| Literature DB >> 26006087 |
Laura Engelke1, Gerhard Winter1, Sarah Hook2, Julia Engert3.
Abstract
Technologies and strategies for cutaneous vaccination have been evolving significantly during the past decades. Today, there is evidence for increased efficacy of cutaneously delivered vaccines allowing for dose reduction and providing a minimally invasive alternative to traditional vaccination. Considerable progress has been made within the field of well-established cutaneous vaccination strategies: Jet and powder injection technologies, microneedles, microporation technologies, electroporation, sonoporation, and also transdermal and transfollicular vaccine delivery. Due to recent advances, the use of cutaneous vaccination can be expanded from prophylactic vaccination for infectious diseases into therapeutic vaccination for both infectious and non-infectious chronic conditions. This review will provide an insight into immunological processes occurring in the skin and introduce the key innovations of cutaneous vaccination technologies.Entities:
Keywords: DNA vaccination; Dermal dendritic cell; Langerhans cell; Skin microporation; Transcutaneous vaccination; Vaccine adjuvant
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Year: 2015 PMID： 26006087 DOI： 10.1016/j.vaccine.2015.05.012
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641