Literature DB >> 26028344

Gardasil 9 joins the fight against cervix cancer.

Jack Cuzick1.   

Abstract

A trial of 14,215 women aged between 16 and 26 years comparing a new vaccine with nine human papilloma virus types - four from the licensed Gardasil vaccine (types 6, 11,16 and 18) and five new ones (types 31, 33, 45, 52 and 58) to Gardasil - has shown improved protection against cervical cancer precursor lesions. Antibody response for the four original Gardasil types was not inferior and a 96.3% reduction in high-grade cervical disease for the other five types not in Gardasil was seen in the per-protocol population. Six-month persistent infection was reduced by 96% for these types. There were no serious safety concerns, although injection site reactions were more common with the new vaccine.

Entities:  

Keywords:  9-valent vaccine; Gardasil; cervical disease; human papilloma virus; vaccination

Mesh:

Substances:

Year:  2015        PMID: 26028344     DOI: 10.1586/14760584.2015.1051470

Source DB:  PubMed          Journal:  Expert Rev Vaccines        ISSN: 1476-0584            Impact factor:   5.217


  23 in total

1.  Therapeutic DNA Vaccines for Human Papillomavirus and Associated Diseases.

Authors:  Max A Cheng; Emily Farmer; Claire Huang; John Lin; Chien-Fu Hung; T-C Wu
Journal:  Hum Gene Ther       Date:  2018-03-16       Impact factor: 5.695

Review 2.  Human Papillomavirus Vaccines: Successes and Future Challenges.

Authors:  Samara Perez; Gregory D Zimet; Ovidiu Tatar; Nathan W Stupiansky; William A Fisher; Zeev Rosberger
Journal:  Drugs       Date:  2018-09       Impact factor: 9.546

Review 3.  Design of virus-based nanomaterials for medicine, biotechnology, and energy.

Authors:  Amy M Wen; Nicole F Steinmetz
Journal:  Chem Soc Rev       Date:  2016-07-25       Impact factor: 54.564

Review 4.  Trial watch: DNA-based vaccines for oncological indications.

Authors:  Stefano Pierini; Renzo Perales-Linares; Mireia Uribe-Herranz; Jonathan G Pol; Laurence Zitvogel; Guido Kroemer; Andrea Facciabene; Lorenzo Galluzzi
Journal:  Oncoimmunology       Date:  2017-11-20       Impact factor: 8.110

Review 5.  Expanded strain coverage for a highly successful public health tool: Prophylactic 9-valent human papillomavirus vaccine.

Authors:  Zhigang Zhang; Jun Zhang; Ningshao Xia; Qinjian Zhao
Journal:  Hum Vaccin Immunother       Date:  2017-10-03       Impact factor: 3.452

6.  Durability of Cross-Protection by Different Schedules of the Bivalent HPV Vaccine: The CVT Trial.

Authors:  Sabrina H Tsang; Joshua N Sampson; John Schussler; Carolina Porras; Sarah Wagner; Joseph Boland; Bernal Cortes; Douglas R Lowy; John T Schiller; Mark Schiffman; Troy J Kemp; Ana Cecilia Rodriguez; Wim Quint; Mitchell H Gail; Ligia A Pinto; Paula Gonzalez; Allan Hildesheim; Aimée R Kreimer; Rolando Herrero
Journal:  J Natl Cancer Inst       Date:  2020-10-01       Impact factor: 13.506

7.  Why does infection with some helminths cause cancer?

Authors:  Paul J Brindley; José M Correia da Costa; Banchob Sripa
Journal:  Trends Cancer       Date:  2015-11-01

8.  Genital Dysplasia and Immunosuppression: Why Organ-Specific Therapy Is Important.

Authors:  Raphael Sager; Pascal Frei; Urs C Steiner; Daniel Fink; Cornelia Betschart
Journal:  Inflamm Intest Dis       Date:  2019-09-17

Review 9.  Cervical Cancer Immunotherapy: Facts and Hopes.

Authors:  Louise Ferrall; Ken Y Lin; Richard B S Roden; Chien-Fu Hung; T-C Wu
Journal:  Clin Cancer Res       Date:  2021-04-22       Impact factor: 12.531

Review 10.  Vaccines for immunoprevention of cancer.

Authors:  Tomohiro Enokida; Alvaro Moreira; Nina Bhardwaj
Journal:  J Clin Invest       Date:  2021-05-03       Impact factor: 14.808

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