Literature DB >> 26019716

Comorbidity Among Dimensions of Childhood Psychopathology: Converging Evidence from Behavior Genetics.

Soo Hyun Rhee1, Benjamin B Lahey2, Irwin D Waldman3.   

Abstract

In this article, we review evidence from recent behavior genetic studies that examined the covariance among common childhood psychopathological conditions and tested specific hypotheses regarding common and broadband-specific underlying features of childhood psychopathology. Specifically, we review the distinction between internalizing and externalizing disorders, the support for the generalist genes and specialist environments model, negative emotionality as a heritable underlying feature common to both internalizing and externalizing disorders, and daring as a heritable broadband-specific underlying feature that distinguishes externalizing disorders from internalizing disorders. We also discuss the implications of research in the search for specific genes that influence childhood psychopathology and suggest avenues for new research.

Entities:  

Keywords:  behavior genetics; comorbidity; externalizing; internalizing

Year:  2015        PMID: 26019716      PMCID: PMC4442026          DOI: 10.1111/cdep.12102

Source DB:  PubMed          Journal:  Child Dev Perspect        ISSN: 1750-8592


  39 in total

1.  Testing hypotheses regarding the causes of comorbidity: examining the underlying deficits of comorbid disorders.

Authors:  Soo Hyun Rhee; John K Hewitt; Robin P Corley; Erik G Willcutt; Bruce F Pennington
Journal:  J Abnorm Psychol       Date:  2005-08

2.  Age-related changes in heritability of behavioral phenotypes over adolescence and young adulthood: a meta-analysis.

Authors:  Sarah E Bergen; Charles O Gardner; Kenneth S Kendler
Journal:  Twin Res Hum Genet       Date:  2007-06       Impact factor: 1.587

3.  Common and specific features of childhood psychopathology.

Authors:  B Weiss; K Süsser; T Catron
Journal:  J Abnorm Psychol       Date:  1998-02

4.  Shared genetic influences on negative emotionality and major depression/conduct disorder comorbidity.

Authors:  Jennifer L Tackett; Irwin D Waldman; Carol A Van Hulle; Benjamin B Lahey
Journal:  J Am Acad Child Adolesc Psychiatry       Date:  2011-06-25       Impact factor: 8.829

5.  Rare nonsynonymous exonic variants in addiction and behavioral disinhibition.

Authors:  Scott I Vrieze; Shuang Feng; Michael B Miller; Brian M Hicks; Nathan Pankratz; Gonçalo R Abecasis; William G Iacono; Matt McGue
Journal:  Biol Psychiatry       Date:  2013-10-04       Impact factor: 13.382

6.  Psychometric characteristics of a measure of emotional dispositions developed to test a developmental propensity model of conduct disorder.

Authors:  Benjamin B Lahey; Brooks Applegate; Andrea M Chronis; Heather A Jones; Stephanie Hall Williams; Jan Loney; Irwin D Waldman
Journal:  J Clin Child Adolesc Psychol       Date:  2008-10

7.  Personality dimensions as common and broadband-specific features for internalizing and externalizing disorders.

Authors:  Laura K Hink; Soo H Rhee; Robin P Corley; Victoria E Cosgrove; John K Hewitt; Robert J Schulz-Heik; Benjamin B Lahey; Irwin D Waldman
Journal:  J Abnorm Child Psychol       Date:  2013-08

8.  Differential risks of covarying and pure components in mother and teacher reports of externalizing and internalizing behavior across ages 5 to 14.

Authors:  Margaret K Keiley; Nicholas Lofthouse; John E Bates; Kenneth A Dodge; Gregory S Pettit
Journal:  J Abnorm Child Psychol       Date:  2003-06

Review 9.  Common emotional and behavioral disorders in preschool children: presentation, nosology, and epidemiology.

Authors:  Helen Link Egger; Adrian Angold
Journal:  J Child Psychol Psychiatry       Date:  2006 Mar-Apr       Impact factor: 8.982

10.  Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.

