Literature DB >> 26006012

Drug-target interactions: Stay tuned.

Robert A Copeland1.   

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Year:  2015        PMID： 26006012     DOI： 10.1038/nchembio.1831

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  8 in total

Review 1.  Biochemical mechanisms of drug action: what does it take for success?

Authors:  David C Swinney
Journal:  Nat Rev Drug Discov       Date:  2004-09       Impact factor: 84.694

Review 2.  Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action.

Authors:  Georges Vauquelin; Steven J Charlton
Journal:  Br J Pharmacol       Date:  2010-10       Impact factor: 8.739

3.  Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists.

Authors:  Robert A Copeland
Journal:  Methods Biochem Anal       Date:  2005

Review 4.  Drug-target residence time and its implications for lead optimization.

Authors:  Robert A Copeland; David L Pompliano; Thomas D Meek
Journal:  Nat Rev Drug Discov       Date:  2006-08-04       Impact factor: 84.694

Review 5.  The importance of drug-target residence time.

Authors:  Rumin Zhang; Frederick Monsma
Journal:  Curr Opin Drug Discov Devel       Date:  2009-07

Review 6.  Residence time of receptor-ligand complexes and its effect on biological function.

Authors:  Peter J Tummino; Robert A Copeland
Journal:  Biochemistry       Date:  2008-04-16       Impact factor: 3.162

Review 7.  The behavior and significance of slow-binding enzyme inhibitors.

Authors:  J F Morrison; C T Walsh
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1988

Review 8.  Drug-target residence time: critical information for lead optimization.

Authors:  Hao Lu; Peter J Tonge
Journal:  Curr Opin Chem Biol       Date:  2010-07-19       Impact factor: 8.822
  8 in total
  3 in total

Review 1.  Protein-ligand (un)binding kinetics as a new paradigm for drug discovery at the crossroad between experiments and modelling.

Authors:  M Bernetti; A Cavalli; L Mollica
Journal:  Medchemcomm       Date:  2017-01-30       Impact factor: 3.597

2.  Endless Resistance. Endless Antibiotics?

Authors:  Jed F Fisher; Shahriar Mobashery
Journal:  Medchemcomm       Date:  2015-11-03       Impact factor: 3.597

3.  A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy.

Authors:  Fereidoon Daryaee; Zhuo Zhang; Kayla R Gogarty; Yong Li; Jonathan Merino; Stewart L Fisher; Peter J Tonge
Journal:  Chem Sci       Date:  2017-03-14       Impact factor: 9.825
  3 in total

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