| Literature DB >> 19962893 |
Yuanqing Tang1, Sergio Wittlin, Susan A Charman, Jacques Chollet, Francis C K Chiu, Julia Morizzi, Lisa M Johnson, Josefina Santo Tomas, Christian Scheurer, Chistopher Snyder, Lin Zhou, Yuxiang Dong, William N Charman, Hugues Matile, Heinrich Urwyler, Arnulf Dorn, Jonathan L Vennerstrom.
Abstract
Thirty-three N-acyl 1,2,4-dispiro trioxolanes (secondary ozonides) were synthesized. For these ozonides, weak base functional groups were not required for high antimalarial potency against Plasmodium falciparum in vitro, but were necessary for high antimalarial efficacy in Plasmodium berghei-infected mice. A wide range of LogP/D(pH)(7.4) values were tolerated, although more lipophilic ozonides tended to be less metabolically stable. Copyright 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 19962893 DOI： 10.1016/j.bmcl.2009.11.088
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823