Authors:  S Hong Lee; Stephan Ripke; Benjamin M Neale; Stephen V Faraone; Shaun M Purcell; Roy H Perlis; Bryan J Mowry; Anita Thapar; Michael E Goddard; John S Witte; Devin Absher; Ingrid Agartz; Huda Akil; Farooq Amin; Ole A Andreassen; Adebayo Anjorin; Richard Anney; Verneri Anttila; Dan E Arking; Philip Asherson; Maria H Azevedo; Lena Backlund; Judith A Badner; Anthony J Bailey; Tobias Banaschewski; Jack D Barchas; Michael R Barnes; Thomas B Barrett; Nicholas Bass; Agatino Battaglia; Michael Bauer; Mònica Bayés; Frank Bellivier; Sarah E Bergen; Wade Berrettini; Catalina Betancur; Thomas Bettecken; Joseph Biederman; Elisabeth B Binder; Donald W Black; Douglas H R Blackwood; Cinnamon S Bloss; Michael Boehnke; Dorret I Boomsma; Gerome Breen; René Breuer; Richard Bruggeman; Paul Cormican; Nancy G Buccola; Jan K Buitelaar; William E Bunney; Joseph D Buxbaum; William F Byerley; Enda M Byrne; Sian Caesar; Wiepke Cahn; Rita M Cantor; Miguel Casas; Aravinda Chakravarti; Kimberly Chambert; Khalid Choudhury; Sven Cichon; C Robert Cloninger; David A Collier; Edwin H Cook; Hilary Coon; Bru Cormand; Aiden Corvin; William H Coryell; David W Craig; Ian W Craig; Jennifer Crosbie; Michael L Cuccaro; David Curtis; Darina Czamara; Susmita Datta; Geraldine Dawson; Richard Day; Eco J De Geus; Franziska Degenhardt; Srdjan Djurovic; Gary J Donohoe; Alysa E Doyle; Jubao Duan; Frank Dudbridge; Eftichia Duketis; Richard P Ebstein; Howard J Edenberg; Josephine Elia; Sean Ennis; Bruno Etain; Ayman Fanous; Anne E Farmer; I Nicol Ferrier; Matthew Flickinger; Eric Fombonne; Tatiana Foroud; Josef Frank; Barbara Franke; Christine Fraser; Robert Freedman; Nelson B Freimer; Christine M Freitag; Marion Friedl; Louise Frisén; Louise Gallagher; Pablo V Gejman; Lyudmila Georgieva; Elliot S Gershon; Daniel H Geschwind; Ina Giegling; Michael Gill; Scott D Gordon; Katherine Gordon-Smith; Elaine K Green; Tiffany A Greenwood; Dorothy E Grice; Magdalena Gross; Detelina Grozeva; Weihua Guan; Hugh Gurling; Lieuwe De Haan; Jonathan L Haines; Hakon Hakonarson; Joachim Hallmayer; Steven P Hamilton; Marian L Hamshere; Thomas F Hansen; Annette M Hartmann; Martin Hautzinger; Andrew C Heath; Anjali K Henders; Stefan Herms; Ian B Hickie; Maria Hipolito; Susanne Hoefels; Peter A Holmans; Florian Holsboer; Witte J Hoogendijk; Jouke-Jan Hottenga; Christina M Hultman; Vanessa Hus; Andrés Ingason; Marcus Ising; Stéphane Jamain; Edward G Jones; Ian Jones; Lisa Jones; Jung-Ying Tzeng; Anna K Kähler; René S Kahn; Radhika Kandaswamy; Matthew C Keller; James L Kennedy; Elaine Kenny; Lindsey Kent; Yunjung Kim; George K Kirov; Sabine M Klauck; Lambertus Klei; James A Knowles; Martin A Kohli; Daniel L Koller; Bettina Konte; Ania Korszun; Lydia Krabbendam; Robert Krasucki; Jonna Kuntsi; Phoenix Kwan; Mikael Landén; Niklas Långström; Mark Lathrop; Jacob Lawrence; William B Lawson; Marion Leboyer; David H Ledbetter; Phil H Lee; Todd Lencz; Klaus-Peter Lesch; Douglas F Levinson; Cathryn M Lewis; Jun Li; Paul Lichtenstein; Jeffrey A Lieberman; Dan-Yu Lin; Don H Linszen; Chunyu Liu; Falk W Lohoff; Sandra K Loo; Catherine Lord; Jennifer K Lowe; Susanne Lucae; Donald J