Literature DB >> 26014947

In Vitro Susceptibility of Leishmania infantum to Artemisinin Derivatives and Selected Trioxolanes.

Sofia Cortes1, Andreia Albuquerque2, Lília I L Cabral3, Liliana Lopes4, Lenea Campino5, Maria L S Cristiano6.   

Abstract

Leishmaniasis is among the world's most neglected diseases. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs. A small library of artemisinin-derived trioxanes and synthetic trioxolanes was tested against promastigote and intramacrophage amastigote forms of Leishmania infantum. The trioxolanes LC50 and LC95 presented the best activity and safety profiles, showing potential for further studies in the context of leishmanial therapy. Our results indicate that the compounds tested exhibit peroxide-dependent activity.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26014947      PMCID： PMC4505222          DOI： 10.1128/AAC.00298-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  In vitro antileishmanial activity of fluoro-artemisinin derivatives against Leishmania donovani.

Authors:  Constance Chollet; Benoît Crousse; Christian Bories; Danièle Bonnet-Delpon; Philippe M Loiseau
Journal:  Biomed Pharmacother       Date:  2008-05-15       Impact factor: 6.529

2.  The comparative antimalarial properties of weak base and neutral synthetic ozonides.

Authors:  Yuanqing Tang; Sergio Wittlin; Susan A Charman; Jacques Chollet; Francis C K Chiu; Julia Morizzi; Lisa M Johnson; Josefina Santo Tomas; Christian Scheurer; Chistopher Snyder; Lin Zhou; Yuxiang Dong; William N Charman; Hugues Matile; Heinrich Urwyler; Arnulf Dorn; Jonathan L Vennerstrom
Journal:  Bioorg Med Chem Lett       Date:  2009-11-22       Impact factor: 2.823

3.  Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep.

Authors:  Jennifer Keiser; Carla Kirchhofer; Manuel Haschke; Jörg Huwyler; Yuxiang Dong; Jonathan L Vennerstrom; Kathleen Vanhoff; Ronald Kaminsky; Nick Malikides
Journal:  Vet Parasitol       Date:  2010-06-25       Impact factor: 2.738

4.  Peroxides with antiplasmodial activity inhibit proliferation of Perkinsus olseni, the causative agent of Perkinsosis in bivalves.

Authors:  N C P Araujo; R Afonso; A Bringela; M L Cancela; M L S Cristiano; R B Leite
Journal:  Parasitol Int       Date:  2013-07-04       Impact factor: 2.230

5.  Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals.

Authors:  Matthias A Fügi; Sergio Wittlin; Yuxiang Dong; Jonathan L Vennerstrom
Journal:  Antimicrob Agents Chemother       Date:  2009-12-22       Impact factor: 5.191

6.  Weak base dispiro-1,2,4-trioxolanes: potent antimalarial ozonides.

Authors:  Yuanqing Tang; Yuxiang Dong; Sergio Wittlin; Susan A Charman; Jacques Chollet; Francis C K Chiu; William N Charman; Hugues Matile; Heinrich Urwyler; Arnulf Dorn; Saroj Bajpai; Xiaofang Wang; Maniyan Padmanilayam; Jean M Karle; Reto Brun; Jonathan L Vennerstrom
Journal:  Bioorg Med Chem Lett       Date:  2006-12-15       Impact factor: 2.823

7.  Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.

Authors:  Yuxiang Dong; Jacques Chollet; Hugues Matile; Susan A Charman; Francis C K Chiu; William N Charman; Bernard Scorneaux; Heinrich Urwyler; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Arnulf Dorn; Xiaofang Wang; Jean M Karle; Yuanqing Tang; Sergio Wittlin; Reto Brun; Jonathan L Vennerstrom
Journal:  J Med Chem       Date:  2005-07-28       Impact factor: 7.446

8.  Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability.

