Literature DB >> 26009008

A miniaturized readout strategy for endogenous histone deacetylase activity.

Jan Oliver Jost1, Alfred Hanswillemenke, Dirk Schwarzer.   

Abstract

Histone deacetylases are important drug targets, which are difficult to characterize due to their poor accessibility. We have developed a miniaturized assay for the multi-site readout of deacetylase activity and profiled the substrate selectivity of HDACs for acetylation sites on histone H4 and tumor suppressor protein p53.

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Year:  2015        PMID： 26009008     DOI： 10.1039/c5mb00326a

Source DB:  PubMed          Journal:  Mol Biosyst        ISSN： 1742-2051


  2 in total

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Authors:  Caroline E Weller; Champak Chatterjee
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2.  Lysine acetylome profiling uncovers novel histone deacetylase substrate proteins in Arabidopsis.

Authors:  Markus Hartl; Magdalena Füßl; Paul J Boersema; Jan-Oliver Jost; Katharina Kramer; Ahmet Bakirbas; Julia Sindlinger; Magdalena Plöchinger; Dario Leister; Glen Uhrig; Greg Bg Moorhead; Jürgen Cox; Michael E Salvucci; Dirk Schwarzer; Matthias Mann; Iris Finkemeier
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