Oscar Santos1, Mauricio Londoño2, Juan Marín1, Octavio Muñoz1, Álvaro Mena3, Carlos Guzmán3, Sergio Hoyos1, Juan Restrepo1, María Arbeláez4, Gonzalo Correa1. 1. Hepatology and Liver Transplantation Unit, Pablo Tobon Uribe Hospital, Medellin, Colombia ; Gastrohepatology Research Group, University of Antioquia, Medellin, Colombia. 2. Gastrohepatology Research Group, University of Antioquia, Medellin, Colombia. 3. Hepatology and Liver Transplantation Unit, Pablo Tobon Uribe Hospital, Medellin, Colombia. 4. Epidemiology Research Group, National Faculty of Public Health, University of Antioquia, Medellin, Colombia.
Abstract
OBJECTIVES: Liver transplantation is the treatment of choice for acute and chronic liver failure, for selected cases of tumors, and for conditions resulting from errors in metabolism. This paper reports the experience of a medical center in Latin America. METHODS: Were conducted 305 orthotopic liver transplantations on 284 patients between 2004 and 2010. Of these patients, 241 were adults undergoing their first transplantation. RESULTS: The average age of patients was 52 years old, and 62% of the individuals were male. The most common indication was alcoholic cirrhosis. The rate of patient survival after 1 and 5 years was 82 and 72% respectively. The rate of liver graft survival after 1 and 5 years was 78 and 68% respectively. The main cause of death was sepsis. Complications in the hepatic artery were documented for 5% of the patients. Additionally, 14.5% of the patients had complications in the biliary tract. Infections were found in 41% of the individuals. Acute rejection was observed in 30% of the subjects, and chronic rejection in 3%. CONCLUSION: In conclusion, liver transplantation at our medical center in Colombia offers good mid-term results, with a complication rate similar to that reported by other centers around the world.
OBJECTIVES: Liver transplantation is the treatment of choice for acute and chronic liver failure, for selected cases of tumors, and for conditions resulting from errors in metabolism. This paper reports the experience of a medical center in Latin America. METHODS: Were conducted 305 orthotopic liver transplantations on 284 patients between 2004 and 2010. Of these patients, 241 were adults undergoing their first transplantation. RESULTS: The average age of patients was 52 years old, and 62% of the individuals were male. The most common indication was alcoholic cirrhosis. The rate of patient survival after 1 and 5 years was 82 and 72% respectively. The rate of liver graft survival after 1 and 5 years was 78 and 68% respectively. The main cause of death was sepsis. Complications in the hepatic artery were documented for 5% of the patients. Additionally, 14.5% of the patients had complications in the biliary tract. Infections were found in 41% of the individuals. Acute rejection was observed in 30% of the subjects, and chronic rejection in 3%. CONCLUSION: In conclusion, liver transplantation at our medical center in Colombia offers good mid-term results, with a complication rate similar to that reported by other centers around the world.
Authors: P R Pfau; M L Kochman; J D Lewis; W B Long; M R Lucey; K Olthoff; A Shaked; G G Ginsberg Journal: Gastrointest Endosc Date: 2000-07 Impact factor: 9.427
Authors: S Mies; C E S Baia; M D Almeida; B Della Guardia; L R Ferraz; M P Lallée; P C B Massarollo; A O N G F Mies; O I Pereira; E Quintela; A S C Zan; S Raia Journal: Transplant Proc Date: 2006 Jul-Aug Impact factor: 1.066
Authors: Rungsun Rerknimitr; Stuart Sherman; Evan L Fogel; Cem Kalayci; Lawrence Lumeng; Naga Chalasani; Paul Kwo; Glen A Lehman Journal: Gastrointest Endosc Date: 2002-02 Impact factor: 9.427
Authors: R S Castro; D Deisanti; T Seva-Pereira; J R S Almeida; A Yamanaka; I F S F Boin; E C Soares Journal: Transplant Proc Date: 2010-03 Impact factor: 1.066
Authors: Robert Pfitzmann; Natascha C Nüssler; Michael Hippler-Benscheidt; Ruth Neuhaus; Peter Neuhaus Journal: Transpl Int Date: 2007-11-21 Impact factor: 3.782
Authors: John P Duffy; Johnny C Hong; Douglas G Farmer; Rafik M Ghobrial; Hasan Yersiz; Jonathan R Hiatt; Ronald W Busuttil Journal: J Am Coll Surg Date: 2009-05 Impact factor: 6.113
Authors: V Mazzaferro; E Regalia; R Doci; S Andreola; A Pulvirenti; F Bozzetti; F Montalto; M Ammatuna; A Morabito; L Gennari Journal: N Engl J Med Date: 1996-03-14 Impact factor: 176.079
Authors: Christian S Alvarez; Elisa Hernández; Kira Escobar; Carmen I Villagrán; María F Kroker-Lobos; Alvaro Rivera-Andrade; Joshua W Smith; Patricia A Egner; Mariana Lazo; Neal D Freedman; Eliseo Guallar; Michael Dean; Barry I Graubard; John D Groopman; Manuel Ramírez-Zea; Katherine A McGlynn Journal: BMJ Open Gastroenterol Date: 2020-07