Authors:  F Denizot; R Lang
Journal:  J Immunol Methods       Date:  1986-05-22       Impact factor: 2.303

9.  Infectivity of five different types of macrophages by Leishmania infantum.

Authors:  C Maia; N Rolão; M Nunes; L Gonçalves; L Campino
Journal:  Acta Trop       Date:  2007-06-07       Impact factor: 3.112

Review 10.  Spread of vector-borne diseases and neglect of Leishmaniasis, Europe.

Authors:  Jean-Claude Dujardin; Lenea Campino; Carmen Cañavate; Jean-Pierre Dedet; Luigi Gradoni; Ketty Soteriadou; Apostolos Mazeris; Yusuf Ozbel; Marleen Boelaert
Journal:  Emerg Infect Dis       Date:  2008-07       Impact factor: 6.883
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  8 in total

1.  Dihydroartemisinin, an active metabolite of artemisinin, interferes with Leishmania braziliensis mitochondrial bioenergetics and survival.

Authors:  Nathalia Grazzia; Sinésio Boaventura; Vera Lucia Garcia; Fernanda R Gadelha; Danilo C Miguel
Journal:  Parasitol Res       Date:  2021-01-08       Impact factor: 2.289

Review 2.  Artemisinin and its derivatives in treating protozoan infections beyond malaria.

Authors:  Cecilia Shi Ni Loo; Nelson Siu Kei Lam; Deying Yu; Xin-Zhuan Su; Fangli Lu
Journal:  Pharmacol Res       Date:  2016-11-17       Impact factor: 7.658

3.  Activation of artemisinin and heme degradation in Leishmania tarentolae promastigotes: A possible link.

Authors:  Gerald Geroldinger; Matthias Tonner; Judith Quirgst; Martin Walter; Sritama De Sarkar; Laura Machín; Lianet Monzote; Klaus Stolze; J Catharina Duvigneau; Katrin Staniek; Mitali Chatterjee; Lars Gille
Journal:  Biochem Pharmacol       Date:  2019-11-29       Impact factor: 5.858

4.  1,2,4-Trioxolane and 1,2,4,5-Tetraoxane Endoperoxides against Old-World Leishmania Parasites: In Vitro Activity and Mode of Action.

Authors:  Andreia Mendes; Ana Armada; Lília I L Cabral; Patrícia S M Amado; Lenea Campino; Maria L S Cristiano; Sofia Cortes
Journal:  Pharmaceuticals (Basel)       Date:  2022-04-03

5.  Synthesis, Structure and Antileishmanial Evaluation of Endoperoxide-Pyrazole Hybrids.

Authors:  Patrícia S M Amado; Inês C C Costa; José A Paixão; Ricardo F Mendes; Sofia Cortes; Maria L S Cristiano
Journal:  Molecules       Date:  2022-08-24       Impact factor: 4.927

Review 6.  Antimalarial Agents as Therapeutic Tools Against Toxoplasmosis-A Short Bridge between Two Distant Illnesses.

Authors:  Alina Secrieru; Inês C C Costa; Paul M O'Neill; Maria L S Cristiano
Journal:  Molecules       Date:  2020-03-30       Impact factor: 4.411

7.  In-vitro and In-vivo Antileishmanial Activity of a Compound Derived of Platinum, Oxaliplatin, against Leishmania Major.

Authors:  Ezatollah Ghasemi; Fatemeh Ghaffarifar; Abdolhossein Dalimi; Javid Sadraei
Journal:  Iran J Pharm Res       Date:  2019       Impact factor: 1.696

8.  Evaluation of the Pharmacophoric Role of the O-O Bond in Synthetic Antileishmanial Compounds: Comparison between 1,2-Dioxanes and Tetrahydropyrans.

Authors:  Margherita Ortalli; Stefania Varani; Giorgia Cimato; Ruben Veronesi; Arianna Quintavalla; Marco Lombardo; Magda Monari; Claudio Trombini
Journal:  J Med Chem       Date:  2020-10-22       Impact factor: 7.446
  8 in total

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