| Literature DB >> 26006156 |
Fengming Zou1,2, Hongjian Zhou3,4, Tran Van Tan3, Jeonghyo Kim3, Kwangnak Koh5, Jaebeom Lee3.
Abstract
A novel dual-mode immunoassay based on surface-enhanced Raman scattering (SERS) and fluorescence was designed using graphene quantum dot (GQD) labels to detect a tuberculosis (TB) antigen, CFP-10, via a newly developed sensing platform of linearly aligned magnetoplasmonic (MagPlas) nanoparticles (NPs). The GQDs were excellent bilabeling materials for simultaneous Raman scattering and photoluminescence (PL). The one-dimensional (1D) alignment of MagPlas NPs simplified the immunoassay process and enabled fast, enhanced signal transduction. With a sandwich-type immunoassay using dual-mode nanoprobes, both SERS signals and fluorescence images were recognized in a highly sensitive and selective manner with a detection limit of 0.0511 pg mL(-1).Entities:
Keywords: biosensor; dual-mode immunoassay; fluorescence; graphene quantum dots; surface-enhanced Raman scattering; tuberculosis
Mesh:
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Year: 2015 PMID: 26006156 DOI: 10.1021/acsami.5b02523
Source DB: PubMed Journal: ACS Appl Mater Interfaces ISSN: 1944-8244 Impact factor: 9.229