Tin A Tun1, Chen-Hsin Sun2, Mani Baskaran3, Michael J A Girard4, John Mark S de Leon5, Ching-Yu Cheng3, Hla M Htoon6, Tien Y Wong3, Tin Aung3, Nicholas G Strouthidis7. 1. Singapore Eye Research Institute and Singapore National Eye Centre, Singapore. 2. Duke-National University of Singapore (NUS) Graduate Medical School, National University of Singapore, Singapore 3Department of Ophthalmology, National University Health System, Singapore. 3. Singapore Eye Research Institute and Singapore National Eye Centre, Singapore 2Duke-National University of Singapore (NUS) Graduate Medical School, National University of Singapore, Singapore 4Department of Ophthalmology, Yong Loo Lin School of Medicine. 4. Singapore Eye Research Institute and Singapore National Eye Centre, Singapore 5In Vivo Biomechanics Laboratory, Department of Biomedical Engineering, National University of Singapore, Singapore. 5. Cardinal Santos Medical Center, Metro Manila, Philippines. 6. Singapore Eye Research Institute and Singapore National Eye Centre, Singapore 2Duke-National University of Singapore (NUS) Graduate Medical School, National University of Singapore, Singapore. 7. Singapore Eye Research Institute and Singapore National Eye Centre, Singapore 7National Institute for Health Research (NIHR) Biomedical Research Centre, Moorfields Eye Hospital National Health Service (NHS) Foundation Trust and University College London (
Abstract
PURPOSE: To characterize an optical coherence tomography (OCT)-derived parameter, Bruch's membrane opening-minimum rim width (BMO-MRW), and its association with demographic and clinical parameters in normal Chinese subjects. METHODS: Right eyes of 466 consecutive healthy subjects from a population-based study of Singaporean Chinese underwent Cirrus OCT imaging. The retinal internal limiting membrane (ILM) and BMO were automatically delineated using the built-in Cirrus algorithm. The standard 36 interpolated radial B-scans (72 BMO points, 5° increments) of each optic nerve head were manually extracted from the central circle (3.46-mm diameter). We used Matlab to measure the shortest distance from the BMO points to the ILM. Associations of BMO-MRW with demographic and clinical parameters were evaluated using marginal general estimating equations analysis. RESULTS: There was a slight preponderance of male subjects (50.9%), with a mean age of 54.8 ± 7.63 years. Mean BMO-MRW was 304.67 ± 58.96 μm (range, 173.32-529.23 μm), which was highly associated with OCT-derived disc area (DA) (β = -91.78, P < 0.001) and rim area (RA) (β = 194.31, P < 0.001), followed by spherical refractive error (SRE) (β = -2.23, P = 0.02) and retinal nerve fiber layer (RNFL) thickness (β = 0.5, P = 0.04), after adjusting for the associated factors such as age, sex, intraocular pressure (IOP), and vertical cup-disc ratio (VCDR). CONCLUSIONS: Disc area and RA had the strongest association with BMO-MRW, followed by SRE and RNFL thickness. The availability of this normative database will facilitate optic nerve head assessment using the BMO-MRW parameter in Chinese subjects.
PURPOSE: To characterize an optical coherence tomography (OCT)-derived parameter, Bruch's membrane opening-minimum rim width (BMO-MRW), and its association with demographic and clinical parameters in normal Chinese subjects. METHODS: Right eyes of 466 consecutive healthy subjects from a population-based study of Singaporean Chinese underwent Cirrus OCT imaging. The retinal internal limiting membrane (ILM) and BMO were automatically delineated using the built-in Cirrus algorithm. The standard 36 interpolated radial B-scans (72 BMO points, 5° increments) of each optic nerve head were manually extracted from the central circle (3.46-mm diameter). We used Matlab to measure the shortest distance from the BMO points to the ILM. Associations of BMO-MRW with demographic and clinical parameters were evaluated using marginal general estimating equations analysis. RESULTS: There was a slight preponderance of male subjects (50.9%), with a mean age of 54.8 ± 7.63 years. Mean BMO-MRW was 304.67 ± 58.96 μm (range, 173.32-529.23 μm), which was highly associated with OCT-derived disc area (DA) (β = -91.78, P < 0.001) and rim area (RA) (β = 194.31, P < 0.001), followed by spherical refractive error (SRE) (β = -2.23, P = 0.02) and retinal nerve fiber layer (RNFL) thickness (β = 0.5, P = 0.04), after adjusting for the associated factors such as age, sex, intraocular pressure (IOP), and vertical cup-disc ratio (VCDR). CONCLUSIONS: Disc area and RA had the strongest association with BMO-MRW, followed by SRE and RNFL thickness. The availability of this normative database will facilitate optic nerve head assessment using the BMO-MRW parameter in Chinese subjects.
Authors: Tin A Tun; Eray Atalay; Mani Baskaran; Monisha E Nongpiur; Hla M Htoon; David Goh; Ching-Yu Cheng; Shamira A Perera; Tin Aung; Nicholas G Strouthidis; Michaël J A Girard Journal: JAMA Ophthalmol Date: 2018-02-01 Impact factor: 7.389
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