Akiko Shida1, Nobue Futawatari1, Takashi Fukuyama2, Yoshinobu Ichiki3, Yoshihito Takahashi4, Yatsushi Nishi4, Noritada Kobayashi5, Hitoshi Yamazaki6, Masahiko Watanabe7. 1. Division of Surgery, Kitasato University Medical Center, Kitamoto, Saitama, Japan Division of Surgery, Kitasato University, Sagamihara, Kanagawa, Japan. 2. Division of Biomedical Research, Kitasato University Medical Center, Kitamoto, Saitama, Japan fukuyam@insti.kitasato-u.ac.jp. 3. Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan. 4. Division of Surgery, Kitasato University Medical Center, Kitamoto, Saitama, Japan. 5. Division of Biomedical Research, Kitasato University Medical Center, Kitamoto, Saitama, Japan. 6. Division of Pathology, Kitasato University Medical Center, Kitamoto, Saitama, Japan. 7. Division of Surgery, Kitasato University, Sagamihara, Kanagawa, Japan.
Abstract
BACKGROUND: The tumor-associated antigen Kita-Kyushu lung cancer antigen-1 (KK-LC-1) has been reported as not being expressed in normal tissues, except for the testis, and in the setting of non-small cell lung cancer. The present study demonstrated that KK-LC-1 is expressed in gastric cancer. MATERIALS AND METHODS: We analyzed the expression of KK-LC-1 and cancer/testis antigens (CTAs) in surgical specimens of 49 gastric carcinomas. The expression of KK-LC-1 and CTAs was assessed using reverse transcription-polymerase chain reaction. RESULTS: KK-LC-1 expression was observed in gastric carcinomas. The number of lesions with expression of KK-LC-1, Melanoma antigen gene encoding-A1 (MAGE-A1), MAGE-A3 and New York Esophageal squamous cell carcinoma-1 (NY-ESO-1) was 40 (81.6%), 17 (34.7%), 22 (44.9%) and 8 (16.3%) out of the 49 specimens, respectively. CONCLUSION: KK-LC-1 should be categorized as a CTA. The frequency of KK-LC-1 expression was higher than that of the other CTAs. KK-LC-1 might be a useful target for immunotherapy and in diagnosis of gastric cancer. Copyright
BACKGROUND: The tumor-associated antigen Kita-Kyushu lung cancer antigen-1 (KK-LC-1) has been reported as not being expressed in normal tissues, except for the testis, and in the setting of non-small cell lung cancer. The present study demonstrated that KK-LC-1 is expressed in gastric cancer. MATERIALS AND METHODS: We analyzed the expression of KK-LC-1 and cancer/testis antigens (CTAs) in surgical specimens of 49 gastric carcinomas. The expression of KK-LC-1 and CTAs was assessed using reverse transcription-polymerase chain reaction. RESULTS:KK-LC-1 expression was observed in gastric carcinomas. The number of lesions with expression of KK-LC-1, Melanoma antigen gene encoding-A1 (MAGE-A1), MAGE-A3 and New York Esophageal squamous cell carcinoma-1 (NY-ESO-1) was 40 (81.6%), 17 (34.7%), 22 (44.9%) and 8 (16.3%) out of the 49 specimens, respectively. CONCLUSION:KK-LC-1 should be categorized as a CTA. The frequency of KK-LC-1 expression was higher than that of the other CTAs. KK-LC-1 might be a useful target for immunotherapy and in diagnosis of gastric cancer. Copyright
Authors: Bridget Marcinkowski; Sanja Stevanović; Sarah R Helman; Scott M Norberg; Carylinda Serna; Benjamin Jin; Nikolaos Gkitsas; Tejas Kadakia; Andrew Warner; Jeremy L Davis; Lisa Rooper; Christian S Hinrichs Journal: J Immunother Cancer Date: 2019-08-28 Impact factor: 13.751