MacIntyre; Pamela A F Madden; Elena Maestrini; Patrik K E Magnusson; Pamela B Mahon; Wolfgang Maier; Anil K Malhotra; Shrikant M Mane; Christa L Martin; Nicholas G Martin; Manuel Mattheisen; Keith Matthews; Morten Mattingsdal; Steven A McCarroll; Kevin A McGhee; James J McGough; Patrick J McGrath; Peter McGuffin; Melvin G McInnis; Andrew McIntosh; Rebecca McKinney; Alan W McLean; Francis J McMahon; William M McMahon; Andrew McQuillin; Helena Medeiros; Sarah E Medland; Sandra Meier; Ingrid Melle; Fan Meng; Jobst Meyer; Christel M Middeldorp; Lefkos Middleton; Vihra Milanova; Ana Miranda; Anthony P Monaco; Grant W Montgomery; Jennifer L Moran; Daniel Moreno-De-Luca; Gunnar Morken; Derek W Morris; Eric M Morrow; Valentina Moskvina; Pierandrea Muglia; Thomas W Mühleisen; Walter J Muir; Bertram Müller-Myhsok; Michael Murtha; Richard M Myers; Inez Myin-Germeys; Michael C Neale; Stan F Nelson; Caroline M Nievergelt; Ivan Nikolov; Vishwajit Nimgaonkar; Willem A Nolen; Markus M Nöthen; John I Nurnberger; Evaristus A Nwulia; Dale R Nyholt; Colm O'Dushlaine; Robert D Oades; Ann Olincy; Guiomar Oliveira; Line Olsen; Roel A Ophoff; Urban Osby; Michael J Owen; Aarno Palotie; Jeremy R Parr; Andrew D Paterson; Carlos N Pato; Michele T Pato; Brenda W Penninx; Michele L Pergadia; Margaret A Pericak-Vance; Benjamin S Pickard; Jonathan Pimm; Joseph Piven; Danielle Posthuma; James B Potash; Fritz Poustka; Peter Propping; Vinay Puri; Digby J Quested; Emma M Quinn; Josep Antoni Ramos-Quiroga; Henrik B Rasmussen; Soumya Raychaudhuri; Karola Rehnström; Andreas Reif; Marta Ribasés; John P Rice; Marcella Rietschel; Kathryn Roeder; Herbert Roeyers; Lizzy Rossin; Aribert Rothenberger; Guy Rouleau; Douglas Ruderfer; Dan Rujescu; Alan R Sanders; Stephan J Sanders; Susan L Santangelo; Joseph A Sergeant; Russell Schachar; Martin Schalling; Alan F Schatzberg; William A Scheftner; Gerard D Schellenberg; Stephen W Scherer; Nicholas J Schork; Thomas G Schulze; Johannes Schumacher; Markus Schwarz; Edward Scolnick; Laura J Scott; Jianxin Shi; Paul D Shilling; Stanley I Shyn; Jeremy M Silverman; Susan L Slager; Susan L Smalley; Johannes H Smit; Erin N Smith; Edmund J S Sonuga-Barke; David St Clair; Matthew State; Michael Steffens; Hans-Christoph Steinhausen; John S Strauss; Jana Strohmaier; T Scott Stroup; James S Sutcliffe; Peter Szatmari; Szabocls Szelinger; Srinivasa Thirumalai; Robert C Thompson; Alexandre A Todorov; Federica Tozzi; Jens Treutlein; Manfred Uhr; Edwin J C G van den Oord; Gerard Van Grootheest; Jim Van Os; Astrid M Vicente; Veronica J Vieland; John B Vincent; Peter M Visscher; Christopher A Walsh; Thomas H Wassink; Stanley J Watson; Myrna M Weissman; Thomas Werge; Thomas F Wienker; Ellen M Wijsman; Gonneke Willemsen; Nigel Williams; A Jeremy Willsey; Stephanie H Witt; Wei Xu; Allan H Young; Timothy W Yu; Stanley Zammit; Peter P Zandi; Peng Zhang; Frans G Zitman; Sebastian Zöllner; Bernie Devlin; John R Kelsoe; Pamela Sklar; Mark J Daly; Michael C O'Donovan; Nicholas Craddock; Patrick F Sullivan; Jordan W Smoller; Kenneth S Kendler; Naomi R Wray
Journal:  Nat Genet       Date:  2013-08-11       Impact factor: 38.330

