Chia-Jui Tsai1, Charles Tzu-Chi Lee2,3, Sophie Hsin-Yi Liang4,5, Pei-Jung Tsai6, Vincent Chin-Hung Chen5,7, Michael Gossop8. 1. 1 Taichung Veterans General Hospital, Taiwan. 2. 2 Kaohsiung Medical University, Taiwan. 3. 3 National Taiwan Normal University, Taipei, Taiwan. 4. 4 Chang Gung Memorial Hospital, Taoyuan, Taiwan. 5. 5 Chang Gung University, Taoyuan, Taiwan. 6. 6 Lu-Tung Christian Hospital, Changhua, Taiwan. 7. 7 Chiayi Chang Gung Memorial Hospital, Taiwan. 8. 8 King's College London, UK.
Abstract
OBJECTIVE: To study the association between general anesthesia exposure before age 3 years and having a later ADHD diagnosis. METHOD: In a birth cohort, data were collected from a nationwide population database for children born between 1997 and 1999 who were exposed to general anesthesia before their third birthday. Age- and gender-matched enrollees without general anesthesia exposure were taken as the comparison. Groups were compared to identify the incidence of ADHD after age 4 and anesthesia-related predictive factors. RESULTS: Among the 1,146 exposed children, 74 ADHD cases were identified, and 158 ADHD cases were identified in 3,438 matched controls. After adjusting for comorbid conditions and possible confounding factors, if exposure on more than one occasion or ≥3 hr, an increased likelihood of having a later ADHD diagnosis was found (HR, 1.71 and 2.43, respectively). CONCLUSION: Children with multiple or ≥3 hr general anesthesia exposures before age 3 years have an increased likelihood of a later ADHD diagnosis.
OBJECTIVE: To study the association between general anesthesia exposure before age 3 years and having a later ADHD diagnosis. METHOD: In a birth cohort, data were collected from a nationwide population database for children born between 1997 and 1999 who were exposed to general anesthesia before their third birthday. Age- and gender-matched enrollees without general anesthesia exposure were taken as the comparison. Groups were compared to identify the incidence of ADHD after age 4 and anesthesia-related predictive factors. RESULTS: Among the 1,146 exposed children, 74 ADHD cases were identified, and 158 ADHD cases were identified in 3,438 matched controls. After adjusting for comorbid conditions and possible confounding factors, if exposure on more than one occasion or ≥3 hr, an increased likelihood of having a later ADHD diagnosis was found (HR, 1.71 and 2.43, respectively). CONCLUSION:Children with multiple or ≥3 hr general anesthesia exposures before age 3 years have an increased likelihood of a later ADHD diagnosis.
Authors: Marvin So; Eric J Dziuban; Caitlin S Pedati; Joseph R Holbrook; Angelika H Claussen; Brenna O'Masta; Brion Maher; Audrey A Cerles; Zayan Mahmooth; Laurel MacMillan; Jennifer W Kaminski; Margaret Rush Journal: Prev Sci Date: 2022-08-10
Authors: Charles Reighard; Shaqif Junaid; William M Jackson; Ayesha Arif; Hannah Waddington; Andrew J O Whitehouse; Caleb Ing Journal: JAMA Netw Open Date: 2022-06-01