact factor: 60.716

Review 3. Epithelial morphogenesis.

Authors: B M Gumbiner
Journal: Cell Date: 1992-05-01 Impact factor: 41.582

Review 4. Fibroblasts in cancer.

Authors: Raghu Kalluri; Michael Zeisberg
Journal: Nat Rev Cancer Date: 2006-05 Impact factor: 60.716

5. Evidence for a role of epithelial mesenchymal transition during pathogenesis of fistulae in Crohn's disease.

Authors: Frauke Bataille; Christian Rohrmeier; Richard Bates; Achim Weber; Florian Rieder; Julia Brenmoehl; Ulrike Strauch; Stefan Farkas; Alois Fürst; Ferdinand Hofstädter; Jürgen Schölmerich; Hans Herfarth; Gerhard Rogler
Journal: Inflamm Bowel Dis Date: 2008-11 Impact factor: 5.325

Review 6. The basics of epithelial-mesenchymal transition.

Authors: Raghu Kalluri; Robert A Weinberg
Journal: J Clin Invest Date: 2009-06 Impact factor: 14.808

7. The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis.

Authors: Chengsen Xue; David Plieth; Christo Venkov; Carol Xu; Eric G Neilson
Journal: Cancer Res Date: 2003-06-15 Impact factor: 12.701

8. Tumor response to combination celecoxib and erlotinib therapy in non-small cell lung cancer is associated with a low baseline matrix metalloproteinase-9 and a decline in serum-soluble E-cadherin.

Authors: Karen L Reckamp; Brian K Gardner; Robert A Figlin; David Elashoff; Kostyantyn Krysan; Mariam Dohadwala; Jenny Mao; Sherven Sharma; Landon Inge; Ayyappan Rajasekaran; Steven M Dubinett
Journal: J Thorac Oncol Date: 2008-02 Impact factor: 15.609

9. Direct evidence for epithelial-mesenchymal transitions in breast cancer.

Authors: Anthony J Trimboli; Koichi Fukino; Alain de Bruin; Guo Wei; Lei Shen; Stephan M Tanner; Nicholas Creasap; Thomas J Rosol; Michael L Robinson; Charis Eng; Michael C Ostrowski; Gustavo Leone
Journal: Cancer Res Date: 2008-02-01 Impact factor: 12.701

Review 10. Genetics of kidney development.

Authors: P Ekblom
Journal: Curr Opin Nephrol Hypertens Date: 1996-05 Impact factor: 2.894

374 in total

Review 1. Early growth response transcription factors: key mediators of fibrosis and novel targets for anti-fibrotic therapy.

Authors: Swati Bhattacharyya; Minghua Wu; Feng Fang; Warren Tourtellotte; Carol Feghali-Bostwick; John Varga
Journal: Matrix Biol Date: 2011-04-13 Impact factor: 11.583

2. Eosinophilic esophagitis: epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment.

Authors: Amir F Kagalwalla; Noorain Akhtar; Samantha A Woodruff; Bryan A Rea; Joanne C Masterson; Vincent Mukkada; Kalyan R Parashette; Jian Du; Sophie Fillon; Cheryl A Protheroe; James J Lee; Katie Amsden; Hector Melin-Aldana; Kelley E Capocelli; Glenn T Furuta; Steven J Ackerman
Journal: J Allergy Clin Immunol Date: 2012-04-01 Impact factor: 10.793

3. Epithelial-mesenchymal transition to be or not to be? Is the answer yes and no at the same time?

Authors: Cheng Zhu; Peter R Mertens
Journal: Int Urol Nephrol Date: 2010-04-04 Impact factor: 2.370

4. Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation.

Authors: Chih-Hsien Wu; Sheau-Chung Tang; Po-Hui Wang; Huei Lee; Jiunn-Liang Ko
Journal: J Biol Chem Date: 2012-05-30 Impact factor: 5.157

5. Epithelial-mesenchymal transition: a new target in anticancer drug discovery.

Authors: Fabrizio Marcucci; Giorgio Stassi; Ruggero De Maria
Journal: Nat Rev Drug Discov Date: 2016-01-29 Impact factor: 84.694

6. The effects of pleiotrophin in proliferative vitreoretinopathy.

Authors: Xue Ding; Yujing Bai; Xuemei Zhu; Tianqi Li; Enzhong Jin; Lvzhen Huang; Wenzhen Yu; Mingwei Zhao
Journal: Graefes Arch Clin Exp Ophthalmol Date: 2017-01-12 Impact factor: 3.117

Review 7. Epigenetic regulation of epithelial-mesenchymal transition.

Authors: Lidong Sun; Jia Fang
Journal: Cell Mol Life Sci Date: 2016-07-08 Impact factor: 9.261

8. Bone marrow-derived myofibroblasts are the providers of pro-invasive matrix metalloproteinase 13 in primary tumor.

Authors: Julie Lecomte; Anne Masset; Silvia Blacher; Ludovic Maertens; André Gothot; Marie Delgaudine; Françoise Bruyère; Oriane Carnet; Jenny Paupert; Martin Illemann; Jean-Michel Foidart; Ida K Lund; Gunilla Høyer-Hansen; Agnes Noel
Journal: Neoplasia Date: 2012-10 Impact factor: 5.715

9. Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway.

Authors: Sandeep C Chaudhary; Tripti Singh; Sarang S Talwelkar; Ritesh K Srivastava; Aadithya Arumugam; Zhiping Weng; Craig A Elmets; Farrukh Afaq; Levy Kopelovich; Mohammad Athar
Journal: Cancer Prev Res (Phila) Date: 2013-11-11

Review 10. Epithelial-to-mesenchymal transition in tumor progression.

Authors: Elena Prieto-García; C Vanesa Díaz-García; Inmaculada García-Ruiz; M Teresa Agulló-Ortuño
Journal: Med Oncol Date: 2017-05-30 Impact factor: 3.064