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  36 in total

1.  Inhibitory control and emotion dysregulation: A framework for research on anxiety.

Authors:  Elise M Cardinale; Anni R Subar; Melissa A Brotman; Ellen Leibenluft; Katharina Kircanski; Daniel S Pine
Journal:  Dev Psychopathol       Date:  2019-04-10

2.  Implications of the Hierarchical Structure of Psychopathology for Psychiatric Neuroimaging.

Authors:  David H Zald; Benjamin B Lahey
Journal:  Biol Psychiatry Cogn Neurosci Neuroimaging       Date:  2017-05

Review 3.  Coping, emotion regulation, and psychopathology in childhood and adolescence: A meta-analysis and narrative review.

Authors:  Bruce E Compas; Sarah S Jaser; Alexandra H Bettis; Kelly H Watson; Meredith A Gruhn; Jennifer P Dunbar; Ellen Williams; Jennifer C Thigpen
Journal:  Psychol Bull       Date:  2017-06-15       Impact factor: 17.737

4.  The Perspective Matters: A Multi-informant Study on the Relationship Between Social-Emotional Competence and Preschoolers' Externalizing and Internalizing Symptoms.

Authors:  Laura Huber; Maria Plötner; Tina In-Albon; Stephanie Stadelmann; Julian Schmitz
Journal:  Child Psychiatry Hum Dev       Date:  2019-12

Review 5.  Atypical fetal development: Fetal alcohol syndrome, nutritional deprivation, teratogens, and risk for neurodevelopmental disorders and psychopathology.

Authors:  Michael K Georgieff; Phu V Tran; Erik S Carlson
Journal:  Dev Psychopathol       Date:  2018-08

6.  The dynamics of internalizing and externalizing comorbidity across the early school years.

Authors:  Cynthia J Willner; Lisa M Gatzke-Kopp; Bethany C Bray
Journal:  Dev Psychopathol       Date:  2016-11

7.  Transdiagnostic factors and pathways to multifinality: The error-related negativity predicts whether preschool irritability is associated with internalizing versus externalizing symptoms at age 9.

Authors:  Ellen M Kessel; Alexandria Meyer; Greg Hajcak; Lea R Dougherty; Dana C Torpey-Newman; Gabrielle A Carlson; Daniel N Klein
Journal:  Dev Psychopathol       Date:  2016-11

8.  Do executive functions explain the covariance between internalizing and externalizing behaviors?

Authors:  Alexander S Hatoum; Soo Hyun Rhee; Robin P Corley; John K Hewitt; Naomi P Friedman
Journal:  Dev Psychopathol       Date:  2017-11-16

Review 9.  Transdiagnostic impairment of cognitive control in mental illness.

Authors:  Lisa M McTeague; Madeleine S Goodkind; Amit Etkin
Journal:  J Psychiatr Res       Date:  2016-08-05       Impact factor: 4.791

10.  Unique Associations between Childhood Temperament Characteristics and Subsequent Psychopathology Symptom Trajectories from Childhood to Early Adolescence.

Authors:  Miriam K Forbes; Ronald M Rapee; Anna-Lisa Camberis; Catherine A McMahon
Journal:  J Abnorm Child Psychol       Date:  2017-08
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