Lorelle Weiss1, Tye E Arbuckle2, Mandy Fisher3, Tim Ramsay4, Ranjeeta Mallick5, Russ Hauser6, Alain LeBlanc7, Mark Walker5, Pierre Dumas7, Carly Lang3. 1. Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada; The University of Ottawa, Ottawa, ON, Canada. 2. Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada. Electronic address: Tye.Arbuckle@hc-sc.gc.ca. 3. Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada. 4. The Ottawa Hospital Research Institute, Ottawa, ON, Canada; The University of Ottawa, Ottawa, ON, Canada. 5. The Ottawa Hospital Research Institute, Ottawa, ON, Canada. 6. Harvard School of Public Health, Boston, MA, USA. 7. Centre de toxicologie du Québec, Institut national de santé publique du Québec, Québec, QC, Canada.
Abstract
BACKGROUND: Triclosan (TCS) is an antibacterial agent commonly added to personal care products. Some animal research studies have associated TCS exposure with androgenic and thyroid effects, as well as endocrine disruption, contact dermatitis and skin irritation. Limited Canadian data exist on exposure levels, temporal variability and sources of exposure to TCS, especially among pregnant women. METHODS: Single and serial spot urine samples (n=1249), as well as consumer product use information were collected over 5 study visits across pregnancy and post-partum from 80 healthy pregnant women in Ottawa, Canada. Urine samples were analyzed for TCS by GC-MS-MS. Summary statistics, linear mixed effects models, and surrogate category analysis were used to describe the results. RESULTS: Triclosan was detected in 87% of maternal urine samples (LOD=3.0μg/L). The geometric mean TCS concentration of all urine samples was 21.6μg/L (95% CI 18.2-25.7). Triclosan concentrations were significantly higher when the urine was collected before 16:00, in the autumn, and more than 90min since last void, and in nulliparous women with household incomes greater than $100,000. A significant correlation was observed between maternal urinary TCS concentrations and number of reported uses of TCS-containing products. The ability of a single spot urine sample collected at any time during or post-pregnancy to predict an individual's geometric mean urinary TCS level corresponding to low, medium, or high exposure was 86.7%. Intraclass correlation coefficients indicated high reproducibility within a week-day (0.77) and week-end day (0.79) and moderate reproducibility across the study period (0.50). CONCLUSIONS: This study provided the first data on temporal variability of urinary TCS concentrations and predictors of exposure in Canadian pregnant women. These results can inform exposure assessments in pregnant women and justify collection of single spot urine samples in epidemiologic studies, especially for women with higher exposures. Crown
BACKGROUND:Triclosan (TCS) is an antibacterial agent commonly added to personal care products. Some animal research studies have associated TCS exposure with androgenic and thyroid effects, as well as endocrine disruption, contact dermatitis and skin irritation. Limited Canadian data exist on exposure levels, temporal variability and sources of exposure to TCS, especially among pregnant women. METHODS: Single and serial spot urine samples (n=1249), as well as consumer product use information were collected over 5 study visits across pregnancy and post-partum from 80 healthy pregnant women in Ottawa, Canada. Urine samples were analyzed for TCS by GC-MS-MS. Summary statistics, linear mixed effects models, and surrogate category analysis were used to describe the results. RESULTS:Triclosan was detected in 87% of maternal urine samples (LOD=3.0μg/L). The geometric mean TCS concentration of all urine samples was 21.6μg/L (95% CI 18.2-25.7). Triclosan concentrations were significantly higher when the urine was collected before 16:00, in the autumn, and more than 90min since last void, and in nulliparous women with household incomes greater than $100,000. A significant correlation was observed between maternal urinary TCS concentrations and number of reported uses of TCS-containing products. The ability of a single spot urine sample collected at any time during or post-pregnancy to predict an individual's geometric mean urinary TCS level corresponding to low, medium, or high exposure was 86.7%. Intraclass correlation coefficients indicated high reproducibility within a week-day (0.77) and week-end day (0.79) and moderate reproducibility across the study period (0.50). CONCLUSIONS: This study provided the first data on temporal variability of urinary TCS concentrations and predictors of exposure in Canadian pregnant women. These results can inform exposure assessments in pregnant women and justify collection of single spot urine samples in epidemiologic studies, especially for women with higher exposures. Crown
Authors: Pahriya Ashrap; Deborah J Watkins; Antonia M Calafat; Xiaoyun Ye; Zaira Rosario; Phil Brown; Carmen M Vélez-Vega; Akram Alshawabkeh; José F Cordero; John D Meeker Journal: Environ Int Date: 2018-10-11 Impact factor: 9.621
Authors: Shaina L Stacy; Melissa Eliot; Taylor Etzel; George Papandonatos; Antonia M Calafat; Aimin Chen; Russ Hauser; Bruce P Lanphear; Sheela Sathyanarayana; Xiaoyun Ye; Kimberly Yolton; Joseph M Braun Journal: Environ Sci Technol Date: 2017-05-25 Impact factor: 9